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Repeated surgical resections for management of high-grade glioma and its impact on quality of life
Repeated surgical resections for management of high-grade glioma and its impact on quality of life
High-grade gliomas (HGG) are aggressive cancers, and their recurrence is inevitable, despite advances in treatment options...
Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype
Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype
Recent studies have identified that glioblastoma IDH-wildtype consists of different molecular subgroups with distinct prog...
The role of spine stereotactic radiosurgery for patients with breast cancer metastases
The role of spine stereotactic radiosurgery for patients with breast cancer metastases
Breast cancer that metastasizes to the spine is associated with low quality of life and poor survival. Radiosurgery has an...
Predictive role of intracranial PD-L1 expression in a real-world cohort of NSCLC patients treated with immune checkpoint inhibition following brain metastasis resection
Predictive role of intracranial PD-L1 expression in a real-world cohort of NSCLC patients treated with immune checkpoint inhibition following brain metastasis resection
Emerging evidence suggests that treatment of NSCLC brain metastases with immune checkpoint inhibitors (ICIs) is associated...
Stereotactic radiosurgery for intracranial adenoid cystic carcinoma
Stereotactic radiosurgery for intracranial adenoid cystic carcinoma
Lang K, Adeberg S, Harrabi S et al (2021) Adenoid cystic Carcinoma and Carbon ion only irradiation (ACCO): study protocol ...
Effect of Pneumocystis jirovecii pneumonia prophylaxis on hematologic toxicity in patients receiving chemoradiation for primary brain tumors
Effect of Pneumocystis jirovecii pneumonia prophylaxis on hematologic toxicity in patients receiving chemoradiation for primary brain tumors
Diffuse gliomas are managed with radiation and temozolomide; however, this therapy often results in hematologic toxicities...
The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
Various molecular profiles are needed to classify malignant brain tumors, including gliomas, based on the latest classific...
Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
This study investigated whether Ki-67 labeling index (LI) correlated with clinical outcomes after SRS for atypical meningi...
Imaging as an early biomarker to predict sensitivity to everolimus for progressive NF2-related vestibular schwannoma
Imaging as an early biomarker to predict sensitivity to everolimus for progressive NF2-related vestibular schwannoma
NF2-related schwannomatosis (NF2) is characterized by bilateral vestibular schwannomas (VS) often causing hearing and neur...
The risk and burden of thromboembolic and hemorrhagic events in patients with malignant gliomas receiving bevacizumab
The risk and burden of thromboembolic and hemorrhagic events in patients with malignant gliomas receiving bevacizumab
Bevacizumab has evolved as an integral treatment option for patients with high-grade gliomas. Little is known about clinic...
Leptomeningeal carcinomatosis and brain metastases in gastroesophageal carcinoma: a real-world analysis of clinical and pathologic characteristics and outcomes
Leptomeningeal carcinomatosis and brain metastases in gastroesophageal carcinoma: a real-world analysis of clinical and pathologic characteristics and outcomes
Brain metastasis (BrM) and Leptomeningeal Carcinomatosis (LMC) are uncommon complications in gastroesophageal carcinoma (G...
Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response
Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response
Autopsy-based radio-pathomic maps of glioma pathology have shown substantial promise inidentifying areas of non-enhancing ...
Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
Glioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fing...
Prognostic factors analysis of diffuse midline glioma
Prognostic factors analysis of diffuse midline glioma
This study retrospectively analyzes cases of diffuse midline glioma treated with radiotherapy, with the aim of investigati...
Hypofractionated stereotactic re-irradiation for progressive glioblastoma: twelve years’ experience of a single center
Hypofractionated stereotactic re-irradiation for progressive glioblastoma: twelve years’ experience of a single center
We aimed to evaluate the prognostic factors and the role of stereotactic radiotherapy (SRT) as a re-irradiation technique ...
RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma
RFX2 promotes tumor cell stemness through epigenetic regulation of PAF1 in spinal ependymoma
Spinal ependymoma (SE) is a rare tumor that is most commonly low-grade and tends to recur when complete tumor resection is...
Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study
Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study
Blood–brain barrier (BBB) remains to be the major obstacle to conquer in treating patients with malignant brain tumo...
Ganciclovir as a potential treatment for glioma: a systematic review and meta-analysis
Ganciclovir as a potential treatment for glioma: a systematic review and meta-analysis
Glioma is a challenging malignant tumor with a low survival rate and no effective treatment. Recently, ganciclovir, an ant...
Management strategies for intracranial progression in ALK-positive non-small cell lung cancer: a real-world cohort study
Management strategies for intracranial progression in ALK-positive non-small cell lung cancer: a real-world cohort study
ALK-positive NSCLC patients exhibit a particularly high propensity for the development of brain metastases. Current guidel...
Incidental meningiomas: a current and increasingly common challenge
Incidental meningiomas: a current and increasingly common challenge
Näslund O, Strand PS, Solheim O et al (2023) Incidence, management, and outcome of incidental meningioma: what has happene...
Treatment of very elderly glioblastoma patients ≥ 75 years of age: whom to treat
Treatment of very elderly glioblastoma patients ≥ 75 years of age: whom to treat
The prognosis of patients ≥ 75 years suffering from glioblastoma is poor. Novel therapies are usually re...
Pyruvate kinase M2 (PKM-2) expression and prognostic significance in glioblastoma patients
Pyruvate kinase M2 (PKM-2) expression and prognostic significance in glioblastoma patients
Pyruvate kinase M2 (PKM2) is a key enzyme that catalyzes the irreversible and final step of glycolysis. It is closely asso...
A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM)
A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM)
A multi-site Phase I trial was conducted to determine the safety, maximum tolerated dose, and pharmacokinetics (PK) of Vel...
Development of a “Geo-Tagged” tumor sample registry: intra-operative linkage of sample location to imaging
Development of a “Geo-Tagged” tumor sample registry: intra-operative linkage of sample location to imaging
There is a growing body of literature documenting glioma heterogeneity in terms of radiographic, histologic, molecular, an...
Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis
Liquid biopsy in the setting of leptomeningeal metastases: a systematic review and meta-analysis
The blood-brain barrier can prevent circulating tumor DNA (ctDNA) derived from the central nervous system from entering th...
Targeted immunotherapy for glioblastoma involving whole tumor-derived autologous cells in the upfront setting after craniotomy
Targeted immunotherapy for glioblastoma involving whole tumor-derived autologous cells in the upfront setting after craniotomy
To date, immunotherapeutic approaches in glioblastoma (GBM) have had limited clinical efficacy as compared to other solid ...
Treatment and survival of patients with small cell lung cancer and brain metastasis
Treatment and survival of patients with small cell lung cancer and brain metastasis
To elucidate treatment patterns and their outcomes in patients with small cell lung cancer (SCLC) and brain metastasis (BM...
Effects of intrathecal pemetrexed on the survival of patients with leptomeningeal metastasis from lung adenocarcinoma: a propensity score matching analysis
Effects of intrathecal pemetrexed on the survival of patients with leptomeningeal metastasis from lung adenocarcinoma: a propensity score matching analysis
To explore the impact of intrathecal pemetrexed (IP) on the survival of lung adenocarcinoma (LUAC) patients with leptomeni...
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow
Although pediatric low-grade gliomas (pLGG) are the most common pediatric brain tumors, patient-derived cell lines reflect...
Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT
Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT
Incidence, prevalence, and survival are population-based statistics describing cancer burden. The National Cancer Institut...
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