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Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD
Objective:This study aimed to quantitatively compare the efficacy and safety of long-acting β2-agonist (LABA)/long-acting ...
Therapeutic Advances In Respiratory Disease
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Physiological predictors of cardiorespiratory fitness in children and adolescents with cystic fibrosis without ventilatory limitation
Objectives:[1] To investigate the cardiorespiratory fitness (CRF) levels in children and adolescents with cystic fibrosis ...
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Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke
Introduction/Rationale:In chronic obstructive pulmonary disease (COPD), defective macrophage phagocytic clearance of cells...
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Validation of a visual analog scale for assessing cough severity in patients with chronic cough
Introduction:Patients with chronic cough experience considerable burden. The cough severity visual analog scale (VAS) reco...
Therapeutic Advances In Respiratory Disease
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The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study
Aim:The aim of this study was to investigate the predictive role of lymphocyte subsets and other laboratory measurements i...
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Anti-interleukin 5 therapies failure criteria in severe asthma: a Delphi-consensus study
Background:Current practices for assessing response to anti-interleukin 5/R treatment in severe asthma patients are hetero...
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Severe COVID-19 among patients with asthma and COPD: a report from the Swedish National Airway Register
Background:Patients with obstructive lung diseases may be at risk of hospitalization and/or death due to COVID-19.Aim:To e...
Therapeutic Advances In Respiratory Disease
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A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study
Background:Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (CO...
Therapeutic Advances In Respiratory Disease
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Manifesto on the overuse of SABA in the management of asthma: new approaches and new strategies
The risks of overusing short-acting β2-agonists (SABA), including an increase in asthma-related deaths, are many and well ...
Therapeutic Advances In Respiratory Disease
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Effectiveness of corticosteroids on chest high-resolution computed tomography features of COVID-19 pneumonia
Objective:The aim of our study was to assess the effect of a short-term treatment with low-moderate corticosteroid (CS) do...
Therapeutic Advances In Respiratory Disease
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The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging
Background:Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cys...
Therapeutic Advances In Respiratory Disease
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Gender differences in non-cystic fibrosis bronchiectasis severity and bacterial load: the potential role of hormones
Non cystic-fibrosis bronchiectasis (NCFB) is a complex chronic respiratory disease, characterised by excessive sputum prod...
Therapeutic Advances In Respiratory Disease
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DSP rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study
Background:The antifibrotic drugs nintedanib and pirfenidone are used for the treatment of idiopathic pulmonary fibrosis (...
Therapeutic Advances In Respiratory Disease
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Therapeutic closure of bronchopleural fistulas using ethanol
Bronchopleural fistula (BPF) leading to persistent air leak (PAL), be it a complication of pulmonary resection, radiation,...
Therapeutic Advances In Respiratory Disease
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Monitoring and management of fibrosing interstitial lung diseases: a narrative review for practicing clinicians
Close monitoring of patients with fibrosing interstitial lung diseases (ILDs) is important to enable prompt identification...
Therapeutic Advances In Respiratory Disease
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Improvements in lung function with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler versus dual therapies in patients with COPD: a sub-study of the ETHOS trial
Background:In the phase III, 52-week ETHOS study in patients with moderate to very severe chronic obstructive pulmonary di...
Therapeutic Advances In Respiratory Disease
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PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
Background:Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VIDD). Although the devel...
Therapeutic Advances In Respiratory Disease
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Impact of COVID-19 on social determinants of health for adults with cystic fibrosis
Introduction:Outcomes in cystic fibrosis are influenced by multiple factors, including social determinants of health. Low ...
Therapeutic Advances In Respiratory Disease
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A non-interventional switch study in adult patients with asthma or COPD on clinical effectiveness of salmeterol/fluticasone Easyhaler® in routine clinical practice
Background:Selection of the most appropriate device for a switch from one inhaler to an equivalent product is known to hav...
Therapeutic Advances In Respiratory Disease
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The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease in which most patients die within 3 years of d...
Therapeutic Advances In Respiratory Disease
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LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Aims:Chronic obstructive pulmonary disease (COPD) is a systemic disease. Several long non-coding RNAs (lncRNAs) have been ...
Therapeutic Advances In Respiratory Disease
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Clinical effectiveness of convalescent plasma in hospitalized patients with COVID-19: a systematic review and meta-analysis
Aims:Given the variability of previously reported results, this systematic review aims to determine the clinical effective...
Therapeutic Advances In Respiratory Disease
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An increased risk of lung cancer in combined pulmonary fibrosis and emphysema patients with usual interstitial pneumonia compared with patients with idiopathic pulmonary fibrosis alone: a systematic review and meta-analysis
Background:Lung cancer is an important complication of combined pulmonary fibrosis and emphysema (CPFE). Whether the risk ...
Therapeutic Advances In Respiratory Disease
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Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis
Background and aims:Post-tuberculosis bronchial stenosis (PTBS) is one of the most common complications of tracheobronchia...
Therapeutic Advances In Respiratory Disease
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Virtual bronchoscopic navigation versus non-virtual bronchoscopic navigation assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: a systematic review and meta-analysis
Background:Image-guided bronchoscopy techniques such as virtual bronchoscopic navigation (VBN) has emerged as a means of a...
Therapeutic Advances In Respiratory Disease
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High flow nasal cannula oxygenation in COVID-19 related acute respiratory distress syndrome: a safe way to avoid endotracheal intubation?
Backgrounds:High flow nasal cannula (HFNC) is an alternative therapy for acute respiratory distress syndrome (ARDS) due to...
Therapeutic Advances In Respiratory Disease
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Pyogenic lung abscess in an infectious disease unit: a 20-year retrospective study
Background:Pyogenic lung abscesses are rare and poorly described infections. This study aimed to describe their prognostic...
Therapeutic Advances In Respiratory Disease
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Does pre-existent physical inactivity have a role in the severity of COVID-19?
Background and Aims:Physical inactivity is considered an important lifestyle factor for overweight and cardiovascular dise...
Therapeutic Advances In Respiratory Disease
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