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Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
To highlight that body fat depletion (the Yin paradigm) with glucose-lowering treatments (the Yang paradigm) are associate...
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
In this review, we discuss contemporary and emerging approaches for risk stratification and management of excess adiposity...
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Cardiometabolic diseases, which include obesity, type 2 diabetes, and cardiovascular diseases, constitute a worldwide heal...
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
To discuss the history of cardiovascular outcomes trials of cholesteryl ester transfer protein (CETP) inhibitors and to de...
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan
Psychological health encompasses a constellation of negative and positive factors—i.e., psychosocial stress, depress...
How Will Our Practice Change After the CLEAR Outcomes Trial?
How Will Our Practice Change After the CLEAR Outcomes Trial?
Bempedoic acid is a novel therapeutic agent that is designed to reduce levels of low-density lipoprotein cholesterol (LDL-...
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Whether and Why Do We Need a Vaccine Against Atherosclerosis? Can We Expect It Anytime Soon?
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of premature death. Lipid disorders, particularly elevat...
Lipoprotein(a): from Causality to Treatment
Lipoprotein(a): from Causality to Treatment
This paper reviews the evidence why lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disease and how high...
European Lipid Guidelines and Cardiovascular Risk Estimation: Current Status and Future Challenges
European Lipid Guidelines and Cardiovascular Risk Estimation: Current Status and Future Challenges
Genetic, experimental, epidemiologic, and clinical data support the causal role of elevated levels of low-density lipoprot...
The Role of Genetics in Advancing Cardiometabolic Drug Development
The Role of Genetics in Advancing Cardiometabolic Drug Development
The objective of this review is to explore the role of genetics in cardiometabolic drug development. The declining costs o...
Gene Editing for the Treatment of Hypercholesterolemia
Gene Editing for the Treatment of Hypercholesterolemia
Here, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can low...
Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment
Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment
Lipoprotein(a) is an important causal risk factor for cardiovascular disease but currently no available medication effecti...
Implications of Bias in Artificial Intelligence: Considerations for Cardiovascular Imaging
Implications of Bias in Artificial Intelligence: Considerations for Cardiovascular Imaging
Bias in artificial intelligence (AI) models can result in unintended consequences. In cardiovascular imaging, biased AI mo...
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Increased Cardiovascular Risk in Young Patients with CKD and the Role of Lipid-Lowering Therapy
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular disease (CVD). This revie...
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Cardiovascular Effects of Stimulators of Soluble Guanylate Cyclase Administration: A Meta-analysis of Randomized Controlled Trials
Heart failure (HF) is one of the main causes of cardiovascular mortality in the western world. Despite great advances in t...
What Causes Premature Coronary Artery Disease?
What Causes Premature Coronary Artery Disease?
This review provides an overview of genetic and non-genetic causes of premature coronary artery disease (pCAD). pCAD refer...
Sex Differences in Cardiac Transplantation
Sex Differences in Cardiac Transplantation
The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT). ...
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
Should Familial Hypercholesterolaemia Be Included in the UK Newborn Whole Genome Sequencing Programme?
The UK National Health Service (NHS) has recently announced a Newborn Genomes Programme (NGP) to identify infants with tre...
HDL as a Treatment Target: Should We Abandon This Idea?
HDL as a Treatment Target: Should We Abandon This Idea?
High-density lipoproteins (HDL) have long been regarded as an antiatherogenic lipoprotein species by virtue of their role ...
Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease
Polycystic Ovarian Syndrome: a Risk Factor for Cardiovascular Disease
Characterize the risk of cardiovascular disease (CVD) in individuals with polycystic ovarian syndrome (PCOS). Review the p...
Polysocial Risk Scores: Implications for Cardiovascular Disease Risk Assessment and Management
Polysocial Risk Scores: Implications for Cardiovascular Disease Risk Assessment and Management
To review current evidence, discuss key knowledge gaps and identify opportunities for development, validation and applicat...
Heart Failure Treatment in 2023: Is There a Place for Lipid Lowering Therapy?
Heart Failure Treatment in 2023: Is There a Place for Lipid Lowering Therapy?
An evidence for lipid lowering therapy in heart failure is briefly summarized in this review. Heart failure therapy is bas...
Gene Regulatory Networks in Coronary Artery Disease
Gene Regulatory Networks in Coronary Artery Disease
Coronary artery disease is a complex disorder and the leading cause of mortality worldwide. As technologies for the genera...
Caregiver Influences on Eating Behaviors in Children: An Opportunity for Preventing Obesity
Caregiver Influences on Eating Behaviors in Children: An Opportunity for Preventing Obesity
This review seeks to define caregiver practices that impact childhood eating behaviors and identify ways to utilize these ...
Natural Sirtuin1 Activators and Atherosclerosis: an Overview
Natural Sirtuin1 Activators and Atherosclerosis: an Overview
The purpose of this review is to summarize the most recent findings investigating the impact of several natural sirtuin (S...
Emerging Preventive Strategies in Chronic Kidney Disease: Recent Evidence and Gaps in Knowledge
Emerging Preventive Strategies in Chronic Kidney Disease: Recent Evidence and Gaps in Knowledge
Chronic kidney disease (CKD) is increasingly prevalent worldwide and is associated with increased cardiovascular risk. New...
Machine Learning in Cardiovascular Risk Prediction and Precision Preventive Approaches
Machine Learning in Cardiovascular Risk Prediction and Precision Preventive Approaches
In this review, we sought to provide an overview of ML and focus on the contemporary applications of ML in cardiovascular ...
Lipid Lowering Drugs in Acute Coronary Syndromes (ACS)
Lipid Lowering Drugs in Acute Coronary Syndromes (ACS)
The purpose of this review is to critically discuss whether more aggressive lipid-lowering strategies are needed in patien...
Obesity and Dyslipidemia
Obesity and Dyslipidemia
This article sumarizes pathopysiological consequencies between obesity and dyslipidemia and aims to bring some practical a...
Highlights of Cardiovascular Disease Prevention Studies Presented at the 2023 European Society of Cardiology Congress
Highlights of Cardiovascular Disease Prevention Studies Presented at the 2023 European Society of Cardiology Congress
To summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2023 European Socie...
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