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SwrA-mediated Multimerization of DegU and an Upstream Activation Sequence Enhance Flagellar Gene Expression in Bacillus subtilis
SwrA-mediated Multimerization of DegU and an Upstream Activation Sequence Enhance Flagellar Gene Expression in Bacillus subtilis
Ayushi Mishra: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, W...
Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions
Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions
Highly specialized cells, such as neurons and podocytes, have arborized morphologies that serve their specific functions. ...
Single-protein Diffusion in the Periplasm of Escherichia coli
Single-protein Diffusion in the Periplasm of Escherichia coli
The width of the periplasmic space of Gram-negative bacteria is only about 25–30 nm along the long axis of the cell, which...
Cryo-EM Analysis of the Effect of Seeding with Brain-derived Aβ Amyloid Fibrils
Cryo-EM Analysis of the Effect of Seeding with Brain-derived Aβ Amyloid Fibrils
Journal of Molecular BiologyVolume 436, Issue 4, 15 February 2024, 168422Author links open overlay panel, , , , , Highligh...
Structural Analysis of Membrane-associated Forms of Helicobacter pylori VacA Toxin
Structural Analysis of Membrane-associated Forms of Helicobacter pylori VacA Toxin
Pore-forming toxins are secreted by many bacterial species. These toxins can function to kill other bacteria or act as vir...
KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein–Protein Interactions to Promote Cancer Cell Survival
KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein–Protein Interactions to Promote Cancer Cell Survival
KeywordsADP-ribosylationalphafold2protein–protein interactionmacro-PARPregulation of expressionAbbreviationsCESCCervical s...
How Dedicated Ribosomes Translate a Leaderless mRNA
How Dedicated Ribosomes Translate a Leaderless mRNA
Translation of genetic information into protein represents one of the most fundamental processes of living organisms. Tran...
In vivo Validation of Hsp90 Trans-splicing in Giardia lamblia: Highlighting the Role of Cis-elements
In vivo Validation of Hsp90 Trans-splicing in Giardia lamblia: Highlighting the Role of Cis-elements
Giardia lamblia is a neglected protist parasite which causes more than 300 million diarrhoeal cases worldwide annually.1 I...
Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils
Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils
Journal of Molecular BiologyVolume 436, Issue 4, 15 February 2024, 168441Author links open overlay panel, , , , , , , , , ...
The Hydrophilic C-terminus of Yeast Plasma-membrane Na+/H+ Antiporters Impacts Their Ability to Transport K+
The Hydrophilic C-terminus of Yeast Plasma-membrane Na+/H+ Antiporters Impacts Their Ability to Transport K+
Cation/H+ antiporters (CPA/SLC9 family) are present in the cells of most organisms (from bacteria to humans).1 They are se...
Leucine Motifs Stabilize Residual Helical Structure in Disordered Proteins
Leucine Motifs Stabilize Residual Helical Structure in Disordered Proteins
Journal of Molecular BiologyVolume 436, Issue 4, 15 February 2024, 168444Author links open overlay panel, , , , , Highligh...
Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current
Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current
Amyloid plaques and neurofibrillary tangles formed from amyloid-β (Aβ) peptide and Tau protein are two hallmark lesions of...
NeuroPep 2.0: An Updated Database Dedicated to Neuropeptide and Its Receptor Annotations
NeuroPep 2.0: An Updated Database Dedicated to Neuropeptide and Its Receptor Annotations
Neuropeptides are typically 3–100 amino acids long linear polypeptide gene products synthesized as larger precursors that ...
Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant
Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant
Ubiquitin (Ub) is a post-translational modifier used in cellular signaling, protein degradation, immune response, and vari...
Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a transmembrane zinc metalloprotease that belongs to the M1 family...
A Practical Site-specific Method for the Detection of Bulky DNA Damages
A Practical Site-specific Method for the Detection of Bulky DNA Damages
DNA damages compromise genomic integrity and function. There are many types of DNA damages, ranging from chemical modifica...
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination
Phase Variation of Flagella and Toxins in Clostridioides difficile is Mediated by Selective Rho-dependent Termination
Clostridioides difficile is one of the most common causes of nosocomial infections.1, 2 C. difficile infection (CDI) is as...
Interference Requirements of Type III CRISPR-Cas Systems from Thermus thermophilus
Interference Requirements of Type III CRISPR-Cas Systems from Thermus thermophilus
KeywordsCas10-CsmCas10-CmrcrRNA-target complementarityCRISPR-associated nucleasesHD domainAbbreviationsCRISPRclustered reg...
Discovery of a trefoil knot in the RydC RNA: Challenging previous notions of RNA topology
Discovery of a trefoil knot in the RydC RNA: Challenging previous notions of RNA topology
Knots are very common in polymers, including DNA and protein molecules. Yet, no genuine knot has been identified in natura...
The Bacterial Proteasome Inter-domain Is a Selectivity Barrier for Degradation-tag Binding
The Bacterial Proteasome Inter-domain Is a Selectivity Barrier for Degradation-tag Binding
Intracellular proteolysis, a process that enables proteome remodeling, protein quality control, regulation of cellular pro...
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
G-quadruplexes (or “G4s”) are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. They are ...
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Keywordsmembrane protein topologyperiplasmfluorescenceTat protein transportEscherichia coliData availabilityCustom written...
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Journal of Molecular BiologyVolume 436, Issue 2, 15 January 2024, 168369Author links open overlay panel, , , , , , , , , H...
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
About one-third of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative a...
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Inteins are a unique class of proteins that are capable of self-excision from larger polypeptides by ligation of flanking ...
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Keywordsphase separationprion-likeDrosophila-behaviour human splicing proteinsDNA repairparaspeckleAbbreviationsCsatsatura...
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Transcription is the first step in gene regulation and is performed by RNA polymerase (RNAP). RNAP core enzyme that cataly...
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Salmonella enterica Serovar typhimurium infects 100,000 people annually and causes Salmonellosis, which can be potentially...
Characterizing Different Modes of Interplay Between Rap1 and H3 Using Inducible H3-depletion Yeast
Characterizing Different Modes of Interplay Between Rap1 and H3 Using Inducible H3-depletion Yeast
Keywordstranscription factorhistonechromatin immunoprecipitationRNA sequencingepigeneticsData availabilityRNA-seq and ChIP...
Emerging Trends in Cryo-EM-based Structural Studies of Neuropathological Amyloids
Emerging Trends in Cryo-EM-based Structural Studies of Neuropathological Amyloids
Amyloid fibrils are filamentous aggregates of misfolded proteins that, despite their diversity in sequence, embrace a char...
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