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Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting
Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting
Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) o...
Evaluation of hospital pharmacists’ activities using additional reimbursement for infection prevention as an indicator in small and medium-sized hospitals
Evaluation of hospital pharmacists’ activities using additional reimbursement for infection prevention as an indicator in small and medium-sized hospitals
Hospitals in Japan established the healthcare delivery system from FY 2018 to 2021 by acquiring an additional reimbursemen...
In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities
In-vitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities
Multidrug-resistant bacterial strains cause several serious infections that can be fatal, such as Enterococcus faecium, St...
Relationship between antihypertensive drug use and number of people with high blood pressure in FY 2018: a descriptive epidemiological study based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data
Relationship between antihypertensive drug use and number of people with high blood pressure in FY 2018: a descriptive epidemiological study based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan open data
In most countries barring Japan, antihypertensive drug use has been reported using the defined daily doses/1000 inhabitant...
Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Adherence of denosumab treatment for low bone mineral density in Japanese people living with HIV: a retrospective observational study
Long-term care issues, specifically metabolic bone disorders, are a concern for people living with human immunodeficiency ...
Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation
Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation
Methotrexate (MTX) is used to treat graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transpla...
Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration
Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration
Dexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in ...
Effect of rapid cefpodoxime disk screening for early detection of third-generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae bacteremia
Effect of rapid cefpodoxime disk screening for early detection of third-generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae bacteremia
Several methods have been reported for detecting resistance genes or phenotypic testing on the day of positive blood cultu...
Efficacy of combined use of Suvorexant and Ramelteon in preventing postoperative delirium: a retrospective comparative study
Efficacy of combined use of Suvorexant and Ramelteon in preventing postoperative delirium: a retrospective comparative study
Suvorexant and ramelteon have been presented as useful for preventing postoperative delirium. Previous studies reported on...
Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
Gastrointestinal injuries caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is a serious side effect in patients wit...
Heart failure drug classes and 30-day unplanned hospital readmission among patients with heart failure in Ethiopia
Heart failure drug classes and 30-day unplanned hospital readmission among patients with heart failure in Ethiopia
Drug therapy is a crucial aspect of heart failure management and has been shown to reduce morbidity and mortality in heart...
Trends in teicoplanin loading dose implementation from 2010 to 2019 and evaluation of safety and efficacy factors: a retrospective cohort study based on a Japanese administrative claims database
Trends in teicoplanin loading dose implementation from 2010 to 2019 and evaluation of safety and efficacy factors: a retrospective cohort study based on a Japanese administrative claims database
The loading dose of teicoplanin (TEIC) is recommended for implementation. However, there is significant discrepancy betwee...
Faculty publication trends in a Japanese national university: a diachronic document analysis
Faculty publication trends in a Japanese national university: a diachronic document analysis
We previously demonstrated that in a Japanese national university’s medical faculty, overall paper publication frequ...
Poor removal of tedizolid during continuous hemodiafiltration: experiments using an in vitro continuous hemodiafiltration model
Poor removal of tedizolid during continuous hemodiafiltration: experiments using an in vitro continuous hemodiafiltration model
Tedizolid is an oxazolidinone anti-MRSA drug with included in the National Health Insurance Drug Price List in 2018. The e...
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection
Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resist...
Evaluation of the clinical and quantitative performance of a practical HPLC-UV platform for in-hospital routine therapeutic drug monitoring of multiple drugs
Evaluation of the clinical and quantitative performance of a practical HPLC-UV platform for in-hospital routine therapeutic drug monitoring of multiple drugs
In-hospital therapeutic drug monitoring (TDM) requires a suitable quantification method for target drugs from the viewpoin...
Analysis of factors affecting pharmacists' ability to identify and solve problems
Analysis of factors affecting pharmacists' ability to identify and solve problems
Among Japanese pharmacists, there is a gap in their commitment to self-improvement and a possible gap in their ability to ...
A systematic review of sodium-glucose cotransporter 2 inhibitors and renal profiles among Japanese patients with type 2 diabetes mellitus
A systematic review of sodium-glucose cotransporter 2 inhibitors and renal profiles among Japanese patients with type 2 diabetes mellitus
We conducted a systematic review and meta-analysis to summarize the available literature and comprehensively appraise the ...
Significance of pharmacist intervention to oral antithrombotic therapy in the pharmaceutical outpatient clinic of cardiovascular internal medicine: a retrospective cohort study
Significance of pharmacist intervention to oral antithrombotic therapy in the pharmaceutical outpatient clinic of cardiovascular internal medicine: a retrospective cohort study
Optimised antithrombotic therapy requires clinical experience and an understanding of the current guidelines. This retrosp...
Differences in the growth of microorganisms depends on the type of semi-solid enteral nutritional supplements
Differences in the growth of microorganisms depends on the type of semi-solid enteral nutritional supplements
Enteral nutritional supplements are used in many medical facilities and home care, but require appropriate management beca...
Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk
Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk
Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onse...
A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide
A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide
Difficulty in taking solid medicines is a common issue particularly for the elderly because of a decline in swallowing fun...
Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
Knowledge about stem cell sources and obstacles in donation of bone marrow and peripheral blood stem cells: a cross-sectional survey from Ha’il city to track the prospects of regenerative medicine in Saudi Arabia
Promoting stem cell donation behaviors could be crucial in advancing stem cell-based treatment, research and improving pub...
Tazobactam/ceftolozane and tobramycin combination therapy in extensively drug-resistant Pseudomonas aeruginosa infections in severe burn injury: a case report
Tazobactam/ceftolozane and tobramycin combination therapy in extensively drug-resistant Pseudomonas aeruginosa infections in severe burn injury: a case report
Combination therapy with tazobactam/ceftolozane (TAZ/CTLZ) and high-dose aminoglycosides has been reported to be efficacio...
Olanzapine treatment effectively relieves breakthrough chemotherapy-induced nausea and vomiting: a real-world experience
Olanzapine treatment effectively relieves breakthrough chemotherapy-induced nausea and vomiting: a real-world experience
Olanzapine treatment prevents chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chem...
Adrenaline-resistant anaphylactic shock caused by contrast medium in a patient after risperidone overdose: a case report
Adrenaline-resistant anaphylactic shock caused by contrast medium in a patient after risperidone overdose: a case report
In Japan, the use of risperidone in combination with adrenaline is contraindicated, except in cases of anaphylaxis. Theref...
Risk factors for thromboembolism during first-line treatment of patients with unresectable advanced or recurrent colorectal cancer: a retrospective short study
Risk factors for thromboembolism during first-line treatment of patients with unresectable advanced or recurrent colorectal cancer: a retrospective short study
While cancer is a risk factor for developing thromboembolism, so is the use of molecularly targeted therapies. This study ...
Comparison of the conventional and immersing powdered crude drugs (IPCD) methods for color and extraction of quantitative indicator ingredients in the Kampo formula decoction of daiokanzoto
Comparison of the conventional and immersing powdered crude drugs (IPCD) methods for color and extraction of quantitative indicator ingredients in the Kampo formula decoction of daiokanzoto
The immersing powdered crude drugs (IPCD) method is a quick and simple method for preparing decoctions. Here, the conventi...
Skin absorption of felbinac solid nanoparticles in gel formulation containing l-menthol and carboxypolymethylene
Skin absorption of felbinac solid nanoparticles in gel formulation containing l-menthol and carboxypolymethylene
It is important to design an effective formulation to enhance the skin penetration, and nanotechnologies have been used in...
Investigation of appropriate needle length considering skin thickness with the real injection posture for insulin injections in diabetic patients
Investigation of appropriate needle length considering skin thickness with the real injection posture for insulin injections in diabetic patients
Insulin treatment is widely used not only for type 1 but also for type 2 diabetes patients. Insulin must be injected into ...
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