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Inevitable Progress--Relying on the Immune System, Not Chance
Inevitable Progress--Relying on the Immune System, Not Chance
Locoregional recurrence of head and neck cancer after curative therapy portends a poor prognosis even when resectable. Imm...
Using Circulating Tumor DNA for Colon Cancer Adjuvant Therapy: To Be or Not to Be?
Using Circulating Tumor DNA for Colon Cancer Adjuvant Therapy: To Be or Not to Be?
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FDA Approval Summary: Tivozanib for Relapsed or Refractory Renal Cell Carcinoma
FDA Approval Summary: Tivozanib for Relapsed or Refractory Renal Cell Carcinoma
FDA Approval Summary: Tivozanib for Relapsed or Refractory Renal Cell Carcinoma Elaine Chang, Ch...
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
AbstractPurpose: Selinexor is an oral selective inhibitor of exportin-1 (XPO1) with efficacy in various solid and hematolo...
Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors
Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors
AbstractPurpose: The aim of the study was to determine safety, antitumor activity, and pharmacodynamic profile of mogamuli...
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck
AbstractPurpose: Surgery often represents the best chance for disease control in locoregionally recurrent squamous cell ca...
A PD-1/PD-L1 Proximity Assay as a Theranostic Marker for PD-1 Blockade in Patients with Metastatic Melanoma
A PD-1/PD-L1 Proximity Assay as a Theranostic Marker for PD-1 Blockade in Patients with Metastatic Melanoma
A PD-1/PD-L1 Proximity Assay as a Theranostic Marker for PD-1 Blockade in Patients with Metastatic Mela...
Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer
Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer
Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Canc...
Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity ...
Neoadjuvant Chemotherapy and Immunotherapy in Luminal B-like Breast Cancer: Results of the Phase II GIADA Trial
Neoadjuvant Chemotherapy and Immunotherapy in Luminal B-like Breast Cancer: Results of the Phase II GIADA Trial
AbstractPurpose: The role of immunotherapy in hormone receptor (HR)-positive, HER2-negative breast cancer is underexplored...
T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Translational RelevanceOligodendrogliomas are intrinsic brain tumors that are incurable. In a screen for potential immunog...
Relevance of pRB Loss in Human Malignancies
Relevance of pRB Loss in Human Malignancies
AbstractThe retinoblastoma tumor suppressor protein (pRB) is a known regulator of cell-cycle control; however, recent stud...
Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology
Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology
Every profession has an essential, behind-the-scenes component without which it cannot function. Medicine is no exception....
A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma
A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma
AbstractPurpose: Ceritinib is an orally bioavailable, small-molecule inhibitor of anaplastic lympoma kinase (ALK), insulin...
Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome
Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome
Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome ...