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Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management
Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management
Ischaemic stroke is one of the key causes of morbidity and mortality worldwide. Although rapid reperfusion through thrombo...
Outcomes of patients with myeloproliferative neoplasms and critical limb ischemia: insights from the National readmissions database
Outcomes of patients with myeloproliferative neoplasms and critical limb ischemia: insights from the National readmissions database
Patients with myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and m...
Khorana risk score in lung cancer patients treated with immune checkpoint inhibitors: a real-world study
Khorana risk score in lung cancer patients treated with immune checkpoint inhibitors: a real-world study
Lung cancer patients are at increased risk of venous thromboembolism (VTE) and arterial thrombosis, particularly when trea...
Acute myocardial infarction in patients with cancer: outcomes and P2Y12 inhibition
Acute myocardial infarction in patients with cancer: outcomes and P2Y12 inhibition
Cancer patients are at an elevated risk of bleeding and ischemic events. There are limited comparative real-world data on ...
Efficacy and safety of intravenous tirofiban combined with reperfusion therapy versus reperfusion therapy alone in acute ischemic stroke: a meta-analysis of randomized controlled trials
Efficacy and safety of intravenous tirofiban combined with reperfusion therapy versus reperfusion therapy alone in acute ischemic stroke: a meta-analysis of randomized controlled trials
Several studies have shown an additional benefit of tirofiban administration in patients with acute ischemic stroke (AIS) ...
Thrombin generation and clot lysis time to predict outcomes in patients undergoing transcatheter aortic valve implantation
Thrombin generation and clot lysis time to predict outcomes in patients undergoing transcatheter aortic valve implantation
Transcatheter aortic valve implantation (TAVI) is an established treatment method in patients with severe aortic stenosis ...
Evaluation of unfractionated heparin dosing using an antifactor-Xa-based protocol in non-obese vs. obese patients for acute venous thromboembolism
Evaluation of unfractionated heparin dosing using an antifactor-Xa-based protocol in non-obese vs. obese patients for acute venous thromboembolism
The pharmacokinetic profile of heparin may result in supratherapeutic antifactor-Xa levels using total weight-based protoc...
The severity of ischemic stroke and risk of all-cause mortality in patients with atrial fibrillation on different oral anticoagulant treatments admitted to the emergency department
The severity of ischemic stroke and risk of all-cause mortality in patients with atrial fibrillation on different oral anticoagulant treatments admitted to the emergency department
Although direct oral anticoagulants (DOACs) are non-inferior to Vitamin K antagonists (VKA) in preventing ischemic stroke ...
The use of oral anticoagulation at the time of acute COVID-19 infection and subsequent development of long-COVID/post-acute sequelae of SARS-CoV-2 infection
The use of oral anticoagulation at the time of acute COVID-19 infection and subsequent development of long-COVID/post-acute sequelae of SARS-CoV-2 infection
Long COVID (LC) or post-acute sequelae of SARS-CoV-2 infection (PASC) is defined as ongoing, relapsing or new symptoms/con...
Left atrial appendage occlusion in patients with cancer
Left atrial appendage occlusion in patients with cancer
Atrial fibrillation (AF) and malignancy share a complex relationship, significantly complicating patient management. Patie...
Treatment of isolated distal deep vein thrombosis: an international survey of healthcare professionals
Treatment of isolated distal deep vein thrombosis: an international survey of healthcare professionals
Isolated distal deep venous thrombosis (iDDVT) is an infra-popliteal DVT without pulmonary embolism (PE). It is a common c...
Venous thromboembolic complications in patients newly diagnosed with cholangiocarcinoma
Venous thromboembolic complications in patients newly diagnosed with cholangiocarcinoma
Cholangiocarcinoma (CCA) is an uncommon cancer, with limited data available on the incidence of cancer-associated thrombos...
Exploring the relationship of platelet aggregation function with efficacy and safety outcomes following the administration of prasugrel and clopidogrel in patients with thrombotic stroke: a post hoc analysis of PRASTRO pooled studies
Exploring the relationship of platelet aggregation function with efficacy and safety outcomes following the administration of prasugrel and clopidogrel in patients with thrombotic stroke: a post hoc analysis of PRASTRO pooled studies
The P2Y12 receptor inhibitor prasugrel was approved for thrombotic stroke in Japan following the phase 3 clinical trials P...
Direct oral anticoagulants do not affect miR-27a-3p expression, a regulator of coagulation cascade, in atrial fibrillation patients
Direct oral anticoagulants do not affect miR-27a-3p expression, a regulator of coagulation cascade, in atrial fibrillation patients
miR-27a-3p targets several proteins on the coagulation cascade. The potential effect of direct oral anticoagulants (DOACs)...
Associations between fibrinogen levels and the risk of all-cause mortality: a long-term cohort study
Associations between fibrinogen levels and the risk of all-cause mortality: a long-term cohort study
Although prior research has investigated the link between fibrinogen and mortality risk, there is a notable lack of long-t...
Comparison of safety and efficacy of ultrasound-accelerated thrombolysis vs. standard catheter-directed thrombolysis for the management of acute pulmonary embolism - a systematic review and meta-analysis
Comparison of safety and efficacy of ultrasound-accelerated thrombolysis vs. standard catheter-directed thrombolysis for the management of acute pulmonary embolism - a systematic review and meta-analysis
Standard catheter-directed thrombolysis (SCDT) and Ultrasound-assisted thrombolysis (USAT) are used in intermediate and hi...
Association between stable angina pectoris and gastric cancer: two-sample bidirectional mendelian randomization study
Association between stable angina pectoris and gastric cancer: two-sample bidirectional mendelian randomization study
To explore the possible causal link between stable angina pectoris (SAP) and gastric cancer (GC) through Mendelian randomi...
Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions
Atrial fibrillation and ischemic stroke in cancer: the latest scientific evidence, current management, and future directions
Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for ischemic stroke. Atrial fibrillat...
Advancements in research on the thrombo-inflammation mechanisms mediated by factor XII in ischemic stroke
Advancements in research on the thrombo-inflammation mechanisms mediated by factor XII in ischemic stroke
Ischemic stroke (IS) is a major cause of mortality and disability, with thrombo-inflammation constituting a core pathophys...
The current status and future perspective of extended anticoagulation therapy for cancer-associated venous thromboembolism
The current status and future perspective of extended anticoagulation therapy for cancer-associated venous thromboembolism
Cancer-associated venous thromboembolism (VTE) is one of important complications in cancer patients, with implications for...
New interest in fibrinogen as an ischemic risk factor
New interest in fibrinogen as an ischemic risk factor
Platelet-fibrin clot formation is a key process in acute arterial thrombosis. The relationship between thrombin-induced pl...
Enhanced thrombin generation induced by extracellular vesicles from severe COVID−19 cases
Enhanced thrombin generation induced by extracellular vesicles from severe COVID−19 cases
Authors and AffiliationsUniversity of Sao Paulo Medical School, Sao Paulo, BrazilBárbara Gomes Barion & Thaís Dourado ...
The use of non-vitamin K antagonist oral anticoagulants in chronic thromboembolic pulmonary hypertension: an updated meta-analysis
The use of non-vitamin K antagonist oral anticoagulants in chronic thromboembolic pulmonary hypertension: an updated meta-analysis
Studies have demonstrated the beneficial effects of non-vitamin K antagonist oral anticoagulants (NOACs) for the treatment...
Bleeding outcomes in critically ill patients on heparin with discordant aPTT and anti-Xa activity
Bleeding outcomes in critically ill patients on heparin with discordant aPTT and anti-Xa activity
• Hospitalized patients may exhibit discordance in aPTT and anti-Xa activities while on UFH. • In this study, ...
ASTRAL scale for predicting prognosis following intravenous thrombolysis with anterior versus posterior circulation acute ischemic stroke
ASTRAL scale for predicting prognosis following intravenous thrombolysis with anterior versus posterior circulation acute ischemic stroke
In this study, we compared whether there was any difference between the ASTRAL(Acute Stroke Registry and Analysis of Lausa...
The protective effects of annexin A1 against oxidized-LDL-induced monocytes adhesion to endothelial cells: implication in atherosclerosis
The protective effects of annexin A1 against oxidized-LDL-induced monocytes adhesion to endothelial cells: implication in atherosclerosis
Oxidized low-density lipoprotein (ox-LDL)-associated endothelial dysfunction is a critical factor in the initiation and pr...
Development of the Pulmonary Embolism Progression (PEP) score for predicting short-term clinical deterioration in intermediate-risk pulmonary embolism: a single-center retrospective study
Development of the Pulmonary Embolism Progression (PEP) score for predicting short-term clinical deterioration in intermediate-risk pulmonary embolism: a single-center retrospective study
Accurate risk stratification in acute intermediate-risk pulmonary embolism (PE) is essential. Current prediction scores la...
Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors
Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors
Factor XIIa (FXIIa) is a plasma serine protease within the contact activation pathway. Inhibiting FXIIa could offer a viab...
Optimal intravenous antiplatelet therapy in patients with ST-elevation myocardial infarction: is the picture becoming clearer?
Optimal intravenous antiplatelet therapy in patients with ST-elevation myocardial infarction: is the picture becoming clearer?
In patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous c...
Equivalent thrombotic risk with Warfarin, Dabigatran, or Enoxaparin after failure of initial direct oral anticoagulation (DOAC) therapy
Equivalent thrombotic risk with Warfarin, Dabigatran, or Enoxaparin after failure of initial direct oral anticoagulation (DOAC) therapy
The direct oral anticoagulants (DOACs) are now commonly regarded as first line anticoagulants in most cases of venous thro...
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