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The impact of aerobic exercise dose based on ACSM recommendations on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
The impact of aerobic exercise dose based on ACSM recommendations on patients with Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials
BackgroundTo explore the effects of different dose of aerobic exercise on motor function, balance, mobility, and quality o...
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
MRI radiomics combined with machine learning for diagnosing mild cognitive impairment: a focus on the cerebellar gray and white matter
ObjectiveMild Cognitive Impairment (MCI) is a recognized precursor to Alzheimer’s Disease (AD), presenting a significant r...
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
Disparities in structural brain imaging in older adults from rural communities in Southern Nevada
IntroductionIdentifying the associations between rural-living or neighborhood disadvantage and neurobiology may clarify ru...
Cognitive prehabilitation for older adults undergoing elective surgery: a systematic review and narrative synthesis
Cognitive prehabilitation for older adults undergoing elective surgery: a systematic review and narrative synthesis
BackgroundPerioperative cognitive maintenance and protection in older adults is an important patient safety imperative. In...
Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis
Association of trimethylamine oxide and its precursors with cognitive impairment: a systematic review and meta-analysis
ObjectivesThe role of trimethylamine oxide (TMAO) in patients with cognitive impairment remains controversial. This study ...
A bibliometric analysis of cerebral small vessel disease
A bibliometric analysis of cerebral small vessel disease
BackgroundCerebral small vessel disease (CSVD) is a significant contributor to both stroke and dementia. While numerous st...
A review of proposed mechanisms for neurodegenerative disease
A review of proposed mechanisms for neurodegenerative disease
Neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS) affect millions and ...
Prevalence and risk factors of subjective cognitive decline in older adults in Baotou, China: a cross-sectional study
Prevalence and risk factors of subjective cognitive decline in older adults in Baotou, China: a cross-sectional study
ObjectivesSubjective cognitive decline (SCD) as a stage between healthy cognition and early neurocognitive disorders, has ...
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function
ObjectiveThis study investigates the associations and mediating pathways between grip strength, cognitive function, and de...
Implicit memory reduced selectively for negative words with aging
Implicit memory reduced selectively for negative words with aging
BackgroundDisproportionally better memory for positive versus negative information (mnemonic positivity effect, MPE) in ol...
Neural effects of multisensory dance training in Parkinson’s disease: evidence from a longitudinal neuroimaging single case study
Neural effects of multisensory dance training in Parkinson’s disease: evidence from a longitudinal neuroimaging single case study
Dance is associated with beneficial outcomes in motor and non-motor domains in Parkinson’s disease (PD) and regular partic...
Machine learning models for diagnosing Alzheimer’s disease using brain cortical complexity
Machine learning models for diagnosing Alzheimer’s disease using brain cortical complexity
ObjectiveThis study aimed to develop and validate machine learning models (MLMs) to diagnose Alzheimer’s disease (AD) usin...
Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, significantly prejudicing the heal...
Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China
Sources of perceived social support and cognitive function among older adults: a longitudinal study in rural China
BackgroundStudies have shown the positive impact of perceived social support on cognitive function among older adults in r...
Identification of key proteins in early-onset Alzheimer’s disease based on WGCNA
Identification of key proteins in early-onset Alzheimer’s disease based on WGCNA
IntroductionEarly-onset Alzheimer’s disease (EOAD) is sporadic, highly heterogeneous, and its underlying pathogenic mechan...
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
BackgroundFreezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson’s...
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate
BackgroundBoth frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. Howe...
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease
ObjectivesNeuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder lacking reliable neuroimagin...
Editorial: Model organisms in neuroinflammation and neuropathy: Drosophila melanogaster
neuroinflammation contributes to the pathogenesis of neurological disorders including Alzheimer's disease, Parkins...
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
IntroductionWith age, sensory, cognitive, and motor abilities decline, and the risk for neurodegenerative disorders increa...
“When she goes out, she feels better:” co-designing a Green Activity Program with Hispanic/Latino people living with memory challenges and care partners
“When she goes out, she feels better:” co-designing a Green Activity Program with Hispanic/Latino people living with memory challenges and care partners
PurposeUtilizing a participatory approach, we sought to co-design a 12-week Green Activity Program (GAP) with Hispanic/Lat...
Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study
Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study
BackgroundIn recent years, an increasing number of studies have examined the potential efficacy of cognitive training proc...
In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer’s disease
In-vivo neuronal dysfunction by Aβ and tau overlaps with brain-wide inflammatory mechanisms in Alzheimer’s disease
The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we iden...
Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis
Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis
BackgroundPatients with carotid atherosclerotic stenosis (CAS) often have varying degrees of cognitive decline. However, t...
Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease
Golexanolone reduces glial activation in the striatum and improves non-motor and some motor alterations in a rat model of Parkinson's disease
BackgroundParkinson's disease (PD) affects more than 6 million people worldwide. Along with motor impairments, patien...
Exploring causal correlations of inflammatory biomarkers in idiopathic normal-pressure hydrocephalus: insights from bidirectional Mendelian randomization analysis
Exploring causal correlations of inflammatory biomarkers in idiopathic normal-pressure hydrocephalus: insights from bidirectional Mendelian randomization analysis
Background and objectiveNeuroinflammatory processes have been identified as playing a crucial role in the pathophysiology ...
Impact of white matter hyperintensity volumes estimated by automated methods using deep learning on stroke outcomes in small vessel occlusion stroke
Impact of white matter hyperintensity volumes estimated by automated methods using deep learning on stroke outcomes in small vessel occlusion stroke
IntroductionAlthough white matter hyperintensity (WMH) shares similar vascular risk and pathology with small vessel occlus...
Changes in hippocampal volume, synaptic plasticity and amylin sensitivity in an animal model of type 2 diabetes are associated with increased vulnerability to amyloid-beta in advancing age
Changes in hippocampal volume, synaptic plasticity and amylin sensitivity in an animal model of type 2 diabetes are associated with increased vulnerability to amyloid-beta in advancing age
Type-2 diabetes (T2D) is a metabolic disorder that is considered a risk factor for Alzheimer's disease (AD). Cognitiv...
Enhancing predictive validity of motoric cognitive risk syndrome for incident dementia and all-cause mortality with handgrip strength: insights from a prospective cohort study
Enhancing predictive validity of motoric cognitive risk syndrome for incident dementia and all-cause mortality with handgrip strength: insights from a prospective cohort study
BackgroundThis study aimed to assess whether integrating handgrip strength (HGS) into the concept of motoric cognitive ris...
Aberrant decision-making as a risk factor for falls in aging
Aberrant decision-making as a risk factor for falls in aging
Neuromotor impairments resulting from natural aging and aging-related diseases are often accompanied by a heightened preva...
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