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Chromatin structure and dynamics: one nucleosome at a time
Chromatin structure and dynamics: one nucleosome at a time
Eukaryotic genomes store information on many levels, including their linear DNA sequence, the posttranslational modificati...
Dynamic chromosome association with nuclear organelles in living cells
Dynamic chromosome association with nuclear organelles in living cells
The development of progressively sophisticated tools complemented by the integration of live cell imaging enhances our und...
Allele-level visualization of transcription and chromatin by high-throughput imaging
Allele-level visualization of transcription and chromatin by high-throughput imaging
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with im...
From feulgen to modern methods: marking a century of DNA imaging advances
From feulgen to modern methods: marking a century of DNA imaging advances
The mystery of how human DNA is compactly packaged into a nucleus—a space a hundred thousand times smaller—whi...
Imaging extrachromosomal DNA (ecDNA) in cancer
Imaging extrachromosomal DNA (ecDNA) in cancer
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of on...
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells. It is primarily involved in the b...
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. M...
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Mast cells (MCs) in rat airways have been classified into two subtypes: epithelial MCs and connective tissue MCs (CTMCs). ...
FOXM1 requires IDH1 for late genes expression in mitotic cells
FOXM1 requires IDH1 for late genes expression in mitotic cells
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to α-ketoglutarate in cells. However...
Establishment of a 3D organoid culture model for the investigation of adult slow-cycling putative intestinal stem cells
Establishment of a 3D organoid culture model for the investigation of adult slow-cycling putative intestinal stem cells
The study of intestinal stem cells is a prerequisite for the development of therapies aimed at regenerating the gut. To en...
Distribution and morphologic characterization of telocytes in rat ovary and uterus: insights from ultrastructural and immunohistochemical analysis
Distribution and morphologic characterization of telocytes in rat ovary and uterus: insights from ultrastructural and immunohistochemical analysis
Telocytes (TCs) are characterized by a small oval-shaped cell body with long prolongations that are called telopods (Tps)....
Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis
Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis
Genes encoding Toll-like receptors (TLRs) are expressed by germ cells in the mouse testis. Nevertheless, the expression of...
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase–anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase–anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte
Oocyte meiotic maturation failure and chromosome abnormality is one of the main causes of infertility, abortion, and disea...
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
We recently reported that phogrin, also known as IA-2β or PTPRN2, forms a complex with the insulin receptor in pancre...
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c...
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Key reproductive events such as fertilization and early embryonic development occur in the lumen of the oviduct. Since inv...
Optimization of PAS stain and similar Schiff’s based methods for glycogen demonstration in liver tissue
Optimization of PAS stain and similar Schiff’s based methods for glycogen demonstration in liver tissue
Demonstration of glycogen in tissue holds considerable diagnostic relevance across various pathological conditions, partic...
JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes
JNK inhibition enhances cell–cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes
c-Jun NH2-terminal protein kinase (JNK) and p38 are stress-activated mitogen-activated protein kinases (MAPK) that are pho...
Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway
The third most prevalent malignancy to cause mortality is hepatocellular carcinoma (HCC). The Hedgehog (Hh) signaling path...
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy, tumor heterogeneity remains a formi...
The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury
The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury
Su (var) 3–9, enhancer of seste, trithorax (SET)-domain bifurcated histone lysine methyltransferase (SETDB1) plays a...
Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h
Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h
Proteins can be successfully localized in post-mortem (PM) brain tissue sections if the time until PM tissue sampling is n...
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry
Characterization of inflammation in chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) is an ongoing r...
Inhibition of Notch3/Hey1 ameliorates peribiliary hypoxia by preventing hypertrophic hepatic arteriopathy in biliary atresia progression
Inhibition of Notch3/Hey1 ameliorates peribiliary hypoxia by preventing hypertrophic hepatic arteriopathy in biliary atresia progression
Emerging evidence indicates the presence of vascular abnormalities and ischemia in bil...
Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons
The unique properties of superparamagnetic iron oxide nanoparticles (SPIONs) enable their use as magnetic biosensors, targ...
Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways
Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways
Cancer growth is a molecular mechanism initiated by genetic and epigenetic modifications that are involved in cell prolife...
Placental progesterone and its receptor in HIV-infected pre-eclamptic women
Placental progesterone and its receptor in HIV-infected pre-eclamptic women
Given the high prevalence of HIV infection and pre-eclampsia (PE) in South Africa, this study evaluated and compared the p...
Editorial: Histochemistry and Cell Biology implements new submission guidelines for image presentation and image analysis
Editorial: Histochemistry and Cell Biology implements new submission guidelines for image presentation and image analysis
Journal “Instructions for authors” typically describe in more or less detail how manuscript figures should be prepared for...
Local fractal dimension of collagen detects increased spatial complexity in fibrosis
Local fractal dimension of collagen detects increased spatial complexity in fibrosis
Increase of collagen content and reorganization characterizes fibrosis but quantifying the latter remains challenging. Spa...
Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life
Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life
Cell death is an essential process that occurs during the development of the central nervous system. Despite the availabil...
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