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Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification
Abstract The rates of melanoma and non-melanoma skin cancer (NMSC) have been increasing over the last twenty years in the ...
Experimental Dermatology
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BRN2 and MITF together impact AXL expression in melanoma
Abstract The inverse relationship between transcription factor MITF and receptor tyrosine kinase AXL has received much att...
Experimental Dermatology
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Long non‐coding RNA LINC00665 promotes melanoma cell growth and migration via regulating the miR‐224‐5p/VMA21 axis
Abstract Melanoma is an aggressive malignant skin tumor endangering the health of patients. Long non-coding RNAs (lncRNAs)...
Experimental Dermatology
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Ultra‐high‐frequency ultrasound and machine learning approaches for the differential diagnosis of melanocytic lesions
Abstract Malignant melanoma (MM) is one of the most dangerous skin cancers. The aim of this study was to present a potenti...
Experimental Dermatology
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Melanoma brain metastases: Biological basis and novel therapeutic strategies
Abstract The development of brain metastases is the deadliest complication of advanced melanoma and has long been associat...
Experimental Dermatology
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Sorafenib induces pigmentation via the regulation of β‐catenin signalling pathway in melanoma cells
Abstract We conducted large-scale screening test on drugs that were already approved for other diseases to find pigmentati...
Experimental Dermatology
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Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape
Abstract Non-cutaneous melanomas most frequently involve the uveal tract and mucosal membranes, including the conjunctiva....
Experimental Dermatology
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Programmed gene expression change in mouse skin after ultraviolet radiation damage
Abstract Ultraviolet (UV) radiation is a major cause of skin damage and carcinogenesis. Here, we systematically analyse th...
Experimental Dermatology
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Roles of cutaneous cell‐cell communication in wound healing outcome: An emphasis on keratinocyte‐fibroblast crosstalk
Abstract Tissue repair is a very complex event and involves a continuously orchestrated sequence of signals and responses ...
Experimental Dermatology
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Mutational landscape in squamous cell carcinoma of the nail unit
Abstract Background Squamous cell carcinoma (SCC) is the most common malignancy of the nail unit. Pathogenetic mechanisms ...
Experimental Dermatology
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The programmed gene expression change in mouse skin after ultraviolet radiation damage
ABSTRACT Ultraviolet (UV) radiation is a major cause of skin damage and carcinogenesis. Here we systematically analyze the...
Experimental Dermatology
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Roles of Cutaneous Cell‐Cell Communication in Wound Healing Outcome: Emphasis on Keratinocyte‐Fibroblast Crosstalk
Abstract Tissue repair is a very complex event and involves a continuously orchestrated sequence of signals and responses ...
Experimental Dermatology
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miR‐24‐3p obstructs the proliferation and migration of HSFs after thermal injury by targeting PPAR‐β and positively regulated by NF‐κB
Abstract Thermal injury repair is a complex process during which the maintenance of the proliferation and migration of hum...
Experimental Dermatology
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Effects of amniotic fluid on human keratinocyte gene expression ‐ Implications for wound healing
Abstract Cutaneous wounds can lead to huge suffering for patients. Early fetal wounds have the capacity to regenerate with...
Experimental Dermatology
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Concomitant Variants in NF1, LZTR1, and GNAZ Genes Probably Contribute to the Aggressiveness of Plexiform Neurofibroma and Warrant Treatment with MEK Inhibitor
Abstract Neurofibromatosis 1 (NF1) is caused by germline mutations in the NF1 gene and manifests as proliferation of vario...
Experimental Dermatology
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Transglutaminase 2 mediates UVB‐induced matrix metalloproteinase‐1 expression by inhibiting nuclear p65 degradation in dermal fibroblasts
Abstract Matrix metalloproteinases (MMPs) play a key role in tissue remodeling by cleaving extracellular matrix (ECM) comp...
Experimental Dermatology
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Small plaque psoriasis re‐visited: A type of psoriasis mediated by a type‐I interferon pathway
Abstract TNFα-inhibitor-induced psoriasis is mediated by the type-I interferon pathway, of which IFNα, LL37 an...
Experimental Dermatology
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Tranexamic acid inhibits melanogenesis partially via stimulation of TGF‐β1 expression in human epidermal keratinocytes
Abstract Background Oral tranexamic acid (TA) has been an effective treatment for melasma with unclear mechanism. Objectiv...
Experimental Dermatology
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Novel PTCH1 and concurrent TP53 mutations in four patients with numerous non‐syndromic basal cell carcinomas: The paradigm of oncogenic synergy
ABSTRACT There has been a significant increase in basal cell carcinoma (BCC) incidence, the most common cancer in humans, ...
Experimental Dermatology
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Evaluation of human acellular amniotic membrane for promoting anterior auricle reconstruction
Corresponding Author Department of Dermatology, Sichuan University West China H...
Experimental Dermatology
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Topical κ‐Opioid Receptor Agonist Asimadoline Improves Dermatitis in a Canine Model of Atopic Dermatitis
Abstract This prospective, 4-week, placebo-controlled, cross-over study aimed to investigate the efficacy of 1% topical ...
Experimental Dermatology
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Impact of the chronic wound microenvironment and marine omega‐3 fatty acids on skin cell regeneration processes
ABSTRACT Marine long chain omega-3 polyunsaturated fatty acids (ω3 FA) are involved in numerous cell responses and t...
Experimental Dermatology
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Studying the in vivo application of a liquid dermal scaffold in promoting wound healing in a mouse model
Abstract Lack of matrix deposition is one of the main factors that complicates the healing process of wounds. The aim of t...
Experimental Dermatology
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Ketoconazole beyond antifungal activity: bioinformatics‐based hypothesis on lipid metabolism in dandruff and seborrheic dermatitis
Corresponding Author Center for Natural Sciences and Humanities, Federal Univer...
Experimental Dermatology
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An integrative multi‐omic analysis reveals a major metabolic rewiring between baby foreskin keratinocytes and adult female abdominal keratinocytes.
Abstract Even though its development starts early in utero, neonatal skin is still immature at birth relative to adult and...
Experimental Dermatology
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Gene expression profiling of laminin α3 blocked keratinocytes reveals an immune‐independent mechanism of blistering
Abstract Laminin-332 pemphigoid is a rare and chronic autoimmune blistering disease which results in subepidermal blisters...
Experimental Dermatology
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Vorinostat, a histone deacetylase inhibitor, as a potential novel treatment for psoriasis
Abstract Background Psoriasis is characterized by aberrant activation of several pro-inflammatory circuits as well as abno...
Experimental Dermatology
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Evidence for a role of extracellular heat shock protein 70 in epidermolysis bullosa acquisita
Abstract Heat shock protein 90 (Hsp90) and Hsp70 are chaperones implicated in different inflammatory disorders, given thei...
Experimental Dermatology
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Two novel mutations of the γ‐secretase genes in Chinese acne inversa (hidradenitis suppurativa)
Corresponding Author McKusick-Zhang Center for Genetic Medicine, State Key Labo...
Experimental Dermatology
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MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity
Abstract MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and power...
Experimental Dermatology
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