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A developmental atlas of male terminalia across twelve species of Drosophila
A developmental atlas of male terminalia across twelve species of Drosophila
How complex morphologies evolve is one of the central questions in evolutionary biology. Observing the morphogenetic event...
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins
Sequence and structural insights of monoleucine-based sorting motifs contained within the cytoplasmic domains of basolateral proteins
Delivery to the correct membrane domain in polarized epithelial cells is a critical regulatory mechanism for transmembrane...
The role of mitochondria in eosinophil function: implications for severe asthma pathogenesis
The role of mitochondria in eosinophil function: implications for severe asthma pathogenesis
Mitochondria are key metabolic hubs involved in cellular energy production and biosynthesis. ATP is generated primarily by...
Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells
Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells
Signal regulatory protein-α (SIRPα, SHPS-1, CD172a) expressed on myeloid cells transmits inhibitory signals when it engage...
Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist
Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist
The extracellular matrix (ECM) is a highly complex structure through which biochemical and mechanical signals are transmit...
Editorial: Molecular architecture and dynamics of meiotic chromosomes
Editorial: Molecular architecture and dynamics of meiotic chromosomes
Meiosis is a special type of cell division that allows the generation of haploid gametes and is a key process for sexual r...
Cell type-specific regulation of CFTR trafficking—on the verge of progress
Cell type-specific regulation of CFTR trafficking—on the verge of progress
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts wit...
Editorial: Proteins and protein-complexes underlying mitochondrial structure-function and metabolism: implications in diseases
Editorial: Proteins and protein-complexes underlying mitochondrial structure-function and metabolism: implications in diseases
The authors found a significant decrease in CHRM1 proteins (>50% decrease compared to age-matched non-demented individu...
Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research
Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resista...
Cell-cell interaction in the pathogenesis of inherited retinal diseases
Cell-cell interaction in the pathogenesis of inherited retinal diseases
The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of c...
High-resolution 3D ultrastructural analysis of developing mouse neocortex reveals long slender processes of endothelial cells that enter neural cells
High-resolution 3D ultrastructural analysis of developing mouse neocortex reveals long slender processes of endothelial cells that enter neural cells
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known ...
Research advances of polycomb group proteins in regulating mammalian development
Research advances of polycomb group proteins in regulating mammalian development
Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved throughout evolution. In mammal...
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression
DNA methylation (DNAme) has long been recognized as a host defense mechanism, both in the restriction modification systems...
Primary sarcopenia is associated with elevated spontaneous NET formation
Primary sarcopenia is associated with elevated spontaneous NET formation
Introduction: Sarcopenia is a frequent complication of liver cirrhosis, but it can also occur independently as a result of...
Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer
Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer
Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled r...
Developmental outcome of electroencephalographic findings in SYNGAP1 encephalopathy
Developmental outcome of electroencephalographic findings in SYNGAP1 encephalopathy
SYNGAP1 haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies ac...
Editorial: Coordinated regulation of the balance between stem cell self-renewal and differentiation
Editorial: Coordinated regulation of the balance between stem cell self-renewal and differentiation
The balance between stem cell self-renewal and differentiation is a complex mechanism regulated by different factors and s...
Interaction between immuno-stem dual lineages in jaw bone formation and injury repair
Interaction between immuno-stem dual lineages in jaw bone formation and injury repair
The jawbone, a unique structure in the human body, undergoes faster remodeling than other bones due to the presence of ste...
Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine
Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine
Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nuc...
MYC: there is more to it than cancer
MYC: there is more to it than cancer
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targe...
New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy
New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy
Ferroptosis, characterized by iron accumulation and lipid peroxidation, is a form of iron-driven cell death. Mitophagy is ...
An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations
An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis....
ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, continues to spread around ...
Signaling plasticity in the integrated stress response
Signaling plasticity in the integrated stress response
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic c...
Editorial: Artificial intelligence applications in chronic ocular diseases
Editorial: Artificial intelligence applications in chronic ocular diseases
Editorial: Artificial Intelligence Applications in Chronic Ocular DiseasesYanwu Xu1,2, Weihua Yang31School of Future Techn...
Gene expression in mice with endothelium-specific telomerase knockout
Gene expression in mice with endothelium-specific telomerase knockout
Endothelial cells (EC), lining the vasculature, serve essential functions fundamental for normal physiology of every organ...
Extracellular molecular signals shaping dendrite architecture during brain development
Extracellular molecular signals shaping dendrite architecture during brain development
Proper growth and branching of dendrites are crucial for adequate central nervous system (CNS) functioning. The neuronal d...
Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review
Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review
Low back pain caused by disc herniation and spinal stenosis imposes an enormous medical burden on society due to its high ...
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
A single Aurora kinase found in non-vertebrate deuterostomes is assumed to represent the ancestor of vertebrate Auroras A/...
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian c...
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