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Fluorine labelling for in situ 19F NMR in oriented systems
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A comprehensive assessment of selective amino acid 15N-labeling in human embryonic kidney 293 cells for NMR spectroscopy
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Reconstitution and resonance assignments of yeast OST subunit Ost4 and its critical mutant Ost4V23D in liposomes by solid-state NMR
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Short and long range 2D 15N–15N NMR correlations among peptide groups by novel solid state dipolar mixing schemes
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Beyond slow two-state protein conformational exchange using CEST: applications to three-state protein interconversion on the millisecond timescale
Although NMR spectroscopy is routinely used to study the conformational dynamics of biomolecules, robust analyses of the d...
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The NMR signature of maltose-based glycation in full-length proteins
Reducing sugars can spontaneously react with free amines in protein side chains leading to posttranslational modifications...
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Decorating phenylalanine side-chains with triple labeled 13C/19F/2H isotope patterns
We present an economic and straightforward method to introduce 13C-19F spin systems into the deuterated aromatic side chai...
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DNP-assisted solid-state NMR enables detection of proteins at nanomolar concentrations in fully protonated cellular milieu
With the sensitivity enhancements conferred by dynamic nuclear polarization (DNP), magic angle spinning (MAS) solid state ...
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Prediction of order parameters based on protein NMR structure ensemble and machine learning
The fast motions of proteins at the picosecond to nanosecond timescale, known as fast dynamics, are closely related to pro...
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Enabling site-specific NMR investigations of therapeutic Fab using a cell-free based isotopic labeling approach: application to anti-LAMP1 Fab
Monoclonal antibodies (mAbs) are biotherapeutics that have achieved outstanding success in treating many life-threatening ...
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Fluorine-19 labeling of the tryptophan residues in the G protein-coupled receptor NK1R using the 5-fluoroindole precursor in Pichia pastoris expression
In NMR spectroscopy of biomolecular systems, the use of fluorine-19 probes benefits from a clean background and high sensi...
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19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor
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Uniform [13C,15N]-labeled and glycosylated IgG1 Fc expressed in Saccharomyces cerevisiae
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5D solid-state NMR spectroscopy for facilitated resonance assignment
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Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data
Many proteins can adopt multiple conformations which are important for their function. This is also true for proteins and ...
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Paramagnetic NMR to study iron sulfur proteins: 13C detected experiments illuminate the vicinity of the metal center
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Synthesis of a 13C-methylene-labeled isoleucine precursor as a useful tool for studying protein side-chain interactions and dynamics
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Breaking boundaries: TINTO in POKY for computer vision-based NMR walking strategies
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A thermosensitive gel matrix for bioreactor-assisted in-cell NMR of nucleic acids and proteins
Introducing the flow through the bioreactor has revolutionized in-cell NMR spectroscopy by prolonging the measurement time...
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Strategies for acquisition of resonance assignment spectra of highly dynamic membrane proteins: a GPCR case study
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Improved spectral resolution of [13C,1H]-HSQC spectra of aromatic amino acid residues in proteins produced by cell-free synthesis from inexpensive 13C-labelled precursors
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Studying micro to millisecond protein dynamics using simple amide 15N CEST experiments supplemented with major-state R2 and visible peak-position constraints
Over the last decade amide 15N CEST experiments have emerged as a popular tool to study protein dynamics that involves exc...
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E. coli “Stablelabel” S30 lysate for optimized cell-free NMR sample preparation
Cell-free (CF) synthesis with highly productive E. coli lysates is a convenient method to produce labeled proteins for NMR...
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1H-detected characterization of carbon–carbon networks in highly flexible protonated biomolecules using MAS NMR
In the last three decades, the scope of solid-state NMR has expanded to exploring complex biomolecules, from large protein...
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Efficient 18.8 T MAS-DNP NMR reveals hidden side chains in amyloid fibrils
Amyloid fibrils are large and insoluble protein assemblies composed of a rigid core associated with a cross-β arrange...
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Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes
The accelerated acquisition of multidimensional NMR spectra using sparse non-uniform sampling (NUS) has been widely adopte...
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NMR detection and conformational dependence of two, three, and four-bond isotope shifts due to deuteration of backbone amides
NMR isotope shifts occur due to small differences in nuclear shielding when nearby atoms are different isotopes. For molec...
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A methyl-TROSY based 13C relaxation dispersion NMR experiment for studies of chemical exchange in proteins
A methyl Transverse Relaxation Optimized Spectroscopy (methyl-TROSY) based, multiple quantum (MQ) 13C Carr-Purcell-Meiboom...
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Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction
A single experimental method alone often fails to provide the resolution, accuracy, and coverage needed to model integral ...
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Assessing the applicability of 19F labeled tryptophan residues to quantify protein dynamics
Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to study the dynamics of biomolecules in solution. Most N...
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