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The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks
The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks
The intestinal health of broilers is closely related to their overall health status, as the intestinal tract serves not on...
SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells
SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells
SAMHD1 (Sterile alpha motif domain and histidine/aspartic acid domain-containing protein1) is a dGTP-stimulated deoxynucle...
Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis
Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis
The condition of hypothyroidism is characterized by generalized hypometabolism caused by a decrease in thyroid hormone sec...
Predicting the risk of interstitial lung disease in patients with primary Sjögren's syndrome: Novel nomogram and elevated Th2 cells
Predicting the risk of interstitial lung disease in patients with primary Sjögren's syndrome: Novel nomogram and elevated Th2 cells
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterised by infiltration of lymphocyte (LYMP) into the sali...
Human beta defensin 3 knockdown inhibits the proliferation and migration of airway smooth muscle cells through regulating the PI3K/AKT signaling pathway
Human beta defensin 3 knockdown inhibits the proliferation and migration of airway smooth muscle cells through regulating the PI3K/AKT signaling pathway
Asthma is regarded as a common pulmonary disease among the pediatric population, and the incidence and mortality rates hav...
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5
Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5
Allergic rhinitis (AR) is a chronic inflammatory upper airway disease characterized by itchy nose, stuffy nose, paroxysmal...
Hydrogen ameliorates endotoxin-induced acute lung injury through AMPK-mediated bidirectional regulation of Caspase3
Hydrogen ameliorates endotoxin-induced acute lung injury through AMPK-mediated bidirectional regulation of Caspase3
Septic lung injury is characterized by uncontrollable inflammatory infiltrations and acute onset bilateral hypoxemia. Evid...
Exploring the molecular and immune-landscape of lung cancer associated with cystic airspaces
Exploring the molecular and immune-landscape of lung cancer associated with cystic airspaces
Although clinical rarity, there has been increasingly reports recently of a unique type of lung cancer characterized by th...
Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy
Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy
AbbreviationsGalNAcN-acetylgalactosamineSiRNAsmall interfering RNART-qPCRReal Time-quantitative PCRKeywordsGalNAc-siRNAcom...
Recent advances in potential targets for myocardial ischemia reperfusion injury: Role of macrophages
Recent advances in potential targets for myocardial ischemia reperfusion injury: Role of macrophages
AbbreviationsAMIacute myocardium infarctionAMPKAMP-activated protein kinaseBFGFbasic fibroblast growth factorCABGcoronary ...
Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner
Melatonin improves salivary gland damage and hypofunction in pSS by inhibiting IL-6/STAT3 signaling through its receptor-dependent manner
Primary Sjogren's syndrome (pSS) is a slowly progressing systemic autoimmune disorder characterized by lymphocytic infiltr...
MS4A6D Promotes carrageenan-induced footpad swelling in mice through enhancing macrophages-derived inflammation
MS4A6D Promotes carrageenan-induced footpad swelling in mice through enhancing macrophages-derived inflammation
Our previous work has demonstrated that the tetraspan MS4A6D interacts with MHC-II to be a complex that promotes macrophag...
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) affects an estimated 35–50% of the male population at some ...
CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration
CXCL1-CXCR2 axis mediates inflammatory response after sciatic nerve injury by regulating macrophage infiltration
Peripheral nerve injuries are clinically common, and the high regenerative capacity is a major advantage of peripheral ner...
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages
Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages
Systemic lupus erythematosus (SLE) is a complex autoimmune disease of unknown etiology. It is marked by the production of ...
Melanoma extracellular vesicles inhibit tumor growth and metastasis by stimulating CD8 T cells
Melanoma extracellular vesicles inhibit tumor growth and metastasis by stimulating CD8 T cells
Malignant melanoma is one of the most concerning malignant tumors because of its ability to spread early and aggressively....
Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells
Regulation of the STAT3 pathway by lupus susceptibility gene Pbx1 in T cells
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a genetic predisposition that results from the com...
Mosquito allergy: Immunological aspects and clinical management
Mosquito allergy: Immunological aspects and clinical management
Volume 164, December 2023, Pages 153-158Author links open overlay panel, , , AbstractMosquito allergy has been conceived a...
Immunomodulation by mesenchymal stem cells during osteogenic differentiation: Clinical implications during bone regeneration
Immunomodulation by mesenchymal stem cells during osteogenic differentiation: Clinical implications during bone regeneration
Bone is a complex connective tissue which constitutes the skeletal system of the body and is primarily involved in the str...
Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells
Role of HDAC6-STAT3 in immunomodulatory pathways in Colorectal cancer cells
Cancer initiation and progression is characterized by a series of deregulated mechanisms, by different phenomena such as i...
Silencing of STUB1 relieves osteoarthritis via inducing NRF2-mediated M2 macrophage polarization
Silencing of STUB1 relieves osteoarthritis via inducing NRF2-mediated M2 macrophage polarization
Osteoarthritis (OA) is a common degenerative joint disease characterized by progressive cartilage degradation, subchondral...
Molecular cloning of the hepcidin gene from crescent sweetlips (Plectorhinchus cinctus) and characterization of its encoded antimicrobial peptide
Molecular cloning of the hepcidin gene from crescent sweetlips (Plectorhinchus cinctus) and characterization of its encoded antimicrobial peptide
The innate immune system is essential for fish to survive in the aquatic environment with abundant microflora (Thirunavukk...
Identification and functional characterization of Caspase-9 in goldfish (Carassius auratus L.) in response to Aeromonas hydrophila infection
Identification and functional characterization of Caspase-9 in goldfish (Carassius auratus L.) in response to Aeromonas hydrophila infection
Goldfish is a widely used model organism for studying various fields such as endocrinology, toxicology, molecular biology,...
Corrigendum to “DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells” [Mol. Immunol. 131 (2021) 6222]
Corrigendum to “DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells” [Mol. Immunol. 131 (2021) 6222]
Volume 164, December 2023, Page 123Author links open overlay panelCan Li a, Weiwei Liu a, Fang Wang a, Toshihiko Hayashi a...
Interleukins-6 −174G/C (rs1800795) and −572C/G (rs1800796) polymorphisms and prostate cancer risk
Interleukins-6 −174G/C (rs1800795) and −572C/G (rs1800796) polymorphisms and prostate cancer risk
Prostate cancer (PCa) is a significant global health issue, ranked as the most prevalent non-cutaneous malignancy and the ...
Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410–3p
Catapol attenuates the aseptic inflammatory response to hepatic I/R injury in vivo and in vitro by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway via the microRNA-410–3p
AbbreviationsALTalanine aminotransferaseASTaspartate aminotransferase CAT, CatalpolHMGB1high-mobility group protein B1IL-1...
Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments
Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments
Scorpion sting envenoming is a global public health problem. However, there are geographical areas such as Latin America, ...
Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation
Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation
The pathophysiology of DFUs is relatively well studied, and growing evidence points towards the regulation of a key player...
Differential expression of interleukin-35 receptor distinguishes different subsets of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in a mouse endometriosis model
Differential expression of interleukin-35 receptor distinguishes different subsets of granulocyte-macrophage-colony-stimulating factor-producing T helper cells in a mouse endometriosis model
Endometriosis is caused by the presence of endometrial tissue outside the uterine cavity (Chapron et al., 2019). The immun...
A novel intergenic variant, rs2004339 A/G, of the gene encoding interleukin-40, C17orf99, is associated with risk of rheumatoid arthritis in Iraqi women
A novel intergenic variant, rs2004339 A/G, of the gene encoding interleukin-40, C17orf99, is associated with risk of rheumatoid arthritis in Iraqi women
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, characterized by chronic synovial hyperplasia associated ...
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