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iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles
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Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina
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Sex-dependent effects of monomeric α-synuclein on calcium and cell death of lateral hypothalamic mouse neurons are altered by orexin
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Muscarinic Modulation of Synaptic Transmission and Short-Term Plasticity in the Dorsal and Ventral Hippocampus
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Heparan sulfate proteoglycans: Mediators of cellular and molecular Alzheimer's disease pathogenic factors via tunnelling nanotubes?
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A novel in vitro model for investigating oligodendroglial maturation and myelin deposition under demyelinating and remyelinating conditions: Impact of microglial depletion and repopulation
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iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death
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Progress of reprogramming astrocytes into neuron
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Disease modifying effects of the amyloid-beta protofibril-selective antibody mAb158 in aged Tg2576 transgenic mice
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Lecanemab demonstrates highly selective binding to Aβ protofibrils isolated from Alzheimer's disease brains
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Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons
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Sphingosine kinase 2 regulates protein ubiquitination networks in neurons
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Reduced platelet activation and thrombus formation in male transgenic model mice of Alzheimer's disease suggests early sex-specific differences in platelet pathophysiology
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Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/β-catenin signaling in hypertension
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The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ
The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ
The exocyst protein complex is important for targeted vesicle fusion in a variety of cell types, however, its function in ...
Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin
Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin
BackgroundThe EphB receptor tyrosine kinase family participates in intricate signaling pathways that orchestrate neural ne...
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Alzheimer's disease (AD) is a neurodegenerative disorder that develops over decades. Glial cells, including astrocytes are...
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease
Volume 128, March 2024, 103919Author links open overlay panel, , , , , , Highlights•Patient specific midbrain organoids mo...
A neural mass model for disturbance of alpha rhythm in the minimal hepatic encephalopathy
A neural mass model for disturbance of alpha rhythm in the minimal hepatic encephalopathy
Hepatic encephalopathy (HE) is a spectrum of neuropsychiatric abnormalities associated with liver dysfunction, which is a ...
Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Proper circuit function in the mammalian brain relies upon cell-cell communication through two main types of chemical syna...
TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges
TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges
Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane glycoprotein that plays a crucial role in the regul...
Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates
Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates
Atp1a2ATPase Na+/K+ transporting subunit Alpha2Atp1b2ATPase Na+/K+ transporting subunit Beta2DlatMitochondrial dehydrogena...
Cdc42 activation is necessary for heterosynaptic cooperation and competition
Cdc42 activation is necessary for heterosynaptic cooperation and competition
Synapses change their weights in response to neuronal activity and in turn, neuronal networks alter their response propert...
Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb
Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb
The olfactory bulb (OB) is found in all vertebrates and is the first relay station of the olfactory information in the bra...
Neuron navigators: A novel frontier with physiological and pathological implications
Neuron navigators: A novel frontier with physiological and pathological implications
The last couple of decades have witnessed a tremendous growth in the field of medical research associated with overall hea...
The elastin-derived peptide (VGVAPG) activates autophagy in neuroblastoma (SH-SY5Y) cells via peroxisome proliferator-activated receptor gamma (PPARγ)
The elastin-derived peptide (VGVAPG) activates autophagy in neuroblastoma (SH-SY5Y) cells via peroxisome proliferator-activated receptor gamma (PPARγ)
Autophagy is a self-degradative process important for balancing the sources of energy and involved in the development of A...
Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation
Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation
Amyotrophic lateral sclerosis (ALS) affects millions of people worldwide, and till now there is no cure for this disease. ...
Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair
Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair
AbbreviationsADAMA disintegrin and metalloproteaseAICDAPP intracellular domainAPPamyloid-β precursor proteinDAPTN-[N-(3,5-...
The NIDA Avenir award in genetics or epigenetics of substance use disorders
The NIDA Avenir award in genetics or epigenetics of substance use disorders
NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs) was launched to support early stage...
The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease
The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease
Niemann-Pick type C disease (NP-C) is an autosomal recessive lysosomal storage disease caused by a deficiency in either th...
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