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Keratinocytes take part in the regulation of substance P in melanogenesis through the HPA axis
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Na...
Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling
Phillip J.M. Aifuwa I. Walston J. Wirtz D. The mechanobiology of aging.Annu. Rev. Biomed. Eng. 17: 113-141Hakozaki T. Swan...
Increase in inhibin beta A/Activin-A expression in the human epidermis and the suppression of epidermal stem/progenitor cell proliferation with aging
Giangreco A. Qin M. Pintar J.E. Watt F.M. Epidermal stem cells are retained in vivo throughout skin aging.Aging Cell. 7: 2...
Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells
Pym-5 promotes MIFT-dependent melanogenesis in vitro.The hallmark of differentiated melanocytes is the presence of melanin...
Evaluating differential expression of fibrosis-related genes and their correlation with blood vessel density in chronic cutaneous graft-versus-host disease
Background Sclerodermoid graft-versus-host disease (GVHD) is the most severe form of chronic GVHD (c...
TRPA1 promotes melanosome phagocytosis in keratinocytes via PAR-2/CYLD axis
Microtubules are involved in melanosome redistribution from dispersed to clustered (centripetal transport) [[18]Evans R.D....
Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis
Griffiths C.E.M. Armstrong A.W. Gudjonsson J.E. J. Bark. Psoriasis Lancet. 397: 1301-1315Parisi R. Iskandar I.Y.K. Kontopa...
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Anti-inflammatory effects of differential molecular weight Hyaluronic acids on UVB-induced calprotectin-mediated keratinocyte inflammation
Highlights•uLMW-HA decreased UVB-induced IL-6 secretion.•uLMW-HA downregulated Calprotectin-induced TRAF6 expression.•CD44...
Impaired holocrine secretion and intracellular retention of autophagosomal components in comedones
Comedo, a clogged hair follicle, is one of the predisposing factors of acne. Comedo formation has been known to resu...
Aberrant serine protease activities in atopic dermatitis
New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.J. D...
Actinic lentigines from Japanese and European volunteers share similar impaired biological functions
Bastiaens M. Hoefnagel J. Westendorp R. Vermeer B.J. Bouwes J.N. Bavinck, Solar lentigines are strongly related to sun exp...
Staphylococcus aureus phenol-soluble modulins induce itch sensation
Atopic dermatitis (AD) is one of the most common debilitating inflammatory skin diseases and often results in lifelo...
Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways
Background Yohimbine hydrochloride (YH) is a prescription drug to treat erectile dysfunction. It als...
Abnormal inflammatory traits and downregulated caveolin-1 expression in monocytes of psoriasis patients may be associated with psoriatic inflammation and atherosclerosis
Background Monocytes and macrophages are implicated in inflammation and atherosclerosis, whereas mon...
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, T...
The role of HMGB1 in inflammatory skin diseases
Harris H.E. Andersson U. Pisetsky D.S. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.Nat. R...
Risk factors for sepsis and effects of pretreatment with systemic steroid therapy for underlying condition in SJS/TEN patients: Results of a nationwide cross-sectional survey in 489 Japanese patients
Background Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening ...
Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis
Background CXCL4, a chemokine with anti-angiogenic property, is involved in systemic sclerosis (SSc)...
2-Aminoethyl Diphenylborinate Inhibits Bleomycin-Induced Skin and Pulmonary Fibrosis via Interrupting Intracellular Ca2+ Regulation
Department of Dermatology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical ...
Intragenic copy number variation in mouse epiplakin 1 (Eppk1) and the conservation of the repeat structures in the lower vertebrates
Departments of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan...
H3K27Ac modification and gene expression in psoriasis
Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Medicine C, Sheba Medical Center, Tel H...
A multicenter, open-label, uncontrolled, single-arm phase 2 study of tirabrutinib, an oral Bruton’s tyrosine kinase inhibitor, in pemphigus
Background The treatment of pemphigus is based on systemic corticosteroid use and adjuvant therapies, ...
Nicotine affects tight junction barriers via alpha7 nicotine-like acetylcholine receptor in keratinocytes
Smoking negatively affects the skin, causing wrinkles, dryness, blemishes with delayed wound healing, and decreased ...
The regional distribution of melanosomes in the epidermis affords a localized intensive photoprotection for basal keratinocyte stem cells
Sánchez-Danés A. Blanpain C. Deciphering the cells of origin of squamous cell carcinomas.Nat. Rev. Cancer. 2018; 18: 549-5...
Bone morphogenetic protein-7 inhibits endothelial-to-mesenchymal transition in primary human umbilical vein endothelial cells and mouse model of systemic sclerosis via Akt/mTOR/p70S6K pathway
Background Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder that causes ...
Chromatin dynamics and epigenetics in skin stress adaptation
Pittelkow MR Psoriasis: more than skin deep.Nat Med. 2005; 11: 17-18View in Article ...
Mutations in γ-secretase subunit–encoding PSENEN gene alone may not be sufficient for the development of acne inversa
Background The effects of PSENEN mutations in patients with acne inversa (AI) are poorly understood. Hyperpro...
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