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Antidote-controlled DNA aptamer modulates human factor IXa activity
Antidote-controlled DNA aptamer modulates human factor IXa activity
Cardiovascular disease is the leading cause of death among urban and rural residents worldwide, and has become a major pub...
Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
Poly (ADP-ribose) polymerases (PARPs) are a group of enzymes that consist of 17 different members. They can be further cla...
Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors
Discovery, optimization and biological activity evaluation of genipin derivatives as potential KRAS G12D inhibitors
RAS gene family (HRAS, NRAS and KRAS) have emerged as prominent oncogenes in human cancers. These mutations can activate s...
Design and one-pot synthesis of new substituted pyrrolo[1,2-a]thieno[3,2-e]pyrimidine as potential antitumor agents: in vitro and in vivo studies
Design and one-pot synthesis of new substituted pyrrolo[1,2-a]thieno[3,2-e]pyrimidine as potential antitumor agents: in vitro and in vivo studies
Chemistry of heterocyclic compounds is a significant contributor to the discovery and development of new drugs. Many pyrim...
Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum
Discovery of novel natural cardiomyocyte protectants from a toxigenic fungus Stachybotrys chartarum
The global incidence of end-stage heart failure (HF) is increasing, and a prominent challenge facing heart transplantation...
Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo
Brunonianines D-F, three new C19-diterpenoid alkaloids from the Delphinium brunonianum, with therapeutic effect on ovarian cancer in vitro and in vivo
Cancer is the leading cause of death worldwide, and the signs of ovarian cancer, which usually manifest as bloating and ab...
Evaluation of anticancer activity of novel platinum(II) bis(thiosemicarbazone) complex against breast cancer
Evaluation of anticancer activity of novel platinum(II) bis(thiosemicarbazone) complex against breast cancer
Volume 148, July 2024, 107486Author links open overlay panel, , , , , , , , , Highlights•Bis(thiosemicarbazone) derivative...
Exploring the unexplored chemical space: Rational identification of new Tafenoquine analogs with antimalarial properties
Exploring the unexplored chemical space: Rational identification of new Tafenoquine analogs with antimalarial properties
Malaria is a life-threatening disease that caused an estimated 241 million cases and 627,000 related deaths in 2020 among ...
Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model
Golgi-targeted NIR fluorescent probe with large stokes shift for real-time monitoring of nitric oxide in depression model
With its high rates of morbidity, depression is a debilitating mental disorder that poses a serious threat to human health...
Chemical sensors detect and resolve proteome aggregation in peripheral neuropathy cell model induced by chemotherapeutic agents
Chemical sensors detect and resolve proteome aggregation in peripheral neuropathy cell model induced by chemotherapeutic agents
Protein misfolding and aggregation represent hallmark features of numerous degenerative diseases [1]. When exposed to diff...
Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury
Design and synthesis of sulfonamide phenothiazine derivatives as novel ferroptosis inhibitors and their therapeutic effects in spinal cord injury
Spinal cord injury (SCI) is a serious traumatic neurological injury disease that occurs primarily as a result of car accid...
Molecular design, construction and analgesic mechanism insights into the novel transdermal fusion peptide ANTP-BgNPB
Molecular design, construction and analgesic mechanism insights into the novel transdermal fusion peptide ANTP-BgNPB
Chronic pain resulting from nerve injury, inflammation, or cancer infiltration poses a significant health challenge. Despi...
Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors
Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors
Currently, surgery, radiotherapy, and chemotherapy are still the three major traditional methods for treating cancer world...
Design, synthesis, and biological evaluation of 2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis
Design, synthesis, and biological evaluation of 2-(2-oxoindolin-3-ylidene)hydrazinecarbothioamides as a potential EGR-1 inhibitor for targeted therapy of atopic dermatitis
Atopic dermatitis (AD) or atopic eczema is one of the most prevalent inflammatory skin diseases worldwide. The Global Burd...
Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson’s disease
Identification and optimization of nitrophenolic analogues as dopamine metabolic enzyme inhibitors for the treatment of Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that manifests clinically through motor symptoms like resting tre...
Blocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile
Blocking potential metabolic sites on NAT to improve its safety profile while retaining the pharmacological profile
Opioid crisis has become a significant problem in the United States, with over 3 million residents having suffered from op...
Novel BODIPY-based nano-biomaterials with enhanced D-A-D structure for NIR-triggered photodynamic and photothermal therapy
Novel BODIPY-based nano-biomaterials with enhanced D-A-D structure for NIR-triggered photodynamic and photothermal therapy
Photoinduced cancer therapy, a light-based therapeutic intervention, has attracted vast attention of numerous researchers ...
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors
Acquired Immunodeficiency Syndrome (AIDS) is a malignant infectious disease caused by the Human Immunodeficiency Virus (HI...
Antimicrobial activity and structure–activity relationships of molecules containing mono- or di- or oligosaccharides: An update
Antimicrobial activity and structure–activity relationships of molecules containing mono- or di- or oligosaccharides: An update
Bacterial infection, one of the most common human diseases, which is caused by disrupting the normal coexistence of microo...
A review of chemical signaling mechanisms underlying quorum sensing and its inhibition in Staphylococcus aureus
A review of chemical signaling mechanisms underlying quorum sensing and its inhibition in Staphylococcus aureus
Staphylococcus aureus is a prominent worldwide infectious agent that leads to a significant and complicated in assessing t...
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Uric acid (UA) is an organic heterocyclic compound with molecular formula of C5H4N4O3. UA is biosynthesized in the liver a...
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Malaria has been derived from an Italian word i.e., ‘mal’ ‘area’ which describes ‘bad air’ as the disease is said to be ea...
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
Musashi is a very famous samurai in Japanese culture, but the term has a disparate meaning in biology. In 1994, Craig Mont...
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Autophagy, ubiquitous in eukaryotic cells (from yeast to mammals), is an antioxidant response mechanism in cells under oxi...
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Cancer is an increasingly severe health issue that affects individuals of all ages. In 2022, it was estimated that there w...
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Design of tubulin inhibitors as anticancer drugs dynamically developed over the past 20 years. The modern arsenal of poten...
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Cancer is one of the deadliest diseases that is spreading across the world [1]. Nearly 10 million deaths were reported fro...
Biological activity and structural modification of isosteviol over the past 15 years
Biological activity and structural modification of isosteviol over the past 15 years
Natural products are significant sources of lead compounds and functional organic molecules used in pharmaceuticals. Scree...
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
Because of their widespread distribution in natural products and synthesized compounds with potential bioactivities, spiro...
Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation
Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation
Natural products from plants and microorganisms play a pivotal role in modern medicine and show a wide range of pharmacolo...
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