SCI Abstract

search
+
Recent advances in CAR-MSCs: the new engine of cellular immunotherapy evolution
Recent advances in CAR-MSCs: the new engine of cellular immunotherapy evolution
In recent years, the development of chimeric antigen receptor (CAR) technology has greatly promoted the progress of cellul...
Challenges and limitations of chimeric antigen receptor T-cell therapies in solid tumors: why are approvals restricted to hematologic malignancies?
Challenges and limitations of chimeric antigen receptor T-cell therapies in solid tumors: why are approvals restricted to hematologic malignancies?
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic malignancies, offering a ...
The neuro-immune axis in cancer: from mechanisms to therapeutic opportunities
The neuro-immune axis in cancer: from mechanisms to therapeutic opportunities
In recent years, neural mechanisms involved in tumor initiation, progression, and immune regulation have garnered growing ...
PSMA-targeted CAR-macrophages drive glycolytic reprogramming for enhanced prostate cancer immunotherapy
PSMA-targeted CAR-macrophages drive glycolytic reprogramming for enhanced prostate cancer immunotherapy
Although chimeric antigen receptor (CAR)-T cells have demonstrated remarkable efficacy against hematologic malignancies, t...
The genomic and epigenomic abnormalities of plasma cfDNA as liquid biopsy biomarkers to detect hepatocellular carcinoma: a multicenter cohort study
The genomic and epigenomic abnormalities of plasma cfDNA as liquid biopsy biomarkers to detect hepatocellular carcinoma: a multicenter cohort study
Circulating tumor DNA (ctDNA) is a promising biomarker for early cancer detection; however, the optimal biomarker approach...
Disruption of the sorcin‒PAX5 protein‒protein interaction induces ferroptosis by promoting the FBXL12-mediated ubiquitination of ALDH1A1 in pancreatic cancer
Disruption of the sorcin‒PAX5 protein‒protein interaction induces ferroptosis by promoting the FBXL12-mediated ubiquitination of ALDH1A1 in pancreatic cancer
Pancreatic cancer is one of the most malignant cancers, and limited therapeutic options are available. The induction of fe...
Circulating tumor DNA in lymphoma: technologies and applications
Circulating tumor DNA in lymphoma: technologies and applications
Lymphoma, a malignant tumor derived from lymphocytes and lymphoid tissues, presents with complex and heterogeneous clinica...
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
Relapsed and refractory acute myeloid leukemia (AML) carries a dismal prognosis. CAR T cells have shown limited efficacy i...
Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients
Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients
Results of conventional induction chemotherapies in primary central nervous system lymphoma (PCNSL) need to be improved. I...
Landscape of biallelic DNMT3A mutant myeloid neoplasms
Landscape of biallelic DNMT3A mutant myeloid neoplasms
DNA methyltransferase 3 A mutations (DNMT3AMT) are frequent in myeloid neoplasia (MN) and mostly heterozygous. Ho...
Targeting GPRC5D for multiple myeloma therapy
Targeting GPRC5D for multiple myeloma therapy
Given its nearly ubiquitous expression on plasma cells and limited expression on essential normal tissue, the G protein-co...
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due...
Advances in targeting histone deacetylase for treatment of solid tumors
Advances in targeting histone deacetylase for treatment of solid tumors
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have g...
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously ch...
Targeting FGFR for cancer therapy
Targeting FGFR for cancer therapy
The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dys...
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant...
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have revolutionized the treatment pa...
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry
The use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplant...
Vaccines: a promising therapy for myelodysplastic syndrome
Vaccines: a promising therapy for myelodysplastic syndrome
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and cli...
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
Cancer is a complex disease resulting from abnormal cell growth that is induced by a number of genetic and environmental f...
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
Nanobody-based trispecific T cell engager (Nb-TriTE) enhances therapeutic efficacy by overcoming tumor-mediated immunosuppression
T cell engagers (TCEs) have been established as an emerging modality for hematologic malignancies, but solid tumo...
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses is a...
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment
Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grow...
Genitourinary cancers updates: highlights from ASCO 2023
Genitourinary cancers updates: highlights from ASCO 2023
Significant scientific advances in immunotherapy and targeted therapy approaches have improved clinical outcomes and incre...
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
Direct inhibition of dioxygenases TET1 by the rheumatoid arthritis drug auranofin selectively induces cancer cell death in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is a type of hematologic tumor with malignant proliferation of hematopoietic p...
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Retraction Note: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma
Qian Zhu, Ai-Lin Zhong and Hao Hu have contributed equally to this work.State Key Laboratory of Oncology in Southern China...
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Outcomes of patients with secondary central nervous system lymphoma following CAR T-cell therapy: a multicenter cohort study
Chimeric antigen receptor T-cell therapy (CAR-T) has been successful in treating relapsed/refractory B-cell lymphomas. How...
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector f...
Load More
format_indent_increase