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Pervasive environmental chemicals impair oligodendrocyte development
Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as t...
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into bio...
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germin...
A precision functional atlas of personalized network topography and probabilities
A precision functional atlas of personalized network topography and probabilities
Although the general location of functional neural networks is similar across individuals, there is vast person-to-person ...
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Microglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain sample...
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peri...
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis
The generation of new myelin-forming oligodendrocytes in the adult central nervous system is critical for cognitive functi...
Retraction Note: Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression
Takushi ShimomuraPresent address: Division of Biophysics and Neurobiology, Department of Molecular Physiology, National In...
In conversation with Ukpong Eyo
In conversation with Ukpong Eyo
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
In conversation with Kelsey Martin
In conversation with Kelsey Martin
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the f...
Updating the striatal–pallidal wiring diagram
Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning and execution of flexible behav...
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairmen...
Myelin and Alzheimer’s disease
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
How we promote data sharing
In 2022, we began a pilot to facilitate data sharing for manuscripts submitted to Nature Neuroscience. Here, we analyze it...
How human brains differ
Large datasets have been generated to characterize gene expression and cell types in brain samples from many individuals, ...
Octopuses untethered
Electrophysiological studies of octopus neural activity have been hampered by the inability to anchor recording equipment ...
Sniffing for functional SNVs
Genome-wide association studies (GWAS) have identified thousands of single-nucleotide variants (SNVs) that are correlated ...
A farewell to 2023
As 2023 draws to a close, the Nature Neuroscience editors reflect on the year in neuroscience and in our pages.
Pregnant brains in parent mode
Parenthood requires substantial behavioral adaptations to ensure the well-being of offspring. Such behavior relies on vari...
This neuroprosthesis was made for walking
People with advanced Parkinson’s disease (PD) often present with locomotor deficits that do not respond to current therapi...
Author Correction: Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Neuroscience Institute, NYU Grossman School of Medicine, New York City, NY, USAPaul W. Frazel, Theodore Fisher, Anne March...
Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis
Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis
We discovered expression of SYNGAP1, which encodes the ‘synaptic’ protein SYNGAP1, within human cortical proge...
Skull bone marrow channels as immune gateways to the central nervous system
Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous c...
A brainstem circuit for phonation and volume control in mice
A brainstem circuit for phonation and volume control in mice
Mammalian vocalizations are critical for communication and are produced through the process of phonation, in which expirat...
A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period ...
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
It is generally thought that under basal conditions, neurons produce ATP mainly through mitochondrial oxidative phosphoryl...
Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase
Lysosome regulation of microglia in Alzheimer’s disease via TFEB–vacuolar ATPase
We show that genetic disruption of TFEB- and vacuolar ATPase-mediated lysosomal signaling leads to increased tau pathology...
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Whole-brain genome editing to correct single-base mutations and reduce or reverse behavioral changes in animal models of a...
Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
These authors contributed equally: Zhen Zhao, Abhay P Sagare, Qingyi Ma.Zilkha Neurogenetic Institute and Department of Ph...
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulat...
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