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Identifying novel biomarkers for ankylosing spondylitis through proteomic profiling of serum-derived extracellular vesicles
Identifying novel biomarkers for ankylosing spondylitis through proteomic profiling of serum-derived extracellular vesicles
The objective of this study is to analyze the protein composition of extracellular vesicles (EVs) isolated from the serum ...
Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis
Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation, synovial hyperp...
Antitumor effects of human antithymocyte globulin on peripheral T cell lymphoma via complement-dependent and -independent cytotoxicity in xenograft mouse models
Antitumor effects of human antithymocyte globulin on peripheral T cell lymphoma via complement-dependent and -independent cytotoxicity in xenograft mouse models
Peripheral T cell lymphomas (PTCL) is a group of non-Hodgkin lymphomas characterized by substantial molecular heterogeneit...
Potential therapeutic roles of natural killer cells in acute myeloid leukemia: a systematic review study
Potential therapeutic roles of natural killer cells in acute myeloid leukemia: a systematic review study
Acute myeloid leukemia (AML) is a blood cancer caused by genetic mutations in hematopoietic precursor cells, leading to ab...
CCL22 as a diagnostic and prognostic biomarker for pediatric-onset systemic lupus erythematosus
CCL22 as a diagnostic and prognostic biomarker for pediatric-onset systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by diverse symptoms and multisystem involvement....
Applications of CRISPR-Cas9 in mitigating cellular senescence and age-related disease progression
Applications of CRISPR-Cas9 in mitigating cellular senescence and age-related disease progression
Aging is a multifaceted process influenced by many elements. During cell division, the repetitive DNA sequences at the end...
Rationale of using immune checkpoint inhibitors (ICIs) and anti-angiogenic agents in cancer treatment from a molecular perspective
Rationale of using immune checkpoint inhibitors (ICIs) and anti-angiogenic agents in cancer treatment from a molecular perspective
Combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic drugs (AADs) holds promise in cancer treatment. Whi...
Predicting SARS-CoV-2-specific CD4 and CD8 T-cell responses elicited by inactivated vaccines in healthy adults using machine learning models
Predicting SARS-CoV-2-specific CD4 and CD8 T-cell responses elicited by inactivated vaccines in healthy adults using machine learning models
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlights the importance o...
The AML immune paradox: decoding escape pathways and pioneering checkpoint, vaccine, and combination strategies
The AML immune paradox: decoding escape pathways and pioneering checkpoint, vaccine, and combination strategies
Acute myeloid leukemia (AML) remains a high-mortality cancer due to its aggressive nature and immunosuppressive tumor micr...
The efficacy and safety of venetoclax combined with decitabine in elderly patients with acute myeloid leukemia: a systematic review and meta-analysis
The efficacy and safety of venetoclax combined with decitabine in elderly patients with acute myeloid leukemia: a systematic review and meta-analysis
Acute Myeloid Leukemia (AML) carries a high mortality rate in elderly patients who often face limited treatment options an...
SPOP-dependent destabilization of SYT12 in a GSK-3β-dependent manner in papillary thyroid cancer cells
SPOP-dependent destabilization of SYT12 in a GSK-3β-dependent manner in papillary thyroid cancer cells
Synaptotagmin 12 (SYT12), a protein found to be upregulated in papillary thyroid cancer (PTC), has emerged as a potential ...
Performance of digital breast tomosynthesis with digital mammography for detecting breast cancer in the diagnostic setting: a meta-analysis
Performance of digital breast tomosynthesis with digital mammography for detecting breast cancer in the diagnostic setting: a meta-analysis
To systematically determine the diagnostic accuracy of digital breast tomosynthesis (DBT) in combination with digital mamm...
Ropeginterferon alfa-2b as a promising alternative to conventional interferon in CDA type 1: a case report of two siblings
Ropeginterferon alfa-2b as a promising alternative to conventional interferon in CDA type 1: a case report of two siblings
Congenital dyserythropoietic anemia type I (CDA-I) is a rare hereditary anemia caused by CDAN1 or C15orf41 mutations, with...
Regulation and function of microRNA-152 in various types of cancers: its upstream regulators and downstream targets
Regulation and function of microRNA-152 in various types of cancers: its upstream regulators and downstream targets
MicroRNAs (miRNAs) are key regulators of gene expression that bind to the 3′-untranslated region (3′-UTR) of t...
Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome
Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a rare genetic disease associated with heterogeneous manifest...
Autoantibody profiling using microarray identifies biomarkers associated with chemoimmunotherapy efficacy and immune-related adverse events in lung cancer patients
Autoantibody profiling using microarray identifies biomarkers associated with chemoimmunotherapy efficacy and immune-related adverse events in lung cancer patients
Autoimmune disease associated autoantibodies have been implicated in both immune-related adverse events (irAEs) and chemoi...
Exploring SERTAD4 as a prognostic biomarker and therapeutic target in breast cancer: insights from multidatabase analyses and in vitro studies
Exploring SERTAD4 as a prognostic biomarker and therapeutic target in breast cancer: insights from multidatabase analyses and in vitro studies
Breast cancer (BC) is the most common malignant tumor in women worldwide, and exploring new therapeutic targets is a great...
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Influence of recipient KRAS gene rs712 polymorphisms on the overall survival rate of hepatocellular carcinoma after hepatic transplantation
Hepatocellular carcinoma (HCC) recurrence appears commonly after liver transplantation (LT), and it severely affected the ...
Risk of subsequent primary cancers in bladder cancer survivors
Risk of subsequent primary cancers in bladder cancer survivors
We aimed to investigate the risk of bladder cancer (BCa) survivors developing or dying from 15 specific-subsequent primary...
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
Colorectal cancer (CRC) ranks among the most prevalent malignant tumors worldwide, with a multifactorial etiology encompas...
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Identifying the prognostic significance of mitophagy-associated genes in multiple myeloma: a novel risk model construction
Multiple myeloma (MM) is a highly heterogeneous hematological malignancy that is currently incurable. Individualized thera...
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer
Colorectal cancer is a leading cause of global mortality and presents a significant barrier to improving life expectancy. ...
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Early minimal residual disease eradication in light chain amyloidosis generates deeper and faster cardiac response
Minimal residual disease (MRD) is of growing interest in light chain (AL) amyloidosis and is associated with higher rates ...
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
Development and validation of a model for predicting who can benefit from multiple TACE in HCC patients
This study was to develop and validate a model for predicting who can benefit from multiple transcatheter arterial chemoem...
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4
Understanding the metastatic cascade is critical for the treatment and prevention of cancer-related death. Within a tumor,...
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
Analysis of METTL14 expression in pancreatic cancer and adjacent tissues and its prognostic value for patient outcomes
This study aims to analyze the differential expression of METTL14 in pancreatic cancer (PC) tissues and adjacent normal ti...
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study
Pseudomonas aeruginosa bloodstream infections (PA BSIs) in adults, especially those complicated by sepsis, are associated ...
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
A systematic review and meta-analysis of the endothelial-immune candidate biomarker endoglin in rheumatic diseases
Existing challenges in accurately diagnosing various rheumatic diseases (RDs) have stimulated the search for novel biomark...
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Chronobiological disruptions: unravelling the interplay of shift work, circadian rhythms, and vascular health in the context of stroke risk
Shift work, particularly night shifts, disrupts circadian rhythms and increases stroke risk. This manuscript explores the ...
Current biological implications and clinical relevance of metastatic circulating tumor cells
Current biological implications and clinical relevance of metastatic circulating tumor cells
Metastatic disease and cancer recurrence are the primary causes of cancer-related deaths. Circulating tumor cells (CTCs) a...
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