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Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication
Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication
<p>Mutations in the complement factor H (<italic>CFH</italic>) gene are associated with complement dysre...
Biomarkers and computational models for predicting efficacy to tumor ICI immunotherapy
Biomarkers and computational models for predicting efficacy to tumor ICI immunotherapy
<p>Numerous studies have shown that immune checkpoint inhibitor (ICI) immunotherapy has great potential as a cancer ...
Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study
Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study
<sec><title>Objective</title><p>Emerging evidence has provided compelling evidence linking gut mic...
Expression of immune related genes and possible regulatory mechanisms in different stages of non-alcoholic fatty liver disease
Expression of immune related genes and possible regulatory mechanisms in different stages of non-alcoholic fatty liver disease
<sec><title>Background</title><p>Non-alcoholic fatty liver disease (NAFLD), which includes simple ...
An updated management approach of Pompe disease patients with high-sustained anti-rhGAA IgG antibody titers: experience with bortezomib-based immunomodulation
An updated management approach of Pompe disease patients with high-sustained anti-rhGAA IgG antibody titers: experience with bortezomib-based immunomodulation
<sec><title>Introduction</title><p>High sustained anti-rhGAA antibody titers (HSAT; ≥12,800) are d...
CD64 plays a key role in diabetic wound healing
CD64 plays a key role in diabetic wound healing
<sec><title>Introduction</title><p>Wound healing poses a clinical challenge in diabetes mellitus (...
Neoadjuvant therapy with chemotherapy and immune checkpoint inhibitor for laryngeal function preservation in locally advanced hypopharyngeal cancer
Neoadjuvant therapy with chemotherapy and immune checkpoint inhibitor for laryngeal function preservation in locally advanced hypopharyngeal cancer
<sec><title>Purpose</title><p>To evaluate the efficacy and laryngeal function preservation of neoa...
A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation
A mini-review: phosphodiesterases in charge to balance intracellular cAMP during T-cell activation
<p>T-cell activation is a pivotal process of the adaptive immune response with 3′,5′-cyclic adenosine monophosphate ...
Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background
Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background
<sec><title>Introduction</title><p>Systemic Lupus Erythematosus (SLE) impacts the central nervous ...
Autoimmune nodopathy with anti-contactin 1 antibody characterized by cerebellar dysarthria: a case report and literature review
Autoimmune nodopathy with anti-contactin 1 antibody characterized by cerebellar dysarthria: a case report and literature review
<sec><title>Background</title><p>Autoimmune nodopathy (AN) has emerged as a novel diagnostic categ...
Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms
Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms
<p>Air pollution plays an important role in the mortality and morbidity of chronic airway diseases, such as asthma a...
Detection of Staphylococcus aureus virulence gene pvl based on CRISPR strip
Detection of Staphylococcus aureus virulence gene pvl based on CRISPR strip
<sec><title>Introduction</title><p><italic>Staphylococcus aureus</italic> (<italic&...
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity
Distinct functional neutrophil phenotypes in sepsis patients correlate with disease severity
<sec><title>Purpose</title><p>Sepsis is a clinical syndrome defined as life-threatening organ dysf...
Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018
Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018
<sec><title>Background</title><p>There is a growing acknowledgment of the potential influence of a...
Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity
Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity
<sec><title>Background</title><p>Mast cells (MCs) and neural cells (NCs) are important in a keloid...
Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity
Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity
<sec><title>Introduction</title><p>Psoriasis is a T-cell mediated autoimmune skin disease. <ita...
Progression of Notch signaling regulation of B cells under radiation exposure
Progression of Notch signaling regulation of B cells under radiation exposure
<p>With the continuous development of nuclear technology, the radiation exposure caused by radiation therapy is a se...
GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection
GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection
<p>Naïve CD8<sup>+</sup> T cells need to undergo a complex and coordinated differentiation program to ga...
Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype
Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype
<p>Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (...
Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes
Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes
<sec><title>Introduction</title><p>Diabetes mellitus (DM) is recognized as one of the oldest chron...
Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data
Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data
BackgroundPrior epidemiological studies have established a correlation between inflammatory cytokines and inflammatory bow...
Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution
Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution
BackgroundDiffuse large B-cell lymphoma (DLBCL) represents the most prevalent form of aggressive non-Hodgkin lymphoma. Des...
The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation
The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation
IntroductionThe killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, f...
Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda
Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda
Parasitoid wasps control pests via a precise attack leading to the death of the pest. However, parasitoid larvae exhibit s...
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
IntroductionExtracorporal Photophoresis (ECP) is in clinical use for steroid-refractory and steroid-dependent acute GVHD (...
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice
IntroductionPulmonary granuloma diseases caused by Mycobacterium abscessus (M. abscessus) have increased in past decades, ...
Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD
Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD
IntroductionSince the outbreak of SARS-CoV-2, vaccines have demonstrated their effectiveness in resisting virus infection,...
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with suscep...
Deciphering the human antibody response against Burkholderia pseudomallei during melioidosis using a comprehensive immunoproteome approach
Deciphering the human antibody response against Burkholderia pseudomallei during melioidosis using a comprehensive immunoproteome approach
IntroductionThe environmental bacterium Burkholderia pseudomallei causes the often fatal and massively underreported infec...
Recombinant antigen P29 of Echinococcus granulosus induces Th1, Tc1, and Th17 cell immune responses in sheep
Recombinant antigen P29 of Echinococcus granulosus induces Th1, Tc1, and Th17 cell immune responses in sheep
Echinococcosis is a common human and animal parasitic disease that seriously endangers human health and animal husbandry. ...
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