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USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling
Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with ...
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Involvement of Kindlin-1 in cutaneous squamous cell carcinoma
Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes ...
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients
Fanconi anemia (FA) is a rare hereditary disease resulting from an inactivating mutation in the FA/BRCA pathway, critical ...
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif ...
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biologic...
Cell competition in primary and metastatic colorectal cancer
Cell competition in primary and metastatic colorectal cancer
Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the e...
Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth
Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth
Bladder cancer is characterized by aberrant activation of the phosphatidylinositol-3-OH kinase (PI3K) signaling, underscor...
Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
Neratinib is a tyrosine kinase inhibitor that is used for the therapy of patients with HER2+ breast tumors. However, despi...
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression
DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression
Pancreatic ductal adenocarcinoma (PDAC) is recognized as the most aggressive and fatal malignancy. A previous study report...
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma
Protein kinase C (PKC) is activated downstream of gain-of-function GNAQ or GNA11 (GNAQ/GNA11) mutations in over 90% of uve...
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma
Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue i...
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling
Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A...
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide a...
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development
Change within the intratumoral microbiome is a common feature in lung and other cancers and may influence inflammation and...
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain
The BCL2 family of proteins controls cell death by modulating the permeabilization of the mitochondrial outer membrane thr...
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development
Our study aimed to elucidate the molecular mechanisms underlying NAC1 (nucleus accumbens associated 1) transcriptional reg...
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC...
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, th...
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display...
Molecular mechanisms in colitis-associated colorectal cancer
Molecular mechanisms in colitis-associated colorectal cancer
Sustained chronic inflammation of the large intestine leads to tissue damage and repair, which is associated with an incre...
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expr...
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Although many studies have compared tumor fibroblasts (T-Fbs) and nontumor fibroblasts (N-Fbs), less is understood about t...
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Triple negative breast cancer (TNBC) is defined as lacking the expressions of estrogen receptor (ER), progesterone recepto...
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcrip...
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently reported to be hyperactivated in he...
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain un...
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD+. However, the role of AIFM2 in the progressio...
Discovery of neddylation E2s inhibitors with therapeutic activity
Discovery of neddylation E2s inhibitors with therapeutic activity
Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (N...
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherei...
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