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HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway
HOXC10 promotes hypertrophic scar fibroblast fibrosis through the regulation of STMN2 and the TGF-β/Smad signaling pathway
The pathophysiology of hypertrophic scar (HS) shares similarities with cancer. HOXC10, a gene significantly involved in ca...
Complex shape markers can detect alterations in the spatial distribution of cell nuclei in human lung squamous cell carcinoma: a useful tool for automatic analysis?
Complex shape markers can detect alterations in the spatial distribution of cell nuclei in human lung squamous cell carcinoma: a useful tool for automatic analysis?
Lung cancer is the leading cause of cancer-related death. The use of computational methods to quantify changes that are no...
Novel role of curcumin as inhibitor of β-amyloid-induced lamin fragmentation
Novel role of curcumin as inhibitor of β-amyloid-induced lamin fragmentation
Oligomer amyloid beta 42 (Aβ) is considered the key pathogenic molecule in Alzheimer disease (AD) and causes specific...
Anaplastic thyroid carcinoma: vimentin segregates at the invasive front of tumors in a murine xenograft model
Anaplastic thyroid carcinoma: vimentin segregates at the invasive front of tumors in a murine xenograft model
Anaplastic thyroid carcinoma (ATC) ranks among the most lethal human cancers. Increased migratory and invasive capabilitie...
The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study
The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study
Peripheral nerve injuries are commonly encountered in clinical practice. Peripheral nerve injuries most commonly result in...
Mechanisms of S-phase arrest and mitochondrial dysfunction in complex III by DHODH inhibitors in tumorigenic TNBC cells
Mechanisms of S-phase arrest and mitochondrial dysfunction in complex III by DHODH inhibitors in tumorigenic TNBC cells
Dihydroorotate dehydrogenase (DHODH) inhibitors have recently gained increasing research interest owing to their potential...
Distribution and volume of mitochondria in alveolar epithelial type 1 cells in infant and adult human lungs
Distribution and volume of mitochondria in alveolar epithelial type 1 cells in infant and adult human lungs
Alveolar epithelial type I (AE1) cells with their wide spatial expansion form approximately 95% of the outer surface area ...
Characterization of primary cilia in different epithelial cells of thyroid gland
Characterization of primary cilia in different epithelial cells of thyroid gland
The primary cilium (PC) is a biosensor with diverse functions, depending on cellular type. In the thyroid, where it was fi...
Identification and culture of functional salivary gland ductal epithelial cells
Identification and culture of functional salivary gland ductal epithelial cells
Sialadenitis is a prevalent salivary gland disease resulting in decreased salivary flow rate. To date, little is known abo...
Expression of mRNA for molecules that regulate angiogenesis, endothelial cell survival, and vascular permeability is altered in endothelial cells isolated from db/db mouse hearts
Expression of mRNA for molecules that regulate angiogenesis, endothelial cell survival, and vascular permeability is altered in endothelial cells isolated from db/db mouse hearts
Metabolic syndrome (MetS) is a condition that includes symptoms, such as obesity, hyperglycemia, and hypertension, which e...
Anti-inflammatory and glial response maintain normal colon function in trimethyltin-treated rats
Anti-inflammatory and glial response maintain normal colon function in trimethyltin-treated rats
Studies on the contribution of enteric neuropathy and intestinal homeostasis to central nervous system degeneration using ...
Specificity of widely used lectins as probed with oligosaccharide and plant polysaccharide arrays
Specificity of widely used lectins as probed with oligosaccharide and plant polysaccharide arrays
Glycan-binding specificity was studied for Jacalin, RCA 120, SBA, PHA-L, PHA-E, WGA, UEA, AAL, LTL, LEL, SNA, DSA, LCA, MA...
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
The use of cold formalin fixation (CFF; i.e., fixating tissue samples with 4 °C precooled formalin) recently...
Expression of SARS-CoV-2 entry molecules ACE2, NRP1, TMPRSS2, and FURIN in the reproductive tissues of male macaques
Expression of SARS-CoV-2 entry molecules ACE2, NRP1, TMPRSS2, and FURIN in the reproductive tissues of male macaques
Coronavirus disease 2019 (COVID-19) reportedly affects male reproductive function by causing spermatogenesis dysfunction a...
Chromatin structure and dynamics: one nucleosome at a time
Chromatin structure and dynamics: one nucleosome at a time
Eukaryotic genomes store information on many levels, including their linear DNA sequence, the posttranslational modificati...
Dynamic chromosome association with nuclear organelles in living cells
Dynamic chromosome association with nuclear organelles in living cells
The development of progressively sophisticated tools complemented by the integration of live cell imaging enhances our und...
Allele-level visualization of transcription and chromatin by high-throughput imaging
Allele-level visualization of transcription and chromatin by high-throughput imaging
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with im...
From feulgen to modern methods: marking a century of DNA imaging advances
From feulgen to modern methods: marking a century of DNA imaging advances
The mystery of how human DNA is compactly packaged into a nucleus—a space a hundred thousand times smaller—whi...
Imaging extrachromosomal DNA (ecDNA) in cancer
Imaging extrachromosomal DNA (ecDNA) in cancer
Extrachromosomal DNA (ecDNA) are circular regions of DNA that are found in many cancers. They are an important means of on...
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells. It is primarily involved in the b...
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. M...
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Immunohistochemical analysis and distribution of epithelial mast cells in the rat larynx and trachea
Mast cells (MCs) in rat airways have been classified into two subtypes: epithelial MCs and connective tissue MCs (CTMCs). ...
FOXM1 requires IDH1 for late genes expression in mitotic cells
FOXM1 requires IDH1 for late genes expression in mitotic cells
Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to α-ketoglutarate in cells. However...
Establishment of a 3D organoid culture model for the investigation of adult slow-cycling putative intestinal stem cells
Establishment of a 3D organoid culture model for the investigation of adult slow-cycling putative intestinal stem cells
The study of intestinal stem cells is a prerequisite for the development of therapies aimed at regenerating the gut. To en...
Distribution and morphologic characterization of telocytes in rat ovary and uterus: insights from ultrastructural and immunohistochemical analysis
Distribution and morphologic characterization of telocytes in rat ovary and uterus: insights from ultrastructural and immunohistochemical analysis
Telocytes (TCs) are characterized by a small oval-shaped cell body with long prolongations that are called telopods (Tps)....
Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis
Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis
Genes encoding Toll-like receptors (TLRs) are expressed by germ cells in the mouse testis. Nevertheless, the expression of...
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase–anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte
MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase–anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte
Oocyte meiotic maturation failure and chromosome abnormality is one of the main causes of infertility, abortion, and disea...
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene
We recently reported that phogrin, also known as IA-2β or PTPRN2, forms a complex with the insulin receptor in pancre...
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
MOTS-c regulates pancreatic alpha and beta cell functions in vitro
The aim of this study is to determine the influence of the mitochondrial open-reading-frame of the twelve S rRNA-c (MOTS-c...
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
Key reproductive events such as fertilization and early embryonic development occur in the lumen of the oviduct. Since inv...
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