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Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
Mutations in the leucine-rich repeat kinase 2 (LRRK2) that increase kinase activity are associated with some forms of Park...
A novel tool for the unbiased characterization of epithelial monolayer development in culture
A novel tool for the unbiased characterization of epithelial monolayer development in culture
The function of an epithelial tissue is intertwined with its architecture. Epithelial tissues are often described as pseud...
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
Targeting of Hmo1 to subcompartments of the budding yeast nucleolus
The nucleolus is a multi-layered, membrane-less organelle made up of liquid-like biogenesis compartments surrounding an ar...
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice
To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1,...
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Mechanically primed cells transfer memory to fibrous matrices for invasion across environments of distinct stiffness and dimensionality
Cells sense and migrate across mechanically dissimilar environments throughout development and disease progression. Howeve...
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Spatio-temporal regulation of endocytic protein assembly by SH3 domains in yeast
Clathrin-mediated endocytosis is a conserved eukaryotic membrane trafficking pathway that is driven by a sequentially asse...
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