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The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
The Emerging Potential of Apolipoprotein C-III Inhibition for ASCVD Prevention: A State-of-the-Art Review
Multiple agents are being developed that inhibit apolipoprotein (apo) C-III. This state-of-the-art review examines their p...
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
Erosion of the Atheroma: Wicked T Cells at the Culprit Site
There is a growing recognition of plaque erosion as a cause of acute coronary syndrome. This review aims to examine the po...
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statin-Associated Muscle Symptoms: Identification and Recommendations for Management
Statins are first-line pharmacotherapy for the treatment of elevated low-density lipoprotein cholesterol and are generally...
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Dyslipidemia is a casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more e...
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
Bridging the Gap: How Accounting for Social Determinants of Health Can Improve Digital Health Equity in Cardiovascular Medicine
In this review, we discuss the importance of digital health equity and how social determinants of health (and intersection...
Lp(a): A Rapidly Evolving Therapeutic Landscape
Lp(a): A Rapidly Evolving Therapeutic Landscape
Elevated lipoprotein(a) (Lp[a]) is a genetically determined cardiovascular risk factor, causally linked to both atheroscle...
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion
RNA-binding proteins (RBPs) have emerged as crucial regulators of post-transcriptional processes, influencing the fate of ...
Statin Therapy for Primary and Secondary Prevention in Older Adults
Statin Therapy for Primary and Secondary Prevention in Older Adults
Although statin therapy is well established to prevent atherosclerotic vascular disease (ASCVD) events in adults 40 to 75 ...
Ezetimibe: Integrating Established Use with New Evidence - A Comprehensive Review
Ezetimibe: Integrating Established Use with New Evidence - A Comprehensive Review
To consolidate key information on the efficacy and safety of ezetimibe, with a focus on the latest evidence. While ezetimi...
IL-6 and Cardiovascular Risk: A Narrative Review
IL-6 and Cardiovascular Risk: A Narrative Review
The objective of this narrative review is to summarize data from recently published prospective observational studies that...
Impact of Climate Change on Cardiovascular Health
Impact of Climate Change on Cardiovascular Health
Climate change is profoundly impacting cardiovascular disease through rising temperatures, more extreme weather events, an...
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
Pericoronary Fat Attenuation: Diagnosis and Clinical Implications
The purpose of this review is to evaluate the current state of knowledge regarding the technical challenges associated wit...
PCSK9 Monoclonal Antibodies Have Come a Long Way
PCSK9 Monoclonal Antibodies Have Come a Long Way
This review examines the pivotal role of monoclonal antibodies against PCSK9 in lipid-lowering therapy, emphasizing their ...
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
Targeting Inflammatory Pathways in Atherosclerosis: Exploring New Opportunities for Treatment
This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic ant...
Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights
Abdominal aortic aneurysm refers to a serious medical condition that can cause the irreversible expansion of the abdominal...
The Role of Sleep in Cardiovascular Disease
The Role of Sleep in Cardiovascular Disease
Sleep is an important component of cardiovascular (CV) health. This review summarizes the complex relationship between sle...
Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease
Noninvasive Atherosclerotic Phenotyping: The Next Frontier into Understanding the Pathobiology of Coronary Artery Disease
Despite recent advances, coronary artery disease remains one of the leading causes of mortality worldwide. Noninvasive ima...
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Therapeutic Monoclonal Antibodies for Metabolic Disorders: Major Advancements and Future Perspectives
Globally, the prevalence of metabolic disorders is rising. Elevated low-density lipoprotein (LDL) cholesterol is a hallmar...
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
Myocardial Bridge and Atherosclerosis, an Intimal Relationship
This review investigates the relationship between myocardial bridges (MBs), intimal thickening in coronary arteries, and A...
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Stress, Vascular Smooth Muscle Cell Phenotype and Atherosclerosis: Novel Insight into Smooth Muscle Cell Phenotypic Transition in Atherosclerosis
Our work is to establish more distinct association between specific stress and vascular smooth muscle cells (VSMCs) phenot...
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
Unraveling the miRNA Puzzle in Atherosclerosis: Revolutionizing Diagnosis, Prognosis, and Therapeutic Approaches
To eradicate atherosclerotic diseases, novel biomarkers, and future therapy targets must reveal the burden of early athero...
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
The Role of Reverse Cascade Screening in Children with Familial Hypercholesterolemia: A Literature Review and Analysis
Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by lifelong elevation of severely elevated p...
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
GLP-1 Receptor Agonists and Cardiovascular Disease: What Do Clinicians Need to Know?
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are gaining importance due to their effects on cardiovascular paramet...
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Hypercholesterolemia and the Increased Risk of Vascular Dementia: a Cholesterol Perspective
Vascular dementia (VaD) is the second most prevalent type of dementia after Alzheimer's disease.Hypercholesterolemia m...
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
The Role of Social Determinants of Health in Atherosclerotic Cardiovascular Disease
This review seeks to provide important information on each of the major domains of social determinants of health (SDOH) in...
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Cholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Current guidelines for primary and secondary prevention of cardiovascular events in adults up to age 75 years are...
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
To highlight that body fat depletion (the Yin paradigm) with glucose-lowering treatments (the Yang paradigm) are associate...
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease
In this review, we discuss contemporary and emerging approaches for risk stratification and management of excess adiposity...
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Targeting the Gut Microbiome to Treat Cardiometabolic Disease
Cardiometabolic diseases, which include obesity, type 2 diabetes, and cardiovascular diseases, constitute a worldwide heal...
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments
To discuss the history of cardiovascular outcomes trials of cholesteryl ester transfer protein (CETP) inhibitors and to de...
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