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Naturally selected CD7-directed CAR-T bridging allo-HSCT in refractory acute myeloid leukemia: a case report and review
Naturally selected CD7-directed CAR-T bridging allo-HSCT in refractory acute myeloid leukemia: a case report and review
Relapsed/refractory acute myeloid leukemia (R/R-AML) has a poor prognosis. CD7 is expressed in leukemic cells in 30% of pa...
Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma
Real-world study and prognostic analysis of angioimmunoblastic T-cell lymphoma
ObjectiveTo analyze the clinical prognostic factors and treatments for angioimmunoblastic T-cell lymphoma (AITL) and devel...
Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury
Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury
Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species...
HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance
HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance
IntroductionUrothelial bladder cancer is frequent and exhibits diverse prognoses influenced by molecular subtypes, urothel...
Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
Despite the employment of extensive therapeutic strategies, OSCC recurrence and mortality rates persist at high levels. Th...
Case report: The impact of dissociated response of immunotherapy on the treatment strategy of advanced head and neck cancer
Case report: The impact of dissociated response of immunotherapy on the treatment strategy of advanced head and neck cancer
Some special therapeutic responses may appear during immunotherapy, such as hyperprogression, pseudoprogression and so on....
Immunoregulation role of the erythroid cells
Immunoregulation role of the erythroid cells
Erythroid cells are the most abundant cells in the human body. In addition to their established function in gas-transporta...
Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150
Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150
The specificity of cytokine and immunoreceptor signaling frequently depends upon receptor recruitment of select adaptor pr...
Reinvesting the cellular properties of human amniotic epithelial cells and their therapeutic innovations
Reinvesting the cellular properties of human amniotic epithelial cells and their therapeutic innovations
Human amniotic epithelial cells (hAECs) have shown promising therapeutic effects in numerous studies on various diseases d...
Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells
Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells
Computational strategies to extract meaningful biological information from multiomics data are in great demand for effecti...
PD-1 and CTLA-4 serve as major gatekeepers for effector and cytotoxic T-cell potentiation by limiting a CXCL9/10-CXCR3-IFNγ positive feedback loop
PD-1 and CTLA-4 serve as major gatekeepers for effector and cytotoxic T-cell potentiation by limiting a CXCL9/10-CXCR3-IFNγ positive feedback loop
CXCR3 is a chemokine receptor with three ligands: CXCL9, CXCL10 and CXCL11. We report that in addition to attracting CXCR3...
Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response
Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response
IntroductionBreast cancer is a significant public health problem around the world, ranking first in deaths due to cancer i...
Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024
Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024
BackgroundRegulated cell death (RCD) is a genetically controlled form of cell death that plays an important role in organo...
Functional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
Functional genomic analysis of the 68-1 RhCMV-Mycobacteria tuberculosis vaccine reveals an IL-15 response signature that is conserved with vector attenuation
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is a deadly infectious disease having a major impact on glob...
Contribution of tryptophan and its metabolites to transplant outcome: a mini-review
Contribution of tryptophan and its metabolites to transplant outcome: a mini-review
Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attain...
Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma
Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma
IntroductionLung adenocarcinoma, a prevalent and lethal malignancy globally, is characterized by significant tumor heterog...
Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow
Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow
PurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing im...
Making the effect visible – OX40 targeting nanobodies for in vivo imaging of activated T cells
Making the effect visible – OX40 targeting nanobodies for in vivo imaging of activated T cells
PurposeHuman OX40 (hOX40/CD134), a member of the TNF receptor superfamily, is mainly expressed on activated T lymphocytes....
Retraction: Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 following ventilator associated pneumonia
A Retraction of the Original Research Article:  Macrophages depletion alleviates lung injury by modulating AKT3/GXP4 follo...
Retraction: Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction
Content: A Retraction of the Original Research Article:  Tregs depletion aggravates activation of astrocytes by modulating...
Single cell multi-omic analysis identifies key genes differentially expressed in innate lymphoid cells from COVID-19 patients
Single cell multi-omic analysis identifies key genes differentially expressed in innate lymphoid cells from COVID-19 patients
IntroductionInnate lymphoid cells (ILCs) are enriched at mucosal surfaces where they respond rapidly to environmental stim...
Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
BackgroundCD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining s...
Vitamin D and allergic diseases
Vitamin D and allergic diseases
In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-solu...
Nephrotoxicity of targeted therapy used to treat lung cancer
Nephrotoxicity of targeted therapy used to treat lung cancer
Lung cancer is the leading cause of cancer-related death worldwide, especially non-small cell lung cancer. Early diagnosis...
Role of the Pseudomonas plecoglossicida fliL gene in immune response of infected hybrid groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)
Role of the Pseudomonas plecoglossicida fliL gene in immune response of infected hybrid groupers (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂)
Pseudomonas plecoglossicida, a gram-negative bacterium, is the main pathogen of visceral white-point disease in marine fis...
Advancing immunotherapy for melanoma: the critical role of single-cell analysis in identifying predictive biomarkers
Advancing immunotherapy for melanoma: the critical role of single-cell analysis in identifying predictive biomarkers
Melanoma, a malignant skin cancer arising from melanocytes, exhibits rapid metastasis and a high mortality rate, especiall...
The therapeutic and biomarker significance of ferroptosis in chronic myeloid leukemia
The therapeutic and biomarker significance of ferroptosis in chronic myeloid leukemia
BackgroundThe relationship between ferroptosis and the progression and treatment of hematological tumors has been extensiv...
Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment
Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment
BackgroundAccumulating evidence reveals mitochondrial dysfunction exacerbates intestinal barrier dysfunction and inflammat...
Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer
Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer
The aim of this study was to evaluate the mutation spectrum of homologous recombination repair (HRR) genes and its associa...
Navigating the landscape of the unfolded protein response in CD8+ T cells
Navigating the landscape of the unfolded protein response in CD8+ T cells
Endoplasmic reticulum stress occurs due to large amounts of misfolded proteins, hypoxia, nutrient deprivation, and more. T...
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