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New frontiers in sulfur and selenium chemical biology
New frontiers in sulfur and selenium chemical biology
Kate S. Carroll is a Professor in the Department of Chemistry at the Herbert Werthheim UF Scripps Institute for Biomedical...
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
Metabolomics-guided utilization of beneficial microbes for climate-resilient crops
In the rhizosphere, plants and microbes communicate chemically, especially under environmental stress. Over millions of ye...
Versatile roles of cysteine persulfides in tumor biology
Versatile roles of cysteine persulfides in tumor biology
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in ...
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
D-Amino acid oxidase-derived chemogenetic oxidative stress: Unraveling the multi-omic responses to in vivo redox stress
The dynamic equilibrium between the generation of reactive oxygen species (ROS) and the antioxidative defense mechanisms w...
A new era of cysteine proteomics – Technological advances in thiol biology
A new era of cysteine proteomics – Technological advances in thiol biology
Protein cysteines garner interest for their distinct chemical properties, rendering them amenable to a diverse range of mo...
Biochemistry of the hypoxia-inducible factor hydroxylases
Biochemistry of the hypoxia-inducible factor hydroxylases
KeywordsHypoxia-inducible factor (HIF)HIF prolyl-hydroxylases (PHDs/EGLNs)JmjC demethylasesFactor inhibiting HIF (FIH)Aspa...
Lumos maxima – How robust fluorophores resist photobleaching?
Lumos maxima – How robust fluorophores resist photobleaching?
Advanced fluorescence imaging technology, jointly enabled by microscopes and cutting-edge fluorescent labels, promises to ...
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Recent advances in ratiometric fluorescence imaging of enzyme activity in vivo
Functional imaging of enzyme activity in living systems provides valuable insights into biological processes and disease s...
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Advancing mass spectrometry–based glycoproteomic software tools for comprehensive site-specific glycoproteome analysis
Protein glycosylation, as one of the most widespread and complex post-translational modifications (PTMs), plays an importa...
Site-specific protein labeling strategies for super-resolution microscopy
Site-specific protein labeling strategies for super-resolution microscopy
KeywordsSite-specific labelingSuper-resolution microscopyPeptide-tagPeptide-PAINTUnnatural amino acidNon-canonical amino a...
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Sortase-mediated labeling: Expanding frontiers in site-specific protein functionalization opens new research avenues
Many modern pursuits of molecular biology and biochemistry are built on precise and selective protein labeling techniques....
Fluorogenic polymethine dyes by intramolecular cyclization
Fluorogenic polymethine dyes by intramolecular cyclization
KeywordsFluorogenicityCarbocyaninesPolymethine dyesTurn-on probesIntramolecular cyclizationsSelf-labeling protein tagsSmal...
Chemical toolbox to interrogate Heparanase-1 activity
Chemical toolbox to interrogate Heparanase-1 activity
Heparanase-1 (HPSE-1), an endo-β-d-glucuronidase, is the only known enzyme that cleaves heparan sulfate (HS) [1,2]. The HP...
Chemical biology tools to probe bacterial glycans
Chemical biology tools to probe bacterial glycans
Bacterial cells are covered by a complex carbohydrate coat of armor that allows bacteria to thrive in a range of environme...
Advances in understanding and exploiting Siglec–glycan interactions
Advances in understanding and exploiting Siglec–glycan interactions
Siglecssialic-acid-binding immunoglobulin-type lectinsSAMPself-associated molecular patternITIMimmunoreceptor-tyrosine-bas...
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studies
Heparan sulfate (HS) is an important class of polysaccharides that plays roles in a wide range of biological events, inclu...
Small-molecule tools for YEATS domain proteins
Small-molecule tools for YEATS domain proteins
Transcriptional co-regulatory proteins act on and through chromatin to control RNA polymerase activity [1]. These proteins...
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Post-translational modifications (PTMs) of proteins, such as methylation, phosphorylation, and glycosylation, have a profo...
Editorial overview: Glycobiology (2023)
Editorial overview: Glycobiology (2023)
Matthew Macauley is an associate professor within the Department of Chemistry at the University of Alberta and currently h...
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Enzymes mediate a great diversity of reactions that enable a wide range of cellular processes. The activities of enzymes w...
Nutritional metabolomics: Recent developments and future needs
Nutritional metabolomics: Recent developments and future needs
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Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epide...
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-translational modification known as ADP-rib...
Global approaches for protein thiol redox state detection
Global approaches for protein thiol redox state detection
Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence, cysteine often has important ...
Editorial overview: Imaging metal ions in biological systems
Editorial overview: Imaging metal ions in biological systems
Daniela Buccella. Dr. Buccella is a professor in the Department of Chemistry at New York University. She obtained her bach...
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Within the past decade, the role of cysteine oxidation in organismal stress response has been established as a fundamental...
Recent chemical synthesis of plant polysaccharides
Recent chemical synthesis of plant polysaccharides
As the essential and most abundant biomolecules, carbohydrates are involved in the numerous biological processes with a va...
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Cong Liu received his Ph.D. in Biochemistry from the Peking University, followed by a postdoc training at UCLA. He started...
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Zinc (Zn2+) is an important component of various proteins and plays important roles in many biological processes. It is bu...
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
Curative oncologic surgery successfully removes all cancerous tissues from the body and is the most effective treatment mo...
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