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Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy
RAG2 deficiency is characterized by a lack of B and T lymphocytes, causing severe lethal infections. Currently, RAG2 defic...
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification
Glioblastoma (GBM) is the most aggressive form of glioma, characterized by high mortality and poor prognosis. Dysregulatio...
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells
Adiponectin (APN), a vasoactive cytokine produced by adipocytes, has emerged as a critical player in retinal diseases. Ren...
Emodin regulated lactate metabolism by inhibiting MCT1 to delay non-small cell lung cancer progression
Emodin regulated lactate metabolism by inhibiting MCT1 to delay non-small cell lung cancer progression
Lung cancer is one of the most common malignant tumors in the world, with high incidence rate and mortality. Monocarboxyla...
Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1
Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1
The methods available for treating metastatic Ewing sarcoma (ES) are inadequate; thus, innovative therapeutic approaches n...
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma
Synovial sarcoma (SS) is identified as a sarcoma with monomorphic blue spindle cells that display variable epithelial diff...
Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells
Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells
As periodontal progenitor cells, human dental follicle stem cells (hDFCs) play an important role in regenerative medicine ...
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators
Baur R, Gertsch J, Sigel E. Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action ...
Osteoarthritis rat serum-derived extracellular vesicles aggravate osteoarthritis development by inducing NLRP3-mediated pyroptotic cell death and cellular inflammation
Osteoarthritis rat serum-derived extracellular vesicles aggravate osteoarthritis development by inducing NLRP3-mediated pyroptotic cell death and cellular inflammation
Osteoarthritis (OA), degenerative joint disease, is the most prevalent form of arthritis worldwide. Besides its substantia...
Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis
Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis
Oral bacteria naturally secrete extracellular vesicles (EVs), which have attracted attention for their promising biomedica...
Sequencing-based study of neural induction of human dental pulp stem cells
Sequencing-based study of neural induction of human dental pulp stem cells
Techniques for triggering neural differentiation of embryonic and induced pluripotent stem cells into neural stem cells an...
Apelin-13 alleviates intrauterine adhesion by inhibiting epithelial–mesenchymal transition of endometrial epithelial cells and promoting angiogenesis
Apelin-13 alleviates intrauterine adhesion by inhibiting epithelial–mesenchymal transition of endometrial epithelial cells and promoting angiogenesis
Intrauterine adhesion (IUA) is a common complication of surgical manipulation of the uterine cavity such as abortion. The ...
Establishment and characterization of two novel patient-derived cell lines from myxofibrosarcoma: NCC-MFS7-C1 and NCC-MFS8-C1
Establishment and characterization of two novel patient-derived cell lines from myxofibrosarcoma: NCC-MFS7-C1 and NCC-MFS8-C1
Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, presents a significant challenge because of its high recurrence...
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Transcription repression of estrogen receptor alpha by ghrelin/Gq/11/YAP signaling in granulosa cells promotes polycystic ovary syndrome
Polycystic ovarian syndrome (PCOS) is a prevalent endocrinological disorder affected by ghrelin. This study aimed to inves...
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer
Chronic systemic inflammation caused by diseases such as ulcerative colitis (UC) and Crohn’s disease (CD) increases ...
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Inhibition of the AP-1/TFPI2 axis contributes to alleviating cerebral ischemia/reperfusion injury by improving blood–brain barrier integrity
Reperfusion after cerebral ischemia leads to secondary damage to the nervous system, called cerebral ischemia/reperfusion ...
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
The role of monoglyceride lipase gene in promoting proliferation, metastasis, and free fatty acid accumulation in uveal melanoma cells
Uveal melanoma is a malignant tumor originating from melanocytes in the eye's uvea, often detected during routine opht...
Establishment and drug resistance characterization of paired organoids using human primary colorectal cancer and matched tumor deposit specimens
Establishment and drug resistance characterization of paired organoids using human primary colorectal cancer and matched tumor deposit specimens
Tumor deposits (TDs) represent a specific form tumor metastasis observed in colorectal cancer (CRC). The lack of successfu...
Pathophysiology, molecular mechanisms, and genetics of atrial fibrillation
Pathophysiology, molecular mechanisms, and genetics of atrial fibrillation
The development of atrial fibrillation (AF) is a highly complex, multifactorial process involving pathophysiologic mechani...
Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells
Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells
Authors and AffiliationsDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Sait...
Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Among mucus-producing lung cancers, invasive mucinous adenocarcinoma of the lung is a rare and unique subtype of pulmonary...
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA
Establishment of a human ovarian clear cell carcinoma cell line mutant in PIK3CB but not PIK3CA
A human ovarian clear cell carcinoma cell line was established from a 46-year-old Japanese woman. That line, designated MT...
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
A xenotransplantable malignant deciduoid mesothelioma-cell line, D-Meso-Sonobe
Conflict of interest The authors declare no conflicts of in...
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction
Acute coronary artery blockage leads to acute myocardial infarction (AMI). Cardiomyocytes are terminally differentiated ce...
Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Single-cell sequencing advances in research on mesenchymal stem/stromal cells
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a multifunctional stem cell population cap...
Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
Human ATP-binding cassette transporter C11 (ABCC11) is a membrane protein exhibiting ATP-dependent transport activity for ...
PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis
PMAIP1 regulates autophagy in osteoblasts via the AMPK/mTOR pathway in osteoporosis
Osteoporosis (OP) is a highly prevalent disorder characterized by low bone mass that severely reduces patient quality of l...
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression
To explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasi...
Pathophysiological role of Na–Cl cotransporter in kidneys, blood pressure, and metabolism
Pathophysiological role of Na–Cl cotransporter in kidneys, blood pressure, and metabolism
The Na–Cl cotransporter (NCC) is a well-recognized regulator of ion transportation in the kidneys that facilitates N...
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a cyt...
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