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Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Abdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal...
The Role of Sleep in Cardiovascular Disease
The Role of Sleep in Cardiovascular Disease
Sleep is an important component of cardiovascular (CV) health. This review summarizes the complex relationship between sle...
Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease
Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease
Despite recent advances, coronary artery disease remains one of the leading causes of mortality worldwide. Noninvasive ima...
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Globally, the prevalence of metabolic disorders is rising. Elevated low-density lipoprotein (LDL) cholesterol is a hallmar...
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
This review investigates the relationship between myocardial bridges (MBs), intimal thickening in coronary arteries, and A...
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Our work is to establish more distinct association between specific stress and vascular smooth muscle cells (VSMCs) phenot...
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early athero...
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by lifelong elevation of severely elevated p...
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are gaining importance due to their effects on cardiovascular paramet...
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Vascular dementia (VaD) is the second most prevalent type of dementia after Alzheimer's disease.Hypercholesterolemia m...
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
This review seeks to provide important information on each of the major domains of social determinants of health (SDOH) in...
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Current guidelines for primary and secondary prevention of cardiovascular events in adults up to age 75 years are...
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
To highlight that body fat depletion (the Yin paradigm) with glucose-lowering treatments (the Yang paradigm) are associate...
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
In this review, we discuss contemporary and emerging approaches for risk stratification and management of excess adiposity...
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Cardiometabolic diseases, which include obesity, type 2 diabetes, and cardiovascular diseases, constitute a worldwide heal...
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
To discuss the history of cardiovascular outcomes trials of cholesteryl ester transfer protein (CETP) inhibitors and to de...
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological health encompasses a constellation of negative and positive factors—i.e., psychosocial stress, depress...
How Will Our Practice Change After the CLEAR Outcomes Trial?
How Will Our Practice Change After the CLEAR Outcomes Trial?
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-...
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of premature death. Lipid disorders, particularly elevat...
Lipoprotein(a): from Causality to Treatment
Lipoprotein(a): from Causality to Treatment
This paper reviews the evidence why lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disease and how high...
European Lipid Guidelines and Cardiovascular Risk Estimation: Current Status and Future Challenges
European Lipid Guidelines and Cardiovascular Risk Estimation: Current Status and Future Challenges
Genetic, experimental, epidemiologic, and clinical data support the causal role of elevated levels of low-density lipoprot...
The Role of Genetics in Advancing Cardiometabolic Drug Development
The Role of Genetics in Advancing Cardiometabolic Drug Development
The objective of this review is to explore the role of genetics in cardiometabolic drug development. The declining costs o...
Gene Editing for the Treatment of Hypercholesterolemia
Gene Editing for the Treatment of Hypercholesterolemia
Here, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can low...
Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment
Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment
Lipoprotein(a) is an important causal risk factor for cardiovascular disease but currently no available medication effecti...
Implications of Bias in Artificial Intelligence: Considerations for Cardiovascular Imaging
Implications of Bias in Artificial Intelligence: Considerations for Cardiovascular Imaging
Bias in artificial intelligence (AI) models can result in unintended consequences. In cardiovascular imaging, biased AI mo...
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular disease (CVD). This revie...
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Heart failure (HF) is one of the main causes of cardiovascular mortality in the western world. Despite great advances in t...
What Causes Premature Coronary Artery Disease?
What Causes Premature Coronary Artery Disease?
This review provides an overview of genetic and non-genetic causes of premature coronary artery disease (pCAD). pCAD refer...
Sex Differences in Cardiac Transplantation
Sex Differences in Cardiac Transplantation
The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT). ...
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
The UK National Health Service (NHS) has recently announced a Newborn Genomes Programme (NGP) to identify infants with tre...
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