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Units containing telomeric repeats are prevalent in subtelomeric regions of a Mesorhabditis isolate collected from the Republic of Korea
Units containing telomeric repeats are prevalent in subtelomeric regions of a Mesorhabditis isolate collected from the Republic of Korea
Mesorhabditis is known for its somatic genome being only a small portion of the germline genome due to programmed DNA elim...
Weighted gene co-expression network analysis and identification of ginsenoside biosynthesis candidate genes for ginseng adventitious roots under MeJA treatment
Weighted gene co-expression network analysis and identification of ginsenoside biosynthesis candidate genes for ginseng adventitious roots under MeJA treatment
Ginseng (Panax ginseng) is an herb with a long history and a wide range of applications. Ginsenoside is one of the most re...
Integrated analysis of single-cell RNA-seq and bulk RNA-seq revealed key genes for bone metastasis and chemoresistance in prostate cancer
Integrated analysis of single-cell RNA-seq and bulk RNA-seq revealed key genes for bone metastasis and chemoresistance in prostate cancer
Prostate cancer (PCa) is a serious malignancy. The main causes of PCa aggravation and death are unexplained resistance to ...
GVAF: generalized, flexible filtering software for annotated variant files
GVAF: generalized, flexible filtering software for annotated variant files
In the rapidly advancing field of genomics, many tools have been developed to interpret genetic variants using next-genera...
Genome-wide identification and expression profiling of the Wnt gene family in three abalone species
Genome-wide identification and expression profiling of the Wnt gene family in three abalone species
The Wnt gene family plays pivotal roles in a variety of biological processes including cell proliferation and differentiat...
Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing
Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing
Persicaria amphibia, a member of the Polygonaceae family, exists both aquatic and terrestrial forms. It is native to North...
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing
Hepatocellular carcinoma (HCC) is a highly malignant tumor; however, its immune microenvironment and mechanisms remain elu...
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Transcriptome analysis of tilapia streptococcus agalactiae in response to baicalin
Streptococcus agalactiae (S. agalactiae) is a highly pathogenic bacterial pathogen in aquatic animals. Our previous study ...
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
A novel CLRN2 variant: expanding the mutation spectrum and its critical role in isolated hearing impairment
Biallelic variants in the CLRN2 gene have been reported to cause autosomal recessive profound hearing impairment in humans...
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity
Congenital anomalies of the knee are a spectrum of rare disorders with wide clinical and genetic variability, which are ma...
Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease
Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson’s disease
Parkinson’s disease (PD) is a progressive neuro-degenerative disorder most common in older adults which is associate...
Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets
Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets
The permutation test has been widely used to provide the p-values of statistical tests when the standard test statistics d...
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis
Darier’s disease (DD) is a skin disorder caused by mutations in the ATP2A2 gene. Researchers have been investigating...
Granzyme mRNA-miRNA interaction and its implication to functional impact
Granzyme mRNA-miRNA interaction and its implication to functional impact
Granzyme activity can affect the processing and stability of miRNAs within target cells. They also could induce changes in...
Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)
Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia)
In Korea, only Polygala tenuifolia is registered as Polygalae Radix in the pharmacopoeia, while in China, both P. tenuifol...
Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets
Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets
Exposure to particulate matter (PM) and house dust mite (HDM) can change the expression patterns of inflammation-, oxidati...
eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells
eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells
Eukaryotic elongation factor 1A1 (eEF1A1) is an RNA-binding protein that is associated with PARK2 activity in cells, sugge...
Transcriptome sequencing of the endangered land snail Karaftohelix adamsi from the Island Ulleung: De novo assembly, annotation, valuation of fitness genes and SSR markers
Transcriptome sequencing of the endangered land snail Karaftohelix adamsi from the Island Ulleung: De novo assembly, annotation, valuation of fitness genes and SSR markers
The Bradybaenidae snail Karaftohelix adamsi is endemic to Korea, with the species tracked from Island Ulleung in North Gye...
Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer
Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer
Colon cancer is the third most common cancer globally. The expression of histone deacetylase 3 (HDAC3) is upregulated, whe...
STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells
STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells
The apoptosis-resistant pulmonary arterial endothelial cells (PAECs) are known to be major players in the pulmonary remode...
A study on construction of a prognosis model for liver cancer based on analgesic targets and screening therapeutic drugs
A study on construction of a prognosis model for liver cancer based on analgesic targets and screening therapeutic drugs
Liver cancer is one of the most malignant liver diseases in the world, and the 5-year survival rate of such patients is lo...
Molecular characterization of positively selected genes contributing aquatic adaptation in marine mammals
Molecular characterization of positively selected genes contributing aquatic adaptation in marine mammals
Marine mammals, which have evolved independently into three distinct lineages, share common physiological features that co...
MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis
MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis
In a previous study, we found that the expression of microRNA 429 (MIR429) was decreased in dextran sodium sulfate (DSS)-i...
In silico identification and expression analysis of superoxide dismutases in Tenebrio molitor
In silico identification and expression analysis of superoxide dismutases in Tenebrio molitor
Insects encounter various environmental stresses, in response to which they generate reactive oxygen species (ROS). Supero...
Immune micro-environment analysis and drug screening for ovarian endometriosis
Immune micro-environment analysis and drug screening for ovarian endometriosis
Patients of ovary endometriosis have an abnormal immune micro-environment, leading to endometrial tissue that from retrogr...
A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response
A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response
NR4A family genes play crucial roles in cancers. However, the role of NR4A family genes in cancers remains paradoxical as ...
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
In humans, ACTN2 mutations are identified as highly relevant to a range of cardiomyopathies such as DCM and HCM, while the...
Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population
Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population
Colorectal cancer (CRC) is the 3rd most common cancer in the world and colonic carcinogenesis is a multifactorial disease ...
Genome-wide identification of cold shock proteins (CSPs) in sweet cherry (Prunus avium L.) and exploring the differential responses of PavCSP1 and PavCSP3 to low temperature and salt stress
Genome-wide identification of cold shock proteins (CSPs) in sweet cherry (Prunus avium L.) and exploring the differential responses of PavCSP1 and PavCSP3 to low temperature and salt stress
Cold shock proteins (CSPs) are ubiquitous nucleic acid-binding proteins involved in growth, development, and stress respon...
Heterogeneity of hepatocellular carcinoma that responds differently to combination therapy with TACE and Sorafenib as determined by digital spatial gene expression profiling
Heterogeneity of hepatocellular carcinoma that responds differently to combination therapy with TACE and Sorafenib as determined by digital spatial gene expression profiling
The combination of Sorafenib and transcatheter arterial chemoembolization (TACE) exhibits limited efficacy in the treatmen...
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