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Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Bridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia
Leprosy, caused by Mycobacterium leprae (M. leprae), primarily manifests with cutaneous and peripheral nerve invo...
Simultaneous merkel cell carcinoma and acute myeloid leukaemia: A diagnostic challenge
Simultaneous merkel cell carcinoma and acute myeloid leukaemia: A diagnostic challenge
Merkel cell carcinoma is a very aggressive primary skin tumour with a high risk of local recurrences and lymphatic and dis...
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Complete loss of lineage defining antigens in two cases of B-cell malignancies following CAR-T therapy
Targeted immunotherapy is a promising approach in treating high-risk and refractory/relapsed lymphoid malignancies. Althou...
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Systemic ALK-negative anaplastic large cell lymphoma with NPM1::TYK2 rearrangement
Anaplastic large cell lymphoma (ALCL) is a rare subtype of non-Hodgkin lymphoma, with most cases harboring ALK gene rearra...
An unusual case of pure erythroid leukemia with normal karyotype and NPM1 mutation
An unusual case of pure erythroid leukemia with normal karyotype and NPM1 mutation
Pure erythroid leukemia (PEL) is an extremely rare subtype of acute myeloid leukemia (AML). Although not specific, PEL is ...
CD8-positive T-cell lymphoproliferative disorder of the uterus: a new subtype of indolent extranodal T-cell neoplasm?
CD8-positive T-cell lymphoproliferative disorder of the uterus: a new subtype of indolent extranodal T-cell neoplasm?
A 51-year-old female with menorrhagia was found to have a cervical polyp. Polypectomy and endometrial curettage showed an ...
Infectious mononucleosis complicated by transitory Epstein-Barr virus infection of T and natural killer cells
Infectious mononucleosis complicated by transitory Epstein-Barr virus infection of T and natural killer cells
Epstein-Barr virus (EBV) typically infects B cells in infectious mononucleosis (IM), but a rare case shows EBV infection i...
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid...
Validation of an automated iron stain process for use with bone marrow aspirate smear slides
Validation of an automated iron stain process for use with bone marrow aspirate smear slides
The assessment of bone marrow iron stores is typically performed on an aspirate smear slide that has been manually stained...
Cytogenetic and pathologic characterization of MYC-rearranged B-cell lymphomas in pediatric and young adult patients
Cytogenetic and pathologic characterization of MYC-rearranged B-cell lymphomas in pediatric and young adult patients
MYC-rearranged B-cell lymphoma (BCL) in the pediatric/young adult (YA) age group differs substantially in disease composit...
In memorium: Dr. Zeba Singh
In memorium: Dr. Zeba Singh
We are deeply saddened by the recent passing of Dr. Zeba Singh, who left us in Novem...
Gamma-delta T-cell acute lymphoblastic lymphoma/leukemia: a report of a rare entity
Gamma-delta T-cell acute lymphoblastic lymphoma/leukemia: a report of a rare entity
Gamma delta (γδ) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is a rare, aggressive subtype of T-lymphoi...
Secondary plasma cell leukaemia (PCL) with plasmablastic morphology
Secondary plasma cell leukaemia (PCL) with plasmablastic morphology
A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5%...
The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia
The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia
In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of ...
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
Langerhans cell histiocytosis (LCH) of the stomach is rare. Moreover, it is usually found in pediatric patients with syste...
ALK-positive large B-cell lymphoma (ALK + LBCL) with aberrant CD3 expression
ALK-positive large B-cell lymphoma (ALK + LBCL) with aberrant CD3 expression
ALK-positive ( +) large B cell lymphoma (ALK + LBCL) is a rare distinct subtype of diffuse large B cell ...
What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. T...
Transdifferentiation of diffuse large B-cell lymphoma to a poorly differentiated neoplasm following CAR T-cell therapy
Transdifferentiation of diffuse large B-cell lymphoma to a poorly differentiated neoplasm following CAR T-cell therapy
Chimeric antigen receptor T-cell (CAR-T) therapy is a recent advancement in precision medicine with promising results for ...
Molecular characterization of a rare case of high-grade B-cell lymphoma with MYC, BCL2, BCL6, and CCND1 rearrangements
Molecular characterization of a rare case of high-grade B-cell lymphoma with MYC, BCL2, BCL6, and CCND1 rearrangements
Quadruple-hit lymphomas are extremely rare non-Hodgkin lymphomas with a reported dismal prognosis in the few reported case...
Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review
Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review
Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without...