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MAVS signaling shapes microglia responses to neurotropic virus infection
MAVS signaling shapes microglia responses to neurotropic virus infection
Viral encephalitis is characterized by a series of immunological reactions that can control virus infection in the brain, ...
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury
Patients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TB...
Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer’s disease
Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer’s disease
It is now realized that peripheral inflammation and abnormal immune responses, especially T cells, contribute to the devel...
Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia
Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia
The blood-brain barrier (BBB) is a critical interface that maintains the central nervous system homeostasis by controlling...
MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis
MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS) with the immune system attacki...
Delayed plasma kallikrein inhibition fosters post-stroke recovery by reducing thrombo-inflammation
Delayed plasma kallikrein inhibition fosters post-stroke recovery by reducing thrombo-inflammation
Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic strok...
Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period
Neonatal Chlamydia muridarum respiratory infection causes neuroinflammation within the brainstem during the early postnatal period
Respiratory infections are one of the most common causes of illness and morbidity in neonates worldwide. In the acute phas...
Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
Cystatin F attenuates neuroinflammation and demyelination following murine coronavirus infection of the central nervous system
Cystatin F is a secreted lysosomal cysteine protease inhibitor that has been implicated in affecting the severity of demye...
Estrogen-immuno-neuromodulation disorders in menopausal depression
Estrogen-immuno-neuromodulation disorders in menopausal depression
A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult...
Correction: Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
Correction: Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease
Neuroinflammation substantially contributes to the pathology of Alzheimer’s disease (AD), the most common form of de...
Parkinson’s disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Parkinson’s disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder characterized by the aggregation of ^...
SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
Neuropathic pain (NP) is a kind of intractable pain. The pathogenesis of NP remains a complicated issue for pain managemen...
Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury
Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury
Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the compl...
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia
Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequ...
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studi...
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice
Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicat...
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity
Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via t...
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B ...
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice
Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer&...
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concent...
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Correction: miR155, TREM2, INPP5D: Disease stage and cell-type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including fron...
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Correction : IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells
Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-re...
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). I...
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of pr...
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
Inflammatory response triggered by innate immunity plays a pivotal element in the progress of ischemic stroke. Receptor-in...
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury
Neonatal encephalopathy following hypoxia–ischemia (HI) is a leading cause of childhood death and morbidity. Hypothe...
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1
Chronic activation and dysfunction of microglia have been implicated in the pathogenesis and progression of many neurodege...
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