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The hidden costs of imperfection: transcription errors in protein aggregation diseases
At first glance, biological systems appear to operate with remarkable precision and order. Yet, closer examination reveals...
Spliceosome complex and neurodevelopmental disorders
The spliceosome catalyzes precursor messenger RNA (pre-mRNA) splicing, a function carried out by a ribonucleoprotein (RNP)...
Biological roles of nonsense-mediated RNA decay: insights from the nervous system
Nonsense-mediated RNA decay (NMD) is a highly conserved pathway originally discovered by virtue of its ability to recogniz...
Transcriptional adaptation: where mRNA decay meets genetic compensation
Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control mechanism that safeguards cells against faulty...
The HNRNPs and neurodevelopmental disorders
The HNRNP gene family encodes for over 30 distinct heterogeneous nuclear ribonucleoproteins [1]. These RNA-binding protein...
NOVA1/2 genes and alternative splicing in neurodevelopment
Volume 93, August 2025, 102373Author links open overlay panelNOVA1 and NOVA2 are neuron-specific RNA-binding proteins esse...
Unlocking regeneration: how partial reprogramming resembles tissue healing
Partial reprogramming achieved by the transient expression of the transcription factors (TFs) Oct4, Sox2, Klf4 and C-Myc (...
Molecular basis of cell fate plasticity — insights from the privileged cells
In the post-Yamanaka era, the rolling balls on Waddington’s hilly landscape not only roll downward, but also go upward or ...
Stem cell models of human embryo implantation and trophoblast invasion
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Recent advances in interspecies chimeras and organogenesis
The global shortage of transplantable organs remains a critical challenge in modern medicine. Every year, thousands of pat...
mRNA translational control of regeneration
Regeneration is broadly defined as the repair or regrowth of cells, tissues, organs, and organisms [1]. A salient feature ...
Lineage-specific regulatory evolution: insights from massively parallel reporter assays
Lineage-specific genetic variants play a key role in evolutionary divergence, particularly through changes in cis-regulato...
Addressing missing context in regulatory variation across primate evolution
In primates, loci associated with adaptive trait variation often fall in noncoding regions. Understanding the mechanisms l...
Exploring the origin of the development: totipotent stem cells
In vitro cultured stem cells correspond to different stages of embryonic development. Mammalian embryonic development begi...
Centromere regulation in the germline and early embryo
Centromeres are essential for genome inheritance, serving as sites for kinetochore assembly and for final sister chromatid...
Why and how paternal mitochondrial DNA gets cut out of the inheritance
Mitochondrial DNA (mtDNA) is inherited maternally across animals, yet the evolutionary rationale behind this unusual mode ...
Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice
Germ cells are the origin of totipotency, giving rise to new individuals. To fulfill this role, while faithfully replicati...
Transcription-Export complex in neurodevelopmental disorders
The genomic information is insulated in the nucleus of all eukaryotic cells. Error-free transcription needs to be followed...
Evolution and ecology of commensal gut protists: recent advances
The microbial community colonizing the animal gut includes all domains of life, including eukaryotic microbes. Historicall...
Linking phenotype to genotype using comprehensive genomic comparisons
Comparative genomics is a powerful approach to illuminate the genetic basis of phenotypic diversity across macro-evolution...
Diversity of human skin three-dimensional organotypic cultures
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Cell–cell interactions between transplanted retinal organoid cells and recipient tissues
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Circuit integration by transplanted human neurons
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Control of cell fate upon transcription factor–driven cardiac reprogramming
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Unveiling the potential: implications of successful somatic cell-to-ganglion organoid reprogramming
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The power of proximity: mechanisms and biological roles of transvection
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Genome folding and zygotic genome activation in mammalian preimplantation embryos
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Better together: how cooperativity influences transcriptional bursting
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Emerging interactions between RNA methylation and chromatin architecture
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Editorial overview: Epitranscriptomics: Exploring a new frontier in health and disease
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