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Effects of glucagon-like peptide-1 receptor agonists on liver-related and cardiovascular mortality in patients with type 2 diabetes
Effects of glucagon-like peptide-1 receptor agonists on liver-related and cardiovascular mortality in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) tend to have nonalcoholic fatty liver disease (NAFLD) with poorer prognosis. We perfor...
Benefits and challenges experienced by participants on long-term methadone maintenance treatment in China: a qualitative study
Benefits and challenges experienced by participants on long-term methadone maintenance treatment in China: a qualitative study
Methadone maintenance treatment (MMT) has been implemented in China for nearly two decades, with a significant decrease in...
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previ...
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
We aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD). Summa...
Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis
Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with glioma: a meta-analysis
Many studies have explored the prognostic role of the lymphocyte-to-monocyte ratio (LMR) in patients with glioma, but the ...
Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019
Performance of a safe and dignified burial intervention during an Ebola epidemic in the eastern Democratic Republic of the Congo, 2018–2019
A protracted Ebola Virus Disease (EVD) epidemic in the eastern Ituri, North and South Kivu provinces of the Democratic Rep...
Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
This study aimed to investigate the neuroanatomical subtypes among early-onset schizophrenia (EOS) patients by exploring t...
Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
The results of clinical trials should be completely and rapidly reported during public health emergencies such as COVID-19...
Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers
Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers
Healthcare workers’ (HCW) well-being has a direct effect on patient care. However, little is known about the prevale...
Radiomics in precision oncology: hype or ludum mutante
Radiomics in precision oncology: hype or ludum mutante
Precision oncology has emerged as the next frontier of therapeutic strategies in the treatment of human cancers. The idea ...
Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Clinical efficacy of sodium bicarbonate in treating pediatric metabolic acidosis with varying level of acid–base balance parameters: a real-world study
Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controv...
Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021
Representativeness in health research studies: an audit of Greater Manchester Clinical Research Network studies between 2016 and 2021
There are increasing concerns that participants in health research in the UK are not representative of the UK population, ...
Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
Increasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic...
A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas
A pilot study of multi-antigen stimulated cell therapy-I plus camrelizumab and apatinib in patients with advanced bone and soft-tissue sarcomas
Cell-based  immunotherapy shows the therapeutic potential in sarcomas, in addition to angiogenesis-targeted tyros...
Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis
Prognostic value of circulating tumor DNA in operable non-small cell lung cancer: a systematic review and reconstructed individual patient-data based meta-analysis
This reconstructed individual patient data (IPD)-based meta-analysis is aimed to summarize the current findings and compre...
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression
Endometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside ...
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
Sex difference exists in the prevalence of dementia and cognitive decline. The impacts of sex-specific reproductive risk f...
The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study
The impact of the new acute respiratory distress syndrome (ARDS) criteria on Berlin criteria ARDS patients: a multicenter cohort study
The European Society of Intensive Care Medicine (ESICM) recently recommended changes to the criteria of acute respiratory ...
Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women
Are breast cancer patients with suboptimal adherence to cardiovascular treatment more likely to discontinue adjuvant endocrine therapy? Competing risk survival analysis in a nationwide cohort of postmenopausal women
High rates of discontinuation undermine the effectiveness of adjuvant endocrine therapy (AET) among hormone-receptive brea...
Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
Why diversity among participants in clinical studies is not always preferable: the case for small, exploratory studies
While we welcome the increasing number of initiatives to diminish unbalanced diversity in clinical trials, we would like t...
Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury
Mood, Activity Participation, and Leisure Engagement Satisfaction (MAPLES): results from a randomised controlled pilot feasibility trial for low mood in acquired brain injury
Acquired brain injury (ABI) is linked to increased depression risk. Existing therapies for depression in ABI (e.g., cognit...
The association between cognitive ability and opioid prescribing in vulnerable older adults with chronic pain in ambulatory care: a secondary data analysis using the Medical Expenditure Panel Survey
The association between cognitive ability and opioid prescribing in vulnerable older adults with chronic pain in ambulatory care: a secondary data analysis using the Medical Expenditure Panel Survey
Vulnerable older adults living with Alzheimer’s disease or Alzheimer’s disease and related dementia (AD/ADRD) ...
Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies
Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies
There is growing evidence that substituting animal-based with plant-based foods is associated with a lower risk of cardiov...
Comparative effectiveness of multiple different treatment regimens for nonalcoholic fatty liver disease with type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis of randomised controlled trials
Comparative effectiveness of multiple different treatment regimens for nonalcoholic fatty liver disease with type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis of randomised controlled trials
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are closely related and mutually contribute t...
Associations between types and sources of dietary carbohydrates and liver fat: a UK Biobank study
Associations between types and sources of dietary carbohydrates and liver fat: a UK Biobank study
Excess energy intake can lead to metabolic dysfunction-associated steatotic liver disease (MASLD), but the relationship be...
Trends in the ability of socioeconomic position to predict individual body mass index: an analysis of repeated cross-sectional data, 1991–2019
Trends in the ability of socioeconomic position to predict individual body mass index: an analysis of repeated cross-sectional data, 1991–2019
The widening of group-level socioeconomic differences in body mass index (BMI) has received considerable research attentio...
Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort
Circulating oxysterols and prognosis among women with a breast cancer diagnosis: results from the MARIE patient cohort
Breast cancer is the most commonly diagnosed cancer in women worldwide, and underlying mechanistic pathways associated wit...
Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study
Is metabolic-healthy obesity associated with risk of dementia? An age-stratified analysis of the Whitehall II cohort study
Metabolically healthy obesity is hypothesized to be a benign condition but whether this is the case for dementia remains d...
Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
‘S Heeren Loo, Amersfoort, The NetherlandsAnnelieke R. Müller & Agnies M. van EeghenEmma Center for Personalized Medic...
A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy
A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy
Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disapp...
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