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Fatal Late-Onset Presentation of Ornithine Transcarbamylase (OTC) Deficiency: A Case Report Highlighting Diagnostic Challenges and Cerebral Complications
Fatal Late-Onset Presentation of Ornithine Transcarbamylase (OTC) Deficiency: A Case Report Highlighting Diagnostic Challenges and Cerebral Complications
Ornithine transcarbamylase deficiency caused by mutations in the OTC gene is the most common inherited disease of the urea...
The Necessity of Age Stratified Validation of Martin Hopkins Formula: Observations from a Meta-Analysis
The Necessity of Age Stratified Validation of Martin Hopkins Formula: Observations from a Meta-Analysis
Martin Hopkins formula proposed in 2013 uses a varying factor based on the triglyceride and non-HDL cholesterol values, in...
Utility and Sensitivity of Gene Polymorphism in Early Prediction and Association with Risk of Metabolic Primary Antiphospholipid Syndrome: Cohort Study
Utility and Sensitivity of Gene Polymorphism in Early Prediction and Association with Risk of Metabolic Primary Antiphospholipid Syndrome: Cohort Study
Toll-like Receptor 10 (TLR10) represents the sole member of the human toll-like receptor family that inhibits the innate i...
Clinical, Biochemical and Molecular Findings of Two PMM2-CDG Cases from India
Clinical, Biochemical and Molecular Findings of Two PMM2-CDG Cases from India
Congenital Disorders of Glycosylation (CDG) represent a diverse and complex group of inherited metabolic disorders, with m...
Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review
Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review
Cancer remains one of the most pressing global health concerns, ranking as the second leading cause of death worldwide. Ox...
Exploring the Therapeutic Potential of Esculetin in Mitigating Cyclophosphamide-Induced Hepato-Toxicity
Exploring the Therapeutic Potential of Esculetin in Mitigating Cyclophosphamide-Induced Hepato-Toxicity
Cyclophosphamide, an extensively utilized alkylating agent in oncological therapies, is correlated with considerable hepat...
Identification of Genes and Pathways Involved in Breast Cancer Subtypes through Expression Meta-analysis
Identification of Genes and Pathways Involved in Breast Cancer Subtypes through Expression Meta-analysis
Early diagnosis of breast cancer (BC), that whether it is invasive or non-invasive, is crucial in the field of breast surg...
Do the Early Pregnancy Serum Levels of VEGF & PlGF Predict the Onset of Preeclampsia: An Experience from a Tertiary Center
Do the Early Pregnancy Serum Levels of VEGF & PlGF Predict the Onset of Preeclampsia: An Experience from a Tertiary Center
This study was conducted to evaluate the utility of serum vascular endothelial growth factor (VEGF) and placental growth f...
The Implication of ENSA, K-ATP Channel Encoding Gene Variations in Type 1 Diabetes in Children of South Indian Population
The Implication of ENSA, K-ATP Channel Encoding Gene Variations in Type 1 Diabetes in Children of South Indian Population
A polygenic condition called type 1 diabetes mellitus (T1D), causes hyperglycemia inferable from insulin deficiency, invol...
Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease
Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease
Members of the Solanaceae family, also known as peppers, widely celebrate the culinary and medicinal significance of Capsi...
Circadian Rhythm Desynchrony and Its Correlation with Insulin Resistance in Type 2 Diabetes
Circadian Rhythm Desynchrony and Its Correlation with Insulin Resistance in Type 2 Diabetes
The biological rhythm of the human body runs in a 24-h cycle in which it undergoes various interactions with exogenous fac...
and Serve as Essential Gatekeepers for Monitoring In Vitro Production of Pro-inflammatory Cytokines in THP-1 Monocytic Cells
and Serve as Essential Gatekeepers for Monitoring In Vitro Production of Pro-inflammatory Cytokines in THP-1 Monocytic Cells
THP-1 cell lines are routinely utilized as an in vitro model to investigate monocyte and macrophage functions. In this stu...
Enhanced Anticancer Efficacy of Selenium Nanoparticles Encapsulated in Niosomes: A Novel Therapeutic Strategy
Enhanced Anticancer Efficacy of Selenium Nanoparticles Encapsulated in Niosomes: A Novel Therapeutic Strategy
Oral squamous cell carcinoma persists as a formidable global health challenge, characterized by notably high morbidity and...
Heavy Metal Exposure and its Health Implications: A Comprehensive Review
Heavy Metal Exposure and its Health Implications: A Comprehensive Review
Toxic metal exposure is a global health concern with serious implications for human well-being. Metals such as lead, mercu...
hsa-miR-3529-5p through F2RL3 Regulation as an Enhancer of Sensitivity to Cisplatin
hsa-miR-3529-5p through F2RL3 Regulation as an Enhancer of Sensitivity to Cisplatin
The emergence of drug resistance in gastric cancer presents a critical challenge in oncological treatments, often leading ...
Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
Folic acid (FA) supplementation in sickle cell disease (SCD) patients lead to accumulation of unmetabolized folic acid (UM...
Optimization of Automated Dimethylmethylene Blue Assay for Quantification of Pediatric Urine Samples
Optimization of Automated Dimethylmethylene Blue Assay for Quantification of Pediatric Urine Samples
The metachromatic dye dimethylmethylene blue is used to quantify total glycosaminoglycans in urine. Understanding the inte...
Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review
Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review
The use of drugs in chemotherapy poses numerous side effects. Hence the use of natural substances that can help in the pre...
Circulating miRNA-373 and Vascular Endothelial Growth Factor as Potential Biomarkers for Early Detection of Breast Cancer
Circulating miRNA-373 and Vascular Endothelial Growth Factor as Potential Biomarkers for Early Detection of Breast Cancer
Breast cancer is the leading cause of cancer-related mortality among women worldwide. MicroRNAs (miRNAs), short non-coding...
miR-30b-5p Promotes Medulloblastoma Cell Proliferation by Regulating Stem Cell Factors NANOG, BMI1, Tumor Suppressor Gene P53 and the Shh-Gli1 Pathway
miR-30b-5p Promotes Medulloblastoma Cell Proliferation by Regulating Stem Cell Factors NANOG, BMI1, Tumor Suppressor Gene P53 and the Shh-Gli1 Pathway
Medulloblastoma (MB), a malignant tumour arising in the brain, exhibits distinct microRNA expression patterns. One such mi...
Assessment of Oxidative Stress Levels in Women with Different Phenotypes of Polycystic Ovary Syndrome and its Correlation with Lipid and Hormonal Profile
Assessment of Oxidative Stress Levels in Women with Different Phenotypes of Polycystic Ovary Syndrome and its Correlation with Lipid and Hormonal Profile
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder and one of the leading causes of infertility in women....
Secretion of IL-6 and TGF-β2 by Colon Cancer Cells May Promote Resistance to Chemotherapy
Secretion of IL-6 and TGF-β2 by Colon Cancer Cells May Promote Resistance to Chemotherapy
Colon rectal cancer still stands as the third most common form of cancer worldwide. 90% of colorectal cancer failure is at...
Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome
Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome
Polycystic ovarian syndrome (PCOS) is associated with low-grade systemic inflammation and an increase in inflammation mark...
The Increase of Soluble Urokinase Plasminogen Activator Receptor in Heart Failure is Related to Disease Severity and Cardiac Mortality
The Increase of Soluble Urokinase Plasminogen Activator Receptor in Heart Failure is Related to Disease Severity and Cardiac Mortality
Heart failure (HF) is a life-threatening syndrome with high prevalence and mortality rates. Soluble urokinase plasminogen ...
Role of Cell-free DNA as a Non-Invasive Biomarker in the Detection of Head and Neck Squamous Cell Carcinoma
Role of Cell-free DNA as a Non-Invasive Biomarker in the Detection of Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinomas (HNSCC) are the sixth leading cancer by incidence worldwide. Small fragments of cel...
Metabolomic Biomarkers for Prognosis in Non-Muscle Invasive Bladder Cancer: A Comprehensive Systematic Review and Meta-Analysis
Metabolomic Biomarkers for Prognosis in Non-Muscle Invasive Bladder Cancer: A Comprehensive Systematic Review and Meta-Analysis
The prognostic biomarkers, or metabolites, have gained relevance due to their significance in predicting clinical and ther...
Role of Blood Cell Indexes in Progresses to ESRD
Role of Blood Cell Indexes in Progresses to ESRD
Chronic kidney disease (CKD) is a complex health condition characterized by the gradual loss of renal function, often lead...
Spirulina Platensis Alleviates γ- Radiation-Induced Brain Damage by Attenuating Oxidative Stress and Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels in Male Albino Rats
Spirulina Platensis Alleviates γ- Radiation-Induced Brain Damage by Attenuating Oxidative Stress and Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels in Male Albino Rats
Ionizing radiation can irreversibly damage the brain cells’ function and structure. Spirulina platensis (Sp...
The First-Ever Investigation of SNP rs119461977 in SECISBP2/SBP2 Gene and its Implications for Hypothyroidism: A Novel Case–Control Research
The First-Ever Investigation of SNP rs119461977 in SECISBP2/SBP2 Gene and its Implications for Hypothyroidism: A Novel Case–Control Research
Hypothyroidism is one of the most prevalent endocrine disorders worldwide. Various genes are involved in thyroid hormone p...
Exploring the Role of Serum Lysyl Oxidase (LOX) Levels and LOX Gene Polymorphism (G473A) in Diabetic Nephropathy
Exploring the Role of Serum Lysyl Oxidase (LOX) Levels and LOX Gene Polymorphism (G473A) in Diabetic Nephropathy
Diabetic Nephropathy (DN) is a leading microvascular complication of diabetes with poor prognosis. Extra cellular matrix a...
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