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Insights into the cytotoxicity of photoactivatable Ru(II) carbonyl complexes towards human liver carcinoma cells
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Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis
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Novel 1,2,4-triazole-derived Schiff base derivatives: Design, synthesis, and multi-enzyme targeting potential for therapeutic applications
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Novel furazanoazepines derivatives as SDH inhibitors: Design, synthesis and their fungicidal activities
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Dimethylallylated stilbenoids by chemo-selective prenyltransferases and their α-glucosidase inhibitory effects
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Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor
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Novel (−)-eigallocatechin-3-gallate-erlotinib conjugates via triazole rings inhibit non-small cell lung cancer cells through EGFR signaling pathway
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7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biological activity
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Design, synthesis and biological evaluation of new class of pyrazoles-dihydropyrimidinone derivatives as bone anabolic agents
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A novel PET tracer for noninvasive imaging the checkpoints expression of innate and adaptive immunity in tumors by simultaneously targeting CD24 and PD-L1
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Influence of component structural arrangement on cholesterol-antigen conjugate immunogenicity and antisera bactericidal activity against group A Streptococcus
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Dihydro-β-agarofuran sesquiterpenoids from the root bark of Tripterygium wilfordii and their anti-neuroinflammatory activities
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Decoding structural determinants of aryl hydrocarbon receptor antagonism by monoterpenoids
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Insights into curcumin’s anticancer activity in pancreatic ductal adenocarcinoma: Experimental and computational evidence targeting HRAS, CCND1, EGFR and AKT1
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Development of novel rivastigmine derivatives as selective BuChE inhibitors for the treatment of AD
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Novel carbazole-thiadiazole derivatives as α-amylase and α-glucosidase inhibitors: Design, biological evaluation, and computational insights
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Lipoic acid scaffold applications in the design of multitarget-directed ligands against Alzheimer’s disease
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Small-molecule BTK inhibitors: From discovery to clinical application
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Exploring 4-quinolone-3-carboxamide derivatives: A versatile framework for emerging biological applications
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Phosphate triester-based multifunctional handles for post-synthetic oligonucleotide functionalization
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Antidote-controlled DNA aptamer modulates human factor IXa activity
Antidote-controlled DNA aptamer modulates human factor IXa activity
Cardiovascular disease is the leading cause of death among urban and rural residents worldwide, and has become a major pub...
Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
Poly (ADP-ribose) polymerases (PARPs) are a group of enzymes that consist of 17 different members. They can be further cla...
Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors
Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors
RAS gene family (HRAS, NRAS and KRAS) have emerged as prominent oncogenes in human cancers. These mutations can activate s...
Design and one-pot synthesis of new substituted pyrrolo[1,2-a]thieno[3,2-e]pyrimidine as potential antitumor agents: in vitro and in vivo studies
Design and one-pot synthesis of new substituted pyrrolo[1,2-a]thieno[3,2-e]pyrimidine as potential antitumor agents: in vitro and in vivo studies
Chemistry of heterocyclic compounds is a significant contributor to the discovery and development of new drugs. Many pyrim...
Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum
Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum
The global incidence of end-stage heart failure (HF) is increasing, and a prominent challenge facing heart transplantation...
Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo
Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo
Cancer is the leading cause of death worldwide, and the signs of ovarian cancer, which usually manifest as bloating and ab...
Evaluation of anticancer activity of novel platinum(II) bis(thiosemicarbazone) complex against breast cancer
Evaluation of anticancer activity of novel platinum(II) bis(thiosemicarbazone) complex against breast cancer
Volume 148, July 2024, 107486Author links open overlay panel, , , , , , , , , Highlights•Bis(thiosemicarbazone) derivative...
Exploring the unexplored chemical space: Rational identification of new Tafenoquine analogs with antimalarial properties
Exploring the unexplored chemical space: Rational identification of new Tafenoquine analogs with antimalarial properties
Malaria is a life-threatening disease that caused an estimated 241 million cases and 627,000 related deaths in 2020 among ...
Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model
Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model
With its high rates of morbidity, depression is a debilitating mental disorder that poses a serious threat to human health...
Chemical sensors detect and resolve proteome aggregation in peripheral neuropathy cell model induced by chemotherapeutic agents
Chemical sensors detect and resolve proteome aggregation in peripheral neuropathy cell model induced by chemotherapeutic agents
Protein misfolding and aggregation represent hallmark features of numerous degenerative diseases [1]. When exposed to diff...
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