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Adaptive SELEX strategies against HCV core protein lead to the same aptamer
Author links open overlay panel, , , , , , Research highlights•Three DNA aptamers against HCV core protein were selected: ...
A simple method for generating light-induced clusters of transcription factors: effects on the nuclear distribution of OCT4 and on its interactions with chromatin
How cells achieve the complex task of regulating gene expression and switching between transcriptional programs have puzzl...
Structural insight into the conversion of DhNik1, a hybrid histidine kinase from Debaryomyces hansenii to a cytotoxic phosphatase conformation for novel antifungal agent
Group III hybrid histidine kinase (HHK3) is universally present in all pathogenic fungi and regulates various biological p...
Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) are key regulators of the G1-S phase transition in the cell cycle. In can...
Deep mutational scanning of an engineered high-affinity ligand of the polyA binding protein MLLE domain
The MLLE domain is a peptide-binding domain found in the poly (A) binding protein (PABP) and the ubiquitin protein E3 liga...
Structures of ΔD421 Truncated Tau Fibrils
In healthy brain, the intrinsically disordered protein tau functions to assemble and stabilize microtubules,1, 2 which reg...
Investigation of Domain Interaction in the Apolipoprotein E Isoforms by HDX-MS
Apolipoprotein E (apoE) is a major lipoprotein in the brain involved in Cholesterol transport and lipid metabolism.1, 2 Th...
Off-pathway oligomers of α-synuclein and Aβ inhibit secondary nucleation of α-synuclein amyloid fibrils
Journal of Molecular BiologyVolume 437, Issue 10, 15 May 2025, 169048Author links open overlay panel, Highlights•Amyloidog...
Structural Plasticity of Plasmodium falciparum Plasmepsin X to Accommodate Binding of Potent Macrocyclic Hydroxyethylamine Inhibitors
Plasmodium falciparum plasmepsin X (PMX) has become a target of choice for the development of new antimalarial drugs due t...
TamL is a Key Player of the Outer Membrane Homeostasis in Bacteroidota
In Proteobacteria, the outer membrane protein TamA and the inner membrane-anchored protein TamB form the Translocation and...
Consecutive Steps of Membrane Insertion of the Two-spanning MscL Protein by Insertase YidC
The YidC/Oxa1/Alb3 insertases are conserved in all domains of life,1, 2 playing crucial roles in the membrane protein biog...
Yeast Knowledge Graphs Database for Exploring Saccharomyces Cerevisiae and Schizosaccharomyces Pombe
Journal of Molecular BiologyVolume 437, Issue 10, 15 May 2025, 169072Author links open overlay panel, , , , Highlights•Gen...
DDX37 and DDX50 Maintain Genome Stability by Preventing Transcription-dependent R-loop Formation
R-loops consist of an RNA-DNA hybrid and a displaced single-stranded DNA strand that play a central role in several biolog...
A Dual-Selection System for Enhanced Efficiency and Fidelity of Circular RNA Overexpression
Circular RNAs (circRNAs) are essential regulators of cellular processes, but are challenging to study using traditional me...
Optimized Preparation of Segmentally Labeled RNAs for NMR Structure Determination
Journal of Molecular BiologyVolume 437, Issue 10, 15 May 2025, 169073Author links open overlay panel, , , , , , , , , , , ...
Impacts of D-aspartate on the Aggregation Kinetics and Structural Polymorphism of Amyloid β Peptide 1–42
Isomerization of L-Aspartate (L-Asp) into D-aspartate (D-Asp) is a spontaneous non-enzymatic reaction that has been used i...
Distinct Roles of SARS-CoV-2 N Protein and NFP in Host Cell Response Modulation
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has driven extensive resear...
The 2.3 Å Structure of A21, a Protein Component of the Conserved Poxvirus Entry-Fusion Complex
The poxviruses comprise a large family of enveloped double-stranded DNA viruses that infect many vertebrates and invertebr...
Deciphering the Language of Protein-DNA Interactions: A Deep Learning Approach Combining Contextual Embeddings and Multi-Scale Sequence Modeling
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Structure of Essential RNA Regulatory Elements in the West Nile Virus 3′-Terminal Stem Loop
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Modification of Regulatory Tyrosine Residues Biases Human Hsp90α in its Interactions with Cochaperones and Clients
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Bridging the Gap between Sequence and Structure Classifications of Proteins with AlphaFold Models
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Visualizing Viral RNA Packaging Signals in Action
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An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection
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Cotranscriptional Folding of a 5′ Stem-loop in the Escherichia coli tbpA Riboswitch at Single-nucleotide Resolution
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Structural Basis of Main Proteases of Coronavirus Bound to Bofutrelvir
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Species-specific model based on sequence and structural information for ubiquitination sites prediction
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Accurate Identification of Periplasmic Urea-binding Proteins by Structure- and Genome Context-assisted Functional Analysis
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Insights into Ligand-Mediated Activation of an Oligomeric Ring-Shaped Gene-Regulatory Protein from Solution- and Solid-State NMR
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Shigella Senses the Environmental Cue Leucine to Promote its Virulence Gene Expression in the Colon
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