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Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca2+ release
Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca2+ release
Cholestatic liver disease is characterized by highly accumulated bile acids and cholangiocyte proliferation, resulting in ...
Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation
Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation
Briancon-Scheid F, Lobstein-Guth A, Anton R. HPLC separation and quantitative determination of biflavones in leaves from G...
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment
Ubiquitin-specific protease 14 (USP14) is a crucial modulator of proteasomal function and cellular proteostasis, which pla...
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway
Rheumatoid arthritis with depressive symptoms is frequently encountered in clinic. In this study, we investigated the mole...
Programmed sequential nanostructural conversion at nano-bio interface for synergistic cancer phototheranostics
Programmed sequential nanostructural conversion at nano-bio interface for synergistic cancer phototheranostics
Prodrugs usually convert into active compounds within cells via endogenous or external stimuli to improve the diagnostic a...
circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis
circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis
Increasing evidence shows that microRNAs (miRNAs) are functionally associated with cardiac remodeling. Functionally, some ...
Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects
Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects
Inhibition of autophagy has been considered as a promising strategy for tumor therapy, discovery of small-molecule autopha...
Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability
Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability
Hyperuricemia and gout are increasingly prevalent among global health concerns, necessitating the development of more effe...
Retraction Note: Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma
Authors and AffiliationsDepartment of Otolaryngology, Qingdao Municipal Hospital, Qingdao, 266011, ChinaMing-jie Pang, Zhu...
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
The original online version of this article was revised: The authors would like to apologize for the errors in the previou...
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors
G protein-coupled receptors (GPCRs) are critical drug targets involved in numerous physiological processes, yet many of th...
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses
Astrocytes are known to modulate synaptogenesis or neuronal activities, thus participating in mental functions. It has bee...
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells
As a pathological feature of diabetic kidney disease (DKD), dysregulated glomerular filtration barrier function could lead...
A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia
A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia
Despite the vital role of astrocytes in preserving blood-brain barrier (BBB) integrity, their therapeutic potential as tar...
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons
Itch causes a strong urge to scratch and induces negative emotions, such as aversion and anxiety. Antihistamine medication...
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy
Colchicine reduces neointima formation and VSMC phenotype transition by modulating SRF-MYOCD activation and autophagy
Vascular smooth muscle cell (VSMC) phenotype transformation significantly contributes to vascular intimal hyperplasia. How...
Targeted degradation of membrane and extracellular proteins with LYTACs
Targeted degradation of membrane and extracellular proteins with LYTACs
Targeted protein degradation technology has gained substantial momentum over the past two decades as a revolutionary strat...
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration
Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration
Esculetin (ESC) is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute isc...
Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis
Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis
Our previous study shows that activation of pregnane X receptor (PXR) exerts hepatoprotection against lithocholic acid (LC...
Cyclic GMP-AMP synthase recognizes the physical features of DNA
Cyclic GMP-AMP synthase recognizes the physical features of DNA
Cyclic GMP-AMP synthase (cGAS) is a major cytosolic DNA sensor that plays a significant role in innate immunity. Upon bind...
The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca2+ transport in the pathogenesis of diseases
The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca2+ transport in the pathogenesis of diseases
Mitochondria and the endoplasmic reticulum (ER) are vital organelles that influence various cellular physiological and pat...
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis
Doxorubicin (DOX), a common chemotherapeutic agent in cancer therapy, is accompanied by pronounced cardiotoxicity. Ferropt...
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
The pyroptosis of renal tubular epithelial cells leads to tubular loss and inflammation and then promotes renal fibrosis. ...
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder characterized by cognitive impairments. De...
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tu...
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causin...
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Cancer cells largely rely on aerobic glycolysis or the Warburg effect to generate essential biomolecules and energy for th...
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR
Despite the effectiveness of antiretroviral therapy (ART) in prolonging the lifespan of individuals infected with HIV-1, i...
Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1: structures, related diseases, and drug discovery
Liver receptor homolog-1 (LRH-1), a member of the nuclear receptor superfamily, is a ligand-regulated transcription factor...
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers
Frizzled receptors (FZDs) are key contributors intrinsic to the Wnt signaling pathway, activation of FZDs triggering the W...
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