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A revised view of the role of CaMKII in learning and memory
A revised view of the role of CaMKII in learning and memory
The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in m...
A top-down slow breathing circuit that alleviates negative affect in mice
A top-down slow breathing circuit that alleviates negative affect in mice
Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem r...
Converging cortical axes
Converging cortical axes
The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular speci...
Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, includi...
The cell-type underpinnings of the human functional cortical connectome
The cell-type underpinnings of the human functional cortical connectome
The functional properties of the human brain arise, in part, from the vast assortment of cell types that pattern the cereb...
The BRAIN initiative: a pioneering program on the precipice
The BRAIN initiative: a pioneering program on the precipice
Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop...
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram
A long-standing goal in neuroscience is to understand how a circuit’s form influences its function. Here, we reconst...
Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex
Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex
Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome. MeCP2 is thought to regulate gene transcription by ...
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cere...
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cere...
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we addre...
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we addre...
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental...
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental...
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neu...
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neu...
Nested compressed co-representations of multiple sequential experiences during sleep
Nested compressed co-representations of multiple sequential experiences during sleep
Animals encounter and remember multiple experiences daily. During sleep, hippocampal neuronal ensembles replay past experi...
Nested compressed co-representations of multiple sequential experiences during sleep
Nested compressed co-representations of multiple sequential experiences during sleep
Animals encounter and remember multiple experiences daily. During sleep, hippocampal neuronal ensembles replay past experi...
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual t...
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual t...
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Authors and AffiliationsSchool of Life Sciences, University of Sussex, Falmer, Brighton, UKIan J. Russell, P. Kevin Legan,...
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Authors and AffiliationsSchool of Life Sciences, University of Sussex, Falmer, Brighton, UKIan J. Russell, P. Kevin Legan,...
Explaining dopamine through prediction errors and beyond
Explaining dopamine through prediction errors and beyond
The most influential account of phasic dopamine holds that it reports reward prediction errors (RPEs). The RPE-based inter...
Explaining dopamine through prediction errors and beyond
Explaining dopamine through prediction errors and beyond
The most influential account of phasic dopamine holds that it reports reward prediction errors (RPEs). The RPE-based inter...
Pervasive environmental chemicals impair oligodendrocyte development
Pervasive environmental chemicals impair oligodendrocyte development
Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as t...
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into bio...
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germin...
A precision functional atlas of personalized network topography and probabilities
A precision functional atlas of personalized network topography and probabilities
Although the general location of functional neural networks is similar across individuals, there is vast person-to-person ...
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
Microglia are central players in Alzheimer’s disease pathology but analyzing microglial states in human brain sample...
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peri...
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