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ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
ROS Generation in Mitochondria and Cytosol during Optogenetic Cytosol Alkalization in Human Cells
Optogenetics allows a precise control of a vast variety of cellular processes in excitable and non-excitable cells, in par...
Expression and Stabilization of Recombinant Human C3aR Receptor
Expression and Stabilization of Recombinant Human C3aR Receptor
The complement system is an important part of the immune system that controls the body’s defense against pathogens. ...
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
Synthesis of New Uracil Derivatives with Antiviral and Anticancer Potential
The need for new effective compounds that can serve as prototype drugs for the treatment of viral infections and various t...
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
Membrane Curvature Controls the Efficiency of Oxidative Phosphorylation System
This paper analyzes the structural and functional organization of mitochondria. It is shown that deformation of membrane l...
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
Investigating the Quantitative PALM Applicability for Studies of Protein Oligomerization in Different Conditions
In this work we aimed to investigate in silico the influence of the common experimental factors on the determination of th...
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Role of K and BK Channels in the Effects of Sodium Butyrate on Colon Motility in a Mouse Model of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a multifactorial disorder, with a high socioeconomic impact, characterized by chronic ab...
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
Optimization of Angiotensin II Receptor Type 1 Production for Biophysical Studies
The class of G protein-coupled receptors (GPCRs) represents a ubiquitous family of membrane proteins that selectively inte...
Line Tension of Pore Edge in Membrane on Solid Support
Line Tension of Pore Edge in Membrane on Solid Support
Controlled formation of through pores in bilayer lipid membranes is a key stage of various biotechnological techniques. Ex...
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
Optimizing Oxygenic Photosynthesis: pH-Regulation of Electron Transport in Chloroplasts
The work is devoted to the mathematical modeling of the regulation of electron and proton transport in the thylakoid membr...
Recombinant Protein Biosensors of Cell Membrane Lipids
Recombinant Protein Biosensors of Cell Membrane Lipids
Specific patterns of lipid distribution in cell membranes determine their structural and signaling roles and ensure the in...
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
MKT-077 Suppresses the Functional Activity of Isolated Mouse Skeletal Muscle Mitochondria
This study demonstrates the effect of the rhodocyanine derivative MKT-077 on the function of isolated mitochondria from mo...
Comparison of Functional and Proliferative Activity of hTERT-NK and iCasp9-NK Cells
Comparison of Functional and Proliferative Activity of hTERT-NK and iCasp9-NK Cells
Cancer progression is often accompanied with the acquisition of functional anergy by natural killer (NK) cells and their a...
Thermodynamics of a Lipid Membrane with Curvature
Thermodynamics of a Lipid Membrane with Curvature
The work considers the transverse bending of the surface of a bilayer lipid membrane and the lateral pressure profile in t...
Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
The ability of NK cells to establish antigen-specific responses has been demonstrated in various infections. NK cell recep...
Formation of Pores in Membranes Asymmetrical in Lipid Composition of Monolayers
Formation of Pores in Membranes Asymmetrical in Lipid Composition of Monolayers
Plasma membranes perform a barrier function in cells, preventing free exchange between the external environment and the in...
Effect of Carbon Monoxide on ATP-Evoked Activity in Rat Trigeminal Afferents
Effect of Carbon Monoxide on ATP-Evoked Activity in Rat Trigeminal Afferents
Carbon monoxide (CO) is an endogenous molecule that plays a regulatory role in a number of physiological and pathological ...
Wide-Angle X-Ray Scattering Comparative Analysis of Haloarchaeal Purple and Claret Membranes
Wide-Angle X-Ray Scattering Comparative Analysis of Haloarchaeal Purple and Claret Membranes
We present the results of the study of the structural distinctions between the purple membrane (PM) of Halobacterium salin...
Evaluation of the Effect of Geometrical Configuration and Charge of Opioid Antagonists on Their Binding to Receptors
Evaluation of the Effect of Geometrical Configuration and Charge of Opioid Antagonists on Their Binding to Receptors
The effect of the geometric configuration and charge of membrane opioid receptor (OR) agonists and antagonists on binding ...
The Protective Role of Mangiferin and -Cinnamic Acid against Oxidative Stress in Wild Type and Mutant Strains
The Protective Role of Mangiferin and -Cinnamic Acid against Oxidative Stress in Wild Type and Mutant Strains
During cellular metabolism, reactive oxygen species and nitrogen species are produced which inherently results in oxidativ...
Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
The superfamily of membrane proteins known as P-loop channels encompasses potassium, sodium, and calcium channels, as well...
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
The paper overviews the results of computational studies of the molecular mechanisms underlying the adaptation of model ce...
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Neurodegenerative diseases, along with cardiovascular and oncological pathologies, are one of the most acute problems of m...
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Planar lipid bilayers are unique tools designed for modeling cell membranes and electrophysiological studies of ion channe...
Structure and Functions of the OTOP1 Proton Channel
Structure and Functions of the OTOP1 Proton Channel
OTOP1 belongs to the otopetrin family of membrane proteins that form proton channels in cells of diverse types. In mammals...
Evolutionary Choice between Cholesterol and Ergosterol
Evolutionary Choice between Cholesterol and Ergosterol
Sterol biosynthesis has evolved early in the history of eukaryotes. In most animals, as well as in primitive fungi, the ma...
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
The complex mechanism called hemostasis evolved in living organisms to prevent blood loss when a blood vessel is damaged. ...
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Membranes of living cells, or biological membranes, are unique molecular systems in which the functioning of all molecules...
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Illuminated giant cells of Characeae produce alternating areas with H+-pump activity and zones of high H+/OH– conduc...
Action of Serotonin Precursor Synthesis 5-Oxytryptophan on EPSP Recorded in Premotor Interneurons of Snail after Formation of Conditioned Defensive Reflex
Action of Serotonin Precursor Synthesis 5-Oxytryptophan on EPSP Recorded in Premotor Interneurons of Snail after Formation of Conditioned Defensive Reflex
A quantitative study of subthreshold excitatory postsynaptic potentials (EPSP) recorded intracellularly in giant premotor ...
Study of the Spectral Characteristics of the Plant Cell Surface: Occurrence of Azulenes and Biogenic Amines
Study of the Spectral Characteristics of the Plant Cell Surface: Occurrence of Azulenes and Biogenic Amines
The spectral characteristics of plant surface cells of different evolutionary levels, from unicellular (diatom algae and s...
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