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Towards interpretable Cryo-EM: disentangling latent spaces of molecular conformations
Towards interpretable Cryo-EM: disentangling latent spaces of molecular conformations
Molecules are essential building blocks of life and their different conformations (i.e., shapes) crucially determine the f...
Understanding the impact of in vitro transcription byproducts and contaminants
Understanding the impact of in vitro transcription byproducts and contaminants
The success of messenger (m)RNA-based vaccines against SARS-CoV-2 during the COVID-19 pandemic has led to rapid growth and...
Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin
Metabolomics highlights biochemical perturbations occurring in the kidney and liver of mice administered a human dose of colistin
Introduction: Colistin (CMS) is used for the curation of infections caused by multidrug-resistant bacteria. CMS is constra...
Inactive metallopeptidase homologs: the secret lives of pseudopeptidases
Inactive metallopeptidase homologs: the secret lives of pseudopeptidases
Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of perform...
Gestational diabetes mellitus: Impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine
Gestational diabetes mellitus: Impacts on fetal neurodevelopment, gut dysbiosis, and the promise of precision medicine
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting approximately 16.5% of pregnancies worldwide ...
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
Use of logit transformation within statistical analyses of experimental results obtained as proportions: example of method validation experiments and EQA in flow cytometry
In laboratory medicine, measurement results are often expressed as proportions of concentrations or counts. These proporti...
RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses in Caenorhabditis elegans
RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses in Caenorhabditis elegans
Environmental conditions experienced early in the life of an animal can result in gene expression changes later in its lif...
Bibliometric analysis on CRISPR/Cas: a potential Sherlock Holmes for disease detection
Bibliometric analysis on CRISPR/Cas: a potential Sherlock Holmes for disease detection
CRISPR has revolutionized illness detection by using precision gene editing to identify specific sequences in recent years...
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids
Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids
Introduction: Carnitine O-octanoyltransferase (CROT) is a well-established peroxisomal enzyme involved in liver fatty acid...
Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication
Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication
Extracellular vesicles (EVs) serve as messengers for intercellular communication, yet the precise mechanisms by which reci...
Editorial: When predictions meet experiments: the future of structure determination
Figuring out the “protein folding problem,” that is predicting protein structure from its amino acid sequence, has posed a...
Editorial: Intracellular trafficking and membrane dynamics in health and disease
Intracellular trafficking is a tightly regulated process of membrane dynamics that facilitates the exchange of cargos betw...
Causal associations among gut microbiota, 1400 plasma metabolites, and asthma: a two-sample Mendelian randomization study
Causal associations among gut microbiota, 1400 plasma metabolites, and asthma: a two-sample Mendelian randomization study
BackgroundEmerging evidence indicates a correlation between imbalances in intestinal microbiota and changes in plasma meta...
Lipidomics revealed alterations in glycerophospholipid metabolism in skin squamous cell carcinoma
Lipidomics revealed alterations in glycerophospholipid metabolism in skin squamous cell carcinoma
BackgroundSkin squamous cell carcinoma (SCC) is a prevalent malignancy, and dysregulated lipid metabolism has been implica...
Editorial: Non-coding RNAs as emerging players in the development, diagnosis, and treatment of cancer
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), small interfering RNAs (siRNAs), long non-coding RNAs (lncRNAs), a...
Corrigendum: CMTM6 as a candidate risk gene for cervical cancer: comprehensive bioinformatics study
Corrigendum: CMTM6 as a candidate risk gene for cervical cancer: comprehensive bioinformatics study
Xiaoting Huang1,2†Wei Liu1,2†Chunshan Liu1,2†Jijie Hu3Baiyao Wang1,2Anbang Ren1,2Xiaona Huang4Yawei Yuan1,2*Jinquan Liu1,2...
Corrigendum: Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme
In the published article, there was an error in the Funding statement. A Funding statement was not included. However, the ...
Cryo-electron microscopy in the study of virus entry and infection
Cryo-electron microscopy in the study of virus entry and infection
Viruses have been responsible for many epidemics and pandemics that have impacted human life globally. The COVID-19 pandem...
Saikosaponin A attenuates osteoclastogenesis and bone loss by inducing ferroptosis
Saikosaponin A attenuates osteoclastogenesis and bone loss by inducing ferroptosis
To alleviate bone loss, most current drugs target osteoclasts. Saikosaponin A (Ssa), a triterpene saponin derived from Bup...
The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response
The role of actin cytoskeleton CFL1 and ADF/cofilin superfamily in inflammatory response
Actin remodeling proteins are important in immune diseases and regulate cell cytoskeletal responses. These responses play ...
The association of TNF-alpha secretion and mtDNA copy number in CD14+ monocytes of patients with obesity and CHD
The association of TNF-alpha secretion and mtDNA copy number in CD14+ monocytes of patients with obesity and CHD
IntroductionMitochondrial dysfunction may be one of the causes of inflammatory activation of monocytes and macrophages, wh...
Editorial: Heparan sulfate-binding proteins in health and disease
Editorial: Heparan sulfate-binding proteins in health and disease
Professor Robert J. Linhardt, whose contributions have left an indelible mark. Recognized globally for his pioneering rese...
Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study
Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study
Background: Lipid metabolism disorders were observationally associated with chalazion, but the causality of the related ci...
An automatic diagnosis model of otitis media with high accuracy rate using transfer learning
An automatic diagnosis model of otitis media with high accuracy rate using transfer learning
Introduction: Chronic Suppurative Otitis Media (CSOM) and Middle Ear Cholesteatoma are two common chronic otitis media dis...
Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation
Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation
The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric can...
The underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma
The underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma
The consistent notion holds that hepatocellular carcinoma (HCC) initiation, progression, and clinical treatment failure tr...
Simple Scattering: Lipid nanoparticle structural data repository
Simple Scattering: Lipid nanoparticle structural data repository
Lipid nanoparticles (LNPs) are being intensively researched and developed to leverage their ability to safely and effectiv...
Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia
Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia
Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular m...
CyaA translocation across eukaryotic cell membranes
CyaA translocation across eukaryotic cell membranes
The adenylate cyclase (CyaA) toxin is a major virulence factor produced by Bordetella pertussis, the causative agent of wh...
Editorial: Advanced functional nanomaterials for diagnosis, bioimaging, drug delivery and therapeutics
Editorial: Advanced functional nanomaterials for diagnosis, bioimaging, drug delivery and therapeutics
In the healthcare domain, nanomaterials play a pivotal role in simultaneous disease detection and treatment, addressing co...
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