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Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tub...
O-GlcNAcylation: the sweet side of epigenetics
O-GlcNAcylation: the sweet side of epigenetics
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylati...
Role of sex in immune response and epigenetic mechanisms
Role of sex in immune response and epigenetic mechanisms
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex ...
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate...
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-a...
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) i...
Chromatin balances cell redox and energy homeostasis
Chromatin balances cell redox and energy homeostasis
Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessi...
Expression analysis suggests that DNMT3L is required for oocyte de novo DNA methylation only in Muridae and Cricetidae rodents
Expression analysis suggests that DNMT3L is required for oocyte de novo DNA methylation only in Muridae and Cricetidae rodents
During early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between som...
Estimating genome-wide DNA methylation heterogeneity with methylation patterns
Estimating genome-wide DNA methylation heterogeneity with methylation patterns
In a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. T...
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neurosc...
EphrinA5 regulates cell motility by modulating Snhg15/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter
EphrinA5 regulates cell motility by modulating Snhg15/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter
Cell–cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestr...
Development of super-specific epigenome editing by targeted allele-specific DNA methylation
Development of super-specific epigenome editing by targeted allele-specific DNA methylation
Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dC...
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae
Classical studies on position effect variegation in Drosophila have demonstrated the existence of bi-modal Active/Silent s...
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA...
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used...
Knockout tales: the versatile roles of histone H3.3 in development and disease
Knockout tales: the versatile roles of histone H3.3 in development and disease
Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutate...
Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
Blood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate wit...
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to N...
Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data
Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data
Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood....
Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (c...
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emergin...
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. ...
Alterations in the hepatocyte epigenetic landscape in steatosis
Alterations in the hepatocyte epigenetic landscape in steatosis
Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes...
Etiology of super-enhancer reprogramming and activation in cancer
Etiology of super-enhancer reprogramming and activation in cancer
Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes critical for cell identity. Tumori...
The role of Dmnt1 during spermatogenesis of the insect Oncopeltus fasciatus
The role of Dmnt1 during spermatogenesis of the insect Oncopeltus fasciatus
The function of DNA methyltransferase genes of insects is a puzzle, because an association between gene expression and met...
Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics
Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics
Our understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last f...
Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data
Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data
High-throughput sequencing (HTS) offers unprecedented opportunities for the discovery of causative gene variants in multip...
PARP-dependent and NAT10-independent acetylation of N4-cytidine in RNA appears in UV-damaged chromatin
PARP-dependent and NAT10-independent acetylation of N4-cytidine in RNA appears in UV-damaged chromatin
RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the ...
Assignment of the somatic A/B compartments to chromatin domains in giant transcriptionally active lampbrush chromosomes
Assignment of the somatic A/B compartments to chromatin domains in giant transcriptionally active lampbrush chromosomes
The three-dimensional configuration of the eukaryotic genome is an emerging area of research. Chromosome conformation capt...
Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites
Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites
Gene expression in malaria parasites is subject to various layers of regulation, including histone post-translational modi...
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