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Molecular and biological characterization of VEGF-mimetic peptidomimetic containing a morpholine β-amino acid
The QK peptide is a 15-residue VEGF-mimetic compound known for its proangiogenic activity. Its helical conformation plays ...
Probiotic-based derived exopolysaccharide-zinc oxide nanoparticles: a novel approach to colorectal cancer gene modulation
CRC has become one of the most common (third) types of cancer and remains one of the leading causes of cancer-related mort...
Histone deacetylase 6: a potential therapeutic target for drug development
Epigenetics refers to reversible and heritable mechanisms that alter gene expression without altering DNA sequence, includ...
A review: recent developments of co-targeted TRK (tropomyosin receptor kinases) inhibitors for cancer therapy
Cancer is a lethal and dangerous disease which affects millions of people's lives in the world. Based on the American Canc...
Exploring DPP-4: Implications in diverse diseases and structural insights for novel inhibitor design
Diabetes mellitus (DM) poses a significant public health challenge, impacting roughly 10 % of the population. Many countri...
Lipid-conjugated nucleoside prodrugs for antiviral therapy
Nucleoside and Nucleotide analogs, acting as antimetabolites or inhibitors that interfere with DNA or RNA synthesis, have ...
Overcoming resistance in RET-altered cancers through rational inhibitor design and combination therapies
Tyrosine kinases are enzymes that catalyze the transfer of phosphate groups from ATP to tyrosine residues on proteins with...
Porcupine (PORCN): structural insights, functional mechanisms, and therapeutic potential in Wnt-driven diseases
Porcupine (PORCN), an endoplasmic reticulum (ER)-resident membrane-bound O-acyltransferase (MBOAT) [1], regulates the Wnt ...
Discovery of natural compounds and their derivatives against neuroinflammation: Pharmacological mechanisms and structure-activity relationship
Neuroinflammation refers to the inflammatory response within the central nervous system mediated by immune and glial cells...
Targeted protein degradation in pancreatic cancer: advances and challenges of PROTAC-based therapeutics
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), remains one of the deadliest malignancies worldwi...
Integrating molecular imaging with near-infrared theranostics to improve early detection and therapy of Alzheimer's disease
Globally, Alzheimer's disease (AD) is the leading cause of dementia. It is a long-term neurological condition that impairs...
MAP4K3/GLK: Structure, molecular pharmacology and drug development
The serine/threonine kinase MAP4K3 (mitogen activated protein kinase kinase kinase kinase 3, also known as GLK, germinal-c...
Development of APOBEC3B inhibitors: Recent advances and perspectives
The apolipoprotein B mRNA editing catalytic polypeptide-like 3 (APOBEC3, A3) enzyme family is a class of cytosine deaminas...
A comprehensive review of targeting sterol 14α-demethylase and sterol C-24 methyl transferase, two pivotal proteins in Leishmania, as compelling therapeutic targets
Leishmaniasis, a group of protozoan parasitic infections, ranks among the top 10 neglected tropical diseases and is the se...
The role and potential therapeutic application of HDAC6 inhibitors in inflammation-related diseases: A medicinal chemistry perspective
Inflammation, a common pathological process, represents an acute response of the body to stimulus (infection, tissue damag...
Recent progress in topoisomerase inhibitors as anticancer agents: Research and design strategies for Topo I and II inhibitors via structural optimization
Cancer is increasingly recognized as a significant global health threat and ranks among the foremost causes of mortality [...
Unraveling the mechanisms of ubiquitin-specific proteases in hepatocellular carcinoma: A focus on inhibitors
Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide and ranks among the top ten most prevalent canc...
Design, synthesis, and biological evaluation of death-associated protein kinase 1 PROTACs
Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin-regulated serine/threonine kinase that plays a pivotal r...
Fluorescent Triazolyl unnatural amino acids in protein engineering: Encoding super folder green fluorescent protein and spectroscopic study
Over the years, the Genetic Code Expansion (GCE) strategy has allowed the precise incorporation of desired unnatural amino...
Natural diterpenoids isolated-interaction-phenotypic target characterization: An idea performed with Daphne genkwa and Wikstroemia chamaedaphne bud extract
The diterpenoids derived from Daphne genkwa (Thymelaeaceae) and Wikstroemia chamaedaphne (Thymelaeaceae) have been regarde...
Insights into the cytotoxicity of photoactivatable Ru(II) carbonyl complexes towards human liver carcinoma cells
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Functional characterization and regioselectivity manipulation of two Benzylisoquinoline alkaloids O-methyltransferases from Stephania yunnanensis
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Novel 1,2,4-triazole-derived Schiff base derivatives: Design, synthesis, and multi-enzyme targeting potential for therapeutic applications
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Novel furazanoazepines derivatives as SDH inhibitors: Design, synthesis and their fungicidal activities
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Dimethylallylated stilbenoids by chemo-selective prenyltransferases and their α-glucosidase inhibitory effects
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Design, synthesis and biological evaluation of a novel non-Gemini analog of UVB1 and crystal structure of its complex with the vitamin D receptor
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Novel (−)-eigallocatechin-3-gallate-erlotinib conjugates via triazole rings inhibit non-small cell lung cancer cells through EGFR signaling pathway
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7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biological activity
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Design, synthesis and biological evaluation of new class of pyrazoles-dihydropyrimidinone derivatives as bone anabolic agents
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A novel PET tracer for noninvasive imaging the checkpoints expression of innate and adaptive immunity in tumors by simultaneously targeting CD24 and PD-L1
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