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Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Glucagon and glucagon-like peptide-1 (GLP-1) are derived from the same precursor; proglucagon, and dual agonists of their ...
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make dis...
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, ...
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
The aim of the study is to describe the time trend of type 2 diabetes incidence in the largest state of Germany, Bavaria, ...
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is assoc...
Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort
Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort
Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence ...
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes
A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction o...
Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
As a result of early loss of the glucagon response, adrenaline is the primary counter-regulatory hormone in type 1 diabete...
Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have sh...
Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
The aim of this study was to examine the dose–response associations of device-measured physical activity types and p...
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be ...
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation th...
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Alt...
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokine would lead to antige...
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium su...
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Monogenic diabetes is estimated to account for 1–6% of paediatric diabetes cases in primarily non-consanguineous pop...
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Current management of chronic kidney disease (CKD) in type 1 diabetes centres on glycaemic control, renin–angiotensi...
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Authors’ relationships and activities The authors declare that there are n...
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Augustana Faculty, University of Alberta, Camrose, AB, CanadaJane E. YardleyAlberta Diabetes Institute, University of Albe...
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Glucagon-expressing pancreatic alpha cells have attracted much attention for their plasticity to transdifferentiate into i...
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
While the risk factors for diabetic peripheral neuropathy (DPN) are now well recognised, the risk factors for painful DPN ...
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Effect of maternal low protein diet on the expression of insulin signalling molecules in epididymal WAT of 14-month-old ma...
Multi-omic prediction of incident type 2 diabetes
Multi-omic prediction of incident type 2 diabetes
The identification of people who are at high risk of developing type 2 diabetes is a key part of population-level preventi...
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signatu...
Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes
Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes
The aim of this work was to define a unique remission status using glycaemia risk index (GRI) and other continuous glucose...
Associations between type 1 diabetes and educational outcomes: an Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure
Associations between type 1 diabetes and educational outcomes: an Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure
Type 1 diabetes is one of the most common chronic diseases of childhood. It is hypothesised that the metabolic and psychos...
The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
Diets with higher inflammatory and insulinaemic potential have been associated with an increased risk of type 2 diabetes. ...
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Inflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprote...
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