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Backbone distortions in lactam‐bridged helical peptides
Side-chain-to-side-chain cyclization is frequently used to stabilize the α-helical conformation of short peptides. I...
Journal Of Peptide Science
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Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β...
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Laminaria japonica cyclic peptides exert anti‐colorectal carcinoma effects through apoptosis induction in vitro and in vivo
Laminaria japonica is consumed as a health food and used as a traditional medicine because of its biochemical and pharmaco...
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Targeted β‐catenin ubiquitination and degradation by multifunctional stapled peptides
Aberrant activation of the Wnt signaling pathway has been identified in numerous types of cancer. One common feature of on...
Journal Of Peptide Science
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Current synthetic chemistry towards cyclic antimicrobial peptides
Antimicrobial peptides (AMPs) have great potentials for developing novel antibiotics against multi-drug resistant (MDR) ba...
Journal Of Peptide Science
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Substrate plasticity of dehydratase SpaKC from the biosynthesis of thiosparsoamide
Thioamitides are a group of ribosomally synthesized and post-translationally modified peptides that possess diverse bioact...
Journal Of Peptide Science
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Heterochiral tetrapeptide self‐assembly into hydrogel biomaterials for hydrolase mimicry
Self-assembling short peptides have attracted great interest as enzyme mimics, especially if the catalytic activity reside...
Journal Of Peptide Science
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Reversible crosslinked assembly of a trimeric coiled‐coil peptide into a three‐dimensional matrix for cell encapsulation and release
Mimicking the extracellular matrix (ECM) continues to be a goal in the field of regenerative medicine. Herein, we report a...
Journal Of Peptide Science
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Interactions of two enantiomers of a designer antimicrobial peptide with structural components of the bacterial cell envelope
Antimicrobial peptides (AMPs) have great potential in treating multi-drug resistant bacterial infections. The antimicrobia...
Journal Of Peptide Science
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Peptide‐based hydrogels as delivery systems for doxorubicin
Hydrogels (HGs) and nanogels (NGs) have been recently identified as innovative supramolecular materials for many applicati...
Journal Of Peptide Science
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Different directions for retro‐inverso peptides
error_outline You have to enabl...
Journal Of Peptide Science
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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin
Candida albicans is the principal opportunistic fungal pathogen in nosocomial settings and resistance to antifungal drugs ...
Journal Of Peptide Science
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Novel disintegrin‐like peptides derived from an amphibian skin cDNA sequence of Hypsiboas punctatus
Disintegrins comprise a family of small proteins that bind to and alter the physiological function of integrins, especiall...
Journal Of Peptide Science
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Chemical methods for studying the crosstalk between histone H2B ubiquitylation and H3 methylation
The reversible and dynamic post-translational modifications (PTMs) of histones in eukaryotic chromatin are intimately conn...
Journal Of Peptide Science
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Virtual screening and rational design of antioxidant peptides based on tryptophyllin L structures isolated from the Litoria rubella frog
Discovery of natural antioxidants has been carried out for decades relying mainly on experimental approaches that are comm...
Journal Of Peptide Science
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Editorial: “Peptides in biomaterials science: New trends and applications”
Early View e3379 EDITORIAL Carlos Mas-Moruno, Corresponding Author Bio...
Journal Of Peptide Science
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Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies
The development of devices for the precise and controlled delivery of therapeutics has grown rapidly over the last few dec...
Journal Of Peptide Science
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Structural and functional swapping of amyloidogenic and antimicrobial peptides: Redefining the role of amyloidogenic propensity in disease and host defense
Peptides constitute an essential component of all organisms' protein homeostasis ranging from bacteria, plants, and animal...
Journal Of Peptide Science
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Design, synthesis, and evaluation of the self‐assembled antimicrobial peptides based on the ovalbumin‐derived peptide TK913
The preparation, self-assembly, and antimicrobial activity of peptides based on TK913 is described. TK9Z4 incorporating a ...
Journal Of Peptide Science
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Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1
Human sine oculis homeobox homolog (SIX) 1 contains a homeodomain (HD), which is important for binding to DNA. In this stu...
Journal Of Peptide Science
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Clearance of oxytocin and its potentially enzyme resistant analogues in the OXT‐receptor compartment of the potassium depolarized rat myometrium
The time–response behaviour of a group of oxytocin analogues structurally modified on potential sites of oxytocin s...
Journal Of Peptide Science
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Tryptophan‐cardanol fluorescent nanoparticles inhibit α‐synuclein aggregation and disrupt amyloid fibrils
Protein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion...
Journal Of Peptide Science
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Solid phase diversity‐oriented lysine modification of cyclic peptides
Herein, we report a novel strategy for diversity-oriented lysine modification of cyclic peptides based on the orthogonal a...
Journal Of Peptide Science
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The life and work of Robert (Bob) C. Sheppard
The life and work of Robert Charles Sheppard (1932–2019), Bob Sheppard informally among friends, is outlined. He wa...
Journal Of Peptide Science
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FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages
A cathepsin B (Cat B)-responsive optical nanoprobe is designed and prepared for report of HL60 differentiation into macrop...
Journal Of Peptide Science
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Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1
Abstract Maximin 1 is a cationic, amphipathic antimicrobial peptide found in the skin secretions and brains of the Chinese...
Journal Of Peptide Science
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Self‐assembling systems comprising intrinsically disordered protein polymers like elastin‐like recombinamers
Despite lacking cooperatively folded structures under native conditions, numerous intrinsically disordered proteins (IDPs)...
Journal Of Peptide Science
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DIC/Oxyma‐based accelerated synthesis and oxidative folding studies of centipede toxin RhTx
Coupling reagents play crucial roles in the iterative construction of amide bonds for the synthesis of peptides and peptid...
Journal Of Peptide Science
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Chemical approaches for the preparation of ubiquitinated proteins via natural linkages
Ubiquitination is an important posttranslation modification (PTM) that regulates a variety of cellular processes, includin...
Journal Of Peptide Science
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Safety‐catch linkers for Fmoc solid‐phase synthesis of peptide thioesters and hydrazides by amide‐to‐imide activation
The use of C-terminal peptide thioesters and hydrazides in synthetic protein chemistry has inspired the search for optimal...
Journal Of Peptide Science
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