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Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
Relapsed and refractory acute myeloid leukemia (AML) carries a dismal prognosis. CAR T cells have shown limited efficacy i...
Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients
Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients
Results of conventional induction chemotherapies in primary central nervous system lymphoma (PCNSL) need to be improved. I...
Landscape of biallelic DNMT3A mutant myeloid neoplasms
Landscape of biallelic DNMT3A mutant myeloid neoplasms
DNA methyltransferase 3 A mutations (DNMT3AMT) are frequent in myeloid neoplasia (MN) and mostly heterozygous. Ho...
Targeting GPRC5D for multiple myeloma therapy
Targeting GPRC5D for multiple myeloma therapy
Given its nearly ubiquitous expression on plasma cells and limited expression on essential normal tissue, the G protein-co...
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due...
Advances in targeting histone deacetylase for treatment of solid tumors
Advances in targeting histone deacetylase for treatment of solid tumors
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have g...
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously ch...
Targeting FGFR for cancer therapy
Targeting FGFR for cancer therapy
The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dys...
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant...
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment pa...
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplant...
Vaccines: a promising therapy for myelodysplastic syndrome
Vaccines: a promising therapy for myelodysplastic syndrome
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and cli...
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental f...
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumo...
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses is a...
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grow...
Genitourinary cancers updates: highlights from ASCO 2023
Genitourinary cancers updates: highlights from ASCO 2023
Significant scientific advances in immunotherapy and targeted therapy approaches have improved clinical outcomes and incre...
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is a type of hematologic tumor with malignant proliferation of hematopoietic p...
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Qian Zhu, Ai-Lin Zhong and Hao Hu have contributed equally to this work.State Key Laboratory of Oncology in Southern China...
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Chimeric antigen receptor T-cell therapy (CAR-T) has been successful in treating relapsed/refractory B-cell lymphomas. How...
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector f...
CRISPR screening in hematology research: from bulk to single-cell level
CRISPR screening in hematology research: from bulk to single-cell level
The CRISPR genome editing technology has revolutionized the way gene function is studied. Genome editing can be achieved i...
Correction: Non-T-depleted haploidentical transplantation with post-transplant cyclophosphamide in patients with secondary versus de novo AML in first complete remission: a study from the ALWP/EBMT
Correction: Non-T-depleted haploidentical transplantation with post-transplant cyclophosphamide in patients with secondary versus de novo AML in first complete remission: a study from the ALWP/EBMT
Division of Hematology, Sheba Medical Center, Tel Hashomer, IsraelArnon NaglerEBMT Paris Study Office, Department of Haema...
Correction: Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy
Correction: Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA
Genomic profiling of post-transplant lymphoproliferative disorders using cell-free DNA
Diagnosing post-transplant lymphoproliferative disorder (PTLD) is challenging and often requires invasive procedures. Anal...
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and surviv...
CT041 CAR T cell therapy for Claudin18.2-positive metastatic pancreatic cancer
CT041 CAR T cell therapy for Claudin18.2-positive metastatic pancreatic cancer
Pancreatic cancer lacks effective therapy. Here, we reported two metastatic pancreatic cancer patients administrated with ...
Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy
Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy
In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become a new pillar of cancer treatment follo...
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