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Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis
Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis
IntroductionEstradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer’s disease and c...
Human stem cell transplantation models of Alzheimer’s disease
Human stem cell transplantation models of Alzheimer’s disease
Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration wi...
tRNS boosts visual perceptual learning in participants with bilateral macular degeneration
tRNS boosts visual perceptual learning in participants with bilateral macular degeneration
Perceptual learning (PL) has shown promise in enhancing residual visual functions in patients with age-related macular deg...
Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years
Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years
IntroductionPersonality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and ...
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study
BackgroundImmunity and neuroinflammation play crucial roles in the pathogenesis of Parkinson’s disease (PD). Nonetheless, ...
Associative Role of HLA-DRB1 as a Protective Factor for Susceptibility and Progression of Parkinson's Disease: A Chinese Cross-Sectional and Longitudinal Study
Associative Role of HLA-DRB1 as a Protective Factor for Susceptibility and Progression of Parkinson's Disease: A Chinese Cross-Sectional and Longitudinal Study
Background: Previous genome-wide association studies investigating the relationship between the HLA-DRB1 and the risk of P...
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats
IntroductionAging is often linked to oxidative stress, where the body experiences increased damage from free radicals. Pla...
Cognitive performance in aged rats is associated with differences in distinctive neuronal populations in the ventral tegmental area and altered synaptic plasticity in the hippocampus
Cognitive performance in aged rats is associated with differences in distinctive neuronal populations in the ventral tegmental area and altered synaptic plasticity in the hippocampus
IntroductionDeterioration of cognitive functions is commonly associated with aging, although there is wide variation in th...
Comparative analysis of multimodal biomarkers for amyloid-beta positivity detection in Alzheimer's disease cohorts
Comparative analysis of multimodal biomarkers for amyloid-beta positivity detection in Alzheimer's disease cohorts
IntroductionEfforts to develop cost-effective approaches for detecting amyloid pathology in Alzheimer's disease (AD) h...
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice
IntroductionAlzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β...
Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?
Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the ...
Dual-task turn velocity – a novel digital biomarker for mild cognitive impairment and dementia
Dual-task turn velocity – a novel digital biomarker for mild cognitive impairment and dementia
BackgroundDisorders associated with cognitive impairment impose a significant burden on both families and society. Previou...
Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors
Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors
IntroductionDeveloping effective treatment for Alzheimer’s disease (AD) remains a challenge. This can be partially attribu...
Sensorineural hearing loss and cognitive impairment: three hypotheses
Sensorineural hearing loss and cognitive impairment: three hypotheses
Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and...
Improve the diagnosis of idiopathic normal pressure hydrocephalus by combining abnormal cortical thickness and ventricular morphometry
Improve the diagnosis of idiopathic normal pressure hydrocephalus by combining abnormal cortical thickness and ventricular morphometry
BackgroundThe primary imaging markers for idiopathic Normal Pressure Hydrocephalus (iNPH) emphasize morphological measurem...
miR-3940-5p reduces amyloid β production via selectively targeting PSEN1
miR-3940-5p reduces amyloid β production via selectively targeting PSEN1
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ...
Impact of olfactory function on the trajectory of cognition, motor function, and quality of life in Parkinson’s disease
Impact of olfactory function on the trajectory of cognition, motor function, and quality of life in Parkinson’s disease
BackgroundOlfactory dysfunction in Parkinson’s disease (PD) is associated with more severe phenotypes, but trajectories of...
Short term effects of contralateral tendon vibration on motor unit discharge rate variability and force steadiness in people with Parkinson’s disease
Short term effects of contralateral tendon vibration on motor unit discharge rate variability and force steadiness in people with Parkinson’s disease
BackgroundVibration of one limb affects motor performance of the contralateral limb, and this may have clinical implicatio...
Non-invasive neuromodulation in reducing the risk of falls and fear of falling in community-dwelling older adults: systematic review
Non-invasive neuromodulation in reducing the risk of falls and fear of falling in community-dwelling older adults: systematic review
IntroductionNeuromodulation is a non-invasive technique that allows for the modulation of cortical excitability and can pr...
Physiotherapy case reports on three people with progressive supranuclear palsy
Physiotherapy case reports on three people with progressive supranuclear palsy
IntroductionProgressive supranuclear palsy (PSP) is a neurodegenerative brain disease that affects patient’s functionality...
Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects
We examined the relationship between hippocampal subfield volumes and cognitive decline over a 4-year period in a healthy ...
Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging
Proteomic signature profiling in the cortex of dairy cattle unravels the physiology of brain aging
IntroductionAging is a physiological process occurring in all living organisms. It is characterized by a progressive deter...
A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer’s disease mouse models through attenuating mitochondrial function
A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer’s disease mouse models through attenuating mitochondrial function
IntroductionAlzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by extracellular senile...
Causal associations between common musculoskeletal disorders and dementia: a Mendelian randomization study
Causal associations between common musculoskeletal disorders and dementia: a Mendelian randomization study
IntroductionDementia and musculoskeletal disorders (MSDs) are major public health problems. We aimed to investigate the ge...
Altered dynamic functional network connectivity in drug-naïve Parkinson’s disease patients with excessive daytime sleepiness
Altered dynamic functional network connectivity in drug-naïve Parkinson’s disease patients with excessive daytime sleepiness
BackgroundExcessive daytime sleepiness (EDS) is a frequent nonmotor symptoms of Parkinson’s disease (PD), which seriously ...
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol
IntroductionPostoperative delirium (POD) is an acute, transient brain disorder associated with decreased postoperative qua...
Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
BackgroundNeuroimaging studies have demonstrated alterations in hippocampal volume and hippocampal subfields among individ...
Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults
Association of plasma amyloid-β oligomerization with theta/beta ratio in older adults
BackgroundOligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer’s disease (AD) diagnosis. Electroencephalograp...
Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease
Different associated factors of subjective cognitive complaints in patients with early and advanced Parkinson's disease
Subjective cognitive complaints (SCCs), defined as cognitive decline reported by subjects or their informants, are common ...
Association between gene expression and altered resting-state functional networks in type 2 diabetes
Association between gene expression and altered resting-state functional networks in type 2 diabetes
BackgroundType 2 diabetes (T2DM) is a polygenic metabolic disorder that accelerates brain aging and harms cognitive functi...
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