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A flexible hippocampal population code for experience relative to reward
A flexible hippocampal population code for experience relative to reward
To reinforce rewarding behaviors, events leading up to and following rewards must be remembered. Hippocampal place cell ac...
Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions...
The brain works at more than 10 bits per second
A recent article makes a claim with far-reaching implications for neuroscience, technology, and society: that the human br...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer̵...
Challenges of the inconsistent neurorights framework in Latin America
The integration of neurotechnology into society has prompted urgent discussions on neurorights (new lists of human rights ...
Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging
Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging
The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in reg...
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment
Interictal epileptiform discharges (IEDs) are expressed in epileptic networks and disrupt cognitive functions. It is uncle...
Large-scale high-density brain-wide neural recording in nonhuman primates
Large-scale high-density brain-wide neural recording in nonhuman primates
High-density silicon probes have transformed neuroscience by enabling large-scale neural recordings at single-cell resolut...
A revised view of the role of CaMKII in learning and memory
A revised view of the role of CaMKII in learning and memory
The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in m...
A top-down slow breathing circuit that alleviates negative affect in mice
A top-down slow breathing circuit that alleviates negative affect in mice
Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem r...
Converging cortical axes
Converging cortical axes
The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular speci...
Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, includi...
The cell-type underpinnings of the human functional cortical connectome
The cell-type underpinnings of the human functional cortical connectome
The functional properties of the human brain arise, in part, from the vast assortment of cell types that pattern the cereb...
The BRAIN initiative: a pioneering program on the precipice
The BRAIN initiative: a pioneering program on the precipice
Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop...
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram
Predicting modular functions and neural coding of behavior from a synaptic wiring diagram
A long-standing goal in neuroscience is to understand how a circuit’s form influences its function. Here, we reconst...
Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex
Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex
Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome. MeCP2 is thought to regulate gene transcription by ...
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cere...
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cere...
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we addre...
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior
The most robust and reliable signatures of brain states are enriched in rhythms between 0.1 and 20 Hz. Here we addre...
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental...
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has been limited by a lack of experimental...
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neu...
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Perineuronal nets (PNNs) are densely packed extracellular matrices that cover the cell body of fast-spiking inhibitory neu...
Nested compressed co-representations of multiple sequential experiences during sleep
Nested compressed co-representations of multiple sequential experiences during sleep
Animals encounter and remember multiple experiences daily. During sleep, hippocampal neuronal ensembles replay past experi...
Nested compressed co-representations of multiple sequential experiences during sleep
Nested compressed co-representations of multiple sequential experiences during sleep
Animals encounter and remember multiple experiences daily. During sleep, hippocampal neuronal ensembles replay past experi...
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual t...
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice
Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual t...
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Authors and AffiliationsSchool of Life Sciences, University of Sussex, Falmer, Brighton, UKIan J. Russell, P. Kevin Legan,...
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Author Correction: Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Authors and AffiliationsSchool of Life Sciences, University of Sussex, Falmer, Brighton, UKIan J. Russell, P. Kevin Legan,...
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