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Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing
Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing
Successful development requires both precise timing of cellular processes, such as division and differentiation, and tight...
Toward a comprehensive view of gene architecture during transcription
Toward a comprehensive view of gene architecture during transcription
In multicellular organisms, the same genetic code gives rise to a large diversity of cell types. A fully stretched out ver...
The influencers' era: how the environment shapes chromatin in 3D
The influencers' era: how the environment shapes chromatin in 3D
Environment–epigenome interactions are emerging as contributors to disease risk and health outcomes. In fact, organisms ou...
Inheritance of epigenetic transcriptional memory
Inheritance of epigenetic transcriptional memory
An improved understanding of nuclear architecture has begun to reveal how genome organization affects transcription and ot...
Corrigendum to: “PRC2 accessory factors: rheostats for cell fate decision?” [Curr Opin Genet Dev 84 (2024) 102137]
Corrigendum to: “PRC2 accessory factors: rheostats for cell fate decision?” [Curr Opin Genet Dev 84 (2024) 102137]
Volume 85, April 2024, 102157Author links open overlay panelHina Bharti *, Sungwook Han *, Han-Wen Chang *, Danny Reinberg...
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain–containing factors
In this perspective, we discuss the emerging class of epigenetic cancer therapies targeting acetylrecognition domain–conta...
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia
To make a multicellular organism, genes need to be transcribed at the right developmental stages and in the right tissues....
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
Mitochondrial metabolism and the continuing search for ultimate regulators of developmental rate
A fundamental question in developmental biology is how the pace of developmental processes is controlled from a cell biolo...
Temporal patterning of the vertebrate developing neural tube
Temporal patterning of the vertebrate developing neural tube
scRNAseq data has been obtained from the indicated references (forebrain, midbrain, hindbrain: [34], spinal cord: [31], re...
The significance of ultradian oscillations in development
The significance of ultradian oscillations in development
Embryos develop autonomously under a predetermined schedule. While the genes involved in these processes have been charact...
Linking mitochondria metabolism, developmental timing, and human brain evolution
Linking mitochondria metabolism, developmental timing, and human brain evolution
Changes in developmental timing are an important factor of evolution in organ shape and function. This is particularly str...
New insights into how to induce and maintain embryonic diapause in the blastocyst
New insights into how to induce and maintain embryonic diapause in the blastocyst
Embryonic diapause in mammals is a period of developmental pause of the embryo at the blastocyst stage. During diapause, t...
Timing mechanisms: insights from comparative neural differentiation systems
Timing mechanisms: insights from comparative neural differentiation systems
Temporal control is central to deploy and coordinate genetic programs during development. At present, there is limited und...
Dynamic microenvironments shape nuclear organization and gene expression
Dynamic microenvironments shape nuclear organization and gene expression
Transcription is regulated at the molecular scale by highly dynamic events, including the binding of transcription factors...
RNA in chromatin organization and nuclear architecture
RNA in chromatin organization and nuclear architecture
Chromatin is surrounded by various types of nuclear bodies, including the nucleolus, Cajal bodies, paraspeckles, and nucle...
Epigenetic priming in the male germline
Epigenetic priming in the male germline
The germline is the only cellular lineage capable of transmitting genetic and epigenetic information to the next generatio...
Mechanistic drivers of chromatin organization into compartments
Mechanistic drivers of chromatin organization into compartments
The human genome is not just a simple string of DNA, it is a complex and dynamic entity intricately folded within the cell...
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Attraction and disruption: how loop extrusion and compartmentalisation shape the nuclear genome
Chromatin loops, which bring two distal loci of the same chromosome into close physical proximity, are the ubiquitous unit...
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation
Spatial orchestration of the genome: topological reorganisation during X-chromosome inactivation
Genomes are organised through hierarchical structures, ranging from local kilobase-scale cis-regulatory contacts to large ...
RNA editing and immune control: from mechanism to therapy
RNA editing and immune control: from mechanism to therapy
Adenosine-to-inosine (A-to-I) RNA editing is among the most prevalent RNA modifications in metazoans, catalyzed by enzymes...
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development
Topical section: embryonic models (2023) for Current Opinion in Genetics & Development
In recent years, modeling embryo development with stem cells has opened up new avenues in developmental biology. By recons...
Human blastoid as an in vitro model of human blastocysts
Human blastoid as an in vitro model of human blastocysts
Human development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often...
‘Enhancing’ skeletal muscle and stem cells in three-dimensions: genome regulation of skeletal muscle in development and disease
‘Enhancing’ skeletal muscle and stem cells in three-dimensions: genome regulation of skeletal muscle in development and disease
Skeletal muscle (SkM) is one of the most plastic tissues in the human body with an amazing ability to adapt to imposed dem...
Modifying gastruloids to dissect mechanisms of tissue-specific induction
Modifying gastruloids to dissect mechanisms of tissue-specific induction
How functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understand...
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Our understanding of somatic mutations and their connection to the aging process has seen significant advancements over th...
‘Enhancing’ skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
‘Enhancing’ skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Skeletal muscle (SkM) is one of the most plastic tissues in the human body with an amazing ability to adapt to imposed dem...
Editorial overview: Conflicts, conflicts everywhere
Editorial overview: Conflicts, conflicts everywhere
Harmit Malik obtained his Ph.D. from the Department of Biology at the University of Rochester (Rochester, NY) under the me...
Divergent outcomes of genetic conflict on the UV sex chromosomes of Marchantia polymorpha and Ceratodon purpureus
Divergent outcomes of genetic conflict on the UV sex chromosomes of Marchantia polymorpha and Ceratodon purpureus
Many eukaryotes have separate female and male individuals. In such species, one genome must implement two distinct develop...
Insights and applications of direct neuronal reprogramming
Insights and applications of direct neuronal reprogramming
Cell fate is determined through a coordinated activity of transcription factors (TFs) and chromatin-remodeling complexes t...
Overcoming muscle stem cell aging
Overcoming muscle stem cell aging
Volume 83, December 2023, 102127Author links open overlay panel, Reduced muscle strength and mass is one of the hallmarks ...
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