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Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions
The present study uses electron microscopy to document ultrastructural characteristics of hippocampal GABAergic inhibitory...
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration
Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated...
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice
Chronic exposure to glucocorticoids in response to long-term stress is thought to be a risk factor for major depression. D...
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity
Understanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and extern...
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system
The mechanisms through which systemic inflammation exerts its effect on the central nervous system (CNS) are still not com...
Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Man...
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia
The cerebellum plays an important role in cognitive and social functioning. Childhood damage in the cerebellum increases t...
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and ...
The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 ...
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
The duality of amyloid-β: its role in normal and Alzheimer’s disease states
Alzheimer’s disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrup...
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway
Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders, but the precise underlying pat...
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
Crucial role of TFAP2B in the nervous system for regulating NREM sleep
The AP-2 transcription factors are crucial for regulating sleep in both vertebrate and invertebrate animals. In mice, loss...
Spermidine treatment: induction of autophagy but also apoptosis?
Spermidine treatment: induction of autophagy but also apoptosis?
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that cause...
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic...
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Neuroligin (NLGN) 3 is a postsynaptic cell adhesion protein organizing synapse formation through two different types of tr...
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment
Cognitive dysfunction increases as menopause progresses. We previously found that estrogen receptors (ERs) contribute to d...
Effects of MAP4K inhibition on neurite outgrowth
Effects of MAP4K inhibition on neurite outgrowth
Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transductio...
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
Necroptosis is known to play an important role in the pathophysiology of cerebral ischemia; however, its role in the occur...
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) v...
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-ons...
Impact of volume and expression time in an AAV-delivered channelrhodopsin
Impact of volume and expression time in an AAV-delivered channelrhodopsin
Optogenetics has revolutionised neuroscience research, but at the same time has brought a plethora of new variables to con...
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called tempora...
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo
Calcium ions (Ca2+) play pivotal roles in regulating diverse brain functions, including cognition, emotion, locomotion, an...
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Anterior cingulate cortex regulates pain catastrophizing-like behaviors in rats
Negative pain expectation including pain catastrophizing is a well-known clinical phenomenon whereby patients amplify the ...
Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Rab11a in the spinal cord: an essential contributor to complete Freund’s adjuvant-induced inflammatory pain in mice
Inflammatory pain is a commonly observed clinical symptom in a range of acute and chronic diseases. However, the mechanism...
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes...
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study
Novelty-induced memory consolidation is a well-established phenomenon that depends on the activation of a locus coeruleus-...
Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice
Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive mo...
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
The insula and anterior cingulate cortex (ACC) are brain regions that undergo structural and functional reorganization in ...
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by Aβ deposition, tauopathy, neuroinflamm...
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