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Classifying the molecular functions of transcription factors beyond activation and repression [Outlook]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Circadian de(regulation) in physiology: implications for disease and treatment [Reviews]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformations [Research Communications]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Notch induces transcription by stimulating release of paused RNA polymerase II [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Chronic interferon-stimulated gene transcription promotes oncogene-induced breast cancer [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Proteomic insights into circadian transcription regulation: novel E-box interactors revealed by proximity labeling [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
DNA-directed termination of mammalian RNA polymerase II [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Corrigendum: Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity [Errata]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Evidence for dual roles of histone H3 lysine 4 in antagonizing Polycomb group function and promoting target gene expression [Research Papers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Reviewers, Volume 38 (2024) [Reviewers]
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemi...
Cultivation of primary cells derived from three organs of a striped dolphin (Stenella coeruleoalba) using a simple culture method
Cultivation of primary cells derived from three organs of a striped dolphin (Stenella coeruleoalba) using a simple culture method
Cetacean-cultured cells are a promising tool for life science research. Most cells used in cetacean research are derived f...
Inhibition of FOXO3 ameliorates ropivacaine-induced nerve cell damage through the miR-126-5p/TRAF6 axis
Inhibition of FOXO3 ameliorates ropivacaine-induced nerve cell damage through the miR-126-5p/TRAF6 axis
Local anesthetics, such as ropivacaine (Ropi), are toxic to nerve cells. We aimed to explore the role of forkhead box O3 (...
Arf1 promotes porcine intestinal epithelial cell proliferation via the mTORC1 signaling pathway
Arf1 promotes porcine intestinal epithelial cell proliferation via the mTORC1 signaling pathway
The promotion of gut health, a pervasive problem in modern animal husbandry, positively affects organismal health, product...
Ginsenoside Re promotes proliferation of murine bone marrow mesenchymal stem cells in vitro through estrogen-like action
Ginsenoside Re promotes proliferation of murine bone marrow mesenchymal stem cells in vitro through estrogen-like action
Ginsenoside Re (GS-Re) is a major saponin monomer found in Panax ginseng Meyer. It has been shown to exhibit a wide range ...
SFRP1 reduces neutrophil infiltration and inhibits the Wnt/β-catenin pathway to alleviate oral submucous fibrosis
SFRP1 reduces neutrophil infiltration and inhibits the Wnt/β-catenin pathway to alleviate oral submucous fibrosis
Oral submucous fibrosis (OSF) is a precancerous condition characterized by oral mucosal atrophy with fibrosis of the submu...
Protection from oxygen–glucose deprivation by neurosteroid treatment in primary neurons and oligodendrocytes
Protection from oxygen–glucose deprivation by neurosteroid treatment in primary neurons and oligodendrocytes
Preterm birth results in an increased risk of neonatal brain injury and neurobehavioural disorders. Despite the seriousnes...
Role of NF-κB signaling pathway in H2O2-induced oxidative stress of hiPSCs
Role of NF-κB signaling pathway in H2O2-induced oxidative stress of hiPSCs
The balance between oxidation and antioxidation is crucial for the development of embryo. It is harmful to the early embry...
Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells
Effect of transcription factor MEOX on insulin gene expression in glucagon-like peptide 1-secreting cells
Currently, the supply of beta cells for islet transplantation in the treatment of type 1 diabetes is limited. Enteroendocr...
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy
Adipose-derived cells surpass muscle-derived cells in primary cell isolation efficacy
Anna T, Agnieszka BZ (2021) Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy....
Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation
Pre-vascularized porous gelatin-coated β-tricalcium phosphate scaffolds for bone regeneration: an in vivo and in vitro investigation
Vascularization is vital in bone tissue engineering, supporting development, remodeling, and regeneration. Lack of vascula...
Pharmacoproteogenomic approach identifies on-target kinase inhibitors for cancer drug repositioning
Pharmacoproteogenomic approach identifies on-target kinase inhibitors for cancer drug repositioning
Drug repositioning of approved drugs offers advantages over de novo drug development for a rare type of cancer. To efficie...
Pluripotent cells derived from 50% epiboly zebrafish embryos
Pluripotent cells derived from 50% epiboly zebrafish embryos
Choorapoikayil S, Overvoorde J, Den HJ (2013) Deriving cell lines from zebrafish embryos and tumors. Zebrafish 10:316–325A...
Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells
Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells
This study aimed to explore the potential of using mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos) pre-treated wit...
Optimization of embryonic stage for aggregation to generate chimeric pigs using gene-edited blastomeres
Optimization of embryonic stage for aggregation to generate chimeric pigs using gene-edited blastomeres
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates o...
IL-27 attenuated macrophage injury and inflammation induced by Mycobacterium tuberculosis by activating autophagy
IL-27 attenuated macrophage injury and inflammation induced by Mycobacterium tuberculosis by activating autophagy
Interleukin-27 (IL-27) is a cytokine that is reported to be highly expressed in the peripheral blood of patients with pulm...
Use of modified human hemangioma tissue cultures and human umbilical vein endothelial cell cultures to gain mechanistic insights into imiquimod treatment for infantile hemangioma
Use of modified human hemangioma tissue cultures and human umbilical vein endothelial cell cultures to gain mechanistic insights into imiquimod treatment for infantile hemangioma
Infantile hemangiomas (IH) are a common entity encountered by dermatologists, otolaryngologists, and other surgeons. Oral ...
Zebrafish: unraveling genetic complexity through duplicated genes
Zebrafish: unraveling genetic complexity through duplicated genes
The zebrafish is an invaluable model organism for genetic, developmental, and disease research. Although its high conserva...
Effects of two chd2-knockout strains on the morphology and behavior in zebrafish
Effects of two chd2-knockout strains on the morphology and behavior in zebrafish
The chromodomain helicase DNA binding domain 2 (CHD2) gene is an ATPase and a member of the SNF2-like family of helicase-r...
Molecular evolution and genetic diversity of defective chorion 1 in Anastrepha fraterculus and Anastrepha obliqua (Diptera, Tephritidae)
Molecular evolution and genetic diversity of defective chorion 1 in Anastrepha fraterculus and Anastrepha obliqua (Diptera, Tephritidae)
The family Tephritidae comprises numerous fruit fly species, some of which are economically significant, such as several i...
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection
According to official statistics, cancer remains the main reason of death and over 50% of patients with cancer receive rad...
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