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Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Personalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a majo...
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tiss...
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Cite this articleKhiali, S., Taban-Sadeghi, M., Sarbakhsh, P. et al. Correction to: Empagliflozin and colchicine in patien...
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Spironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone...
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome is a rare and potentially fatal adverse drug reaction caused by serotonergic drugs and is due to an inc...
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
To investigate the effect of azilsartan on myocardial remodeling after acute myocardial infarction (AMI). A total of 200 A...
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
The association between antidepressant use and the risk of seizures remains controversial. Therefore, this meta-analysis e...
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Through predictable pharmacokinetics—including a convenient fixed-dose regimen, direct oral anticoagulants (DOACs) a...
Untapped options to reduce waste from blister packaging for tablets and capsules
Untapped options to reduce waste from blister packaging for tablets and capsules
In Europe, most medicines are taken orally and primarily packaged as single solid oral dosage forms (SODF) in blister cham...
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
This study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy. PubMed, Ovi...
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Therapeutic drug monitoring of tacrolimus using trough concentration (Cmin) is mandatory to ensure drug efficacy and safet...
Association of clozapine and norclozapine levels with patient and therapy characteristics—focus on interaction with valproic acid
Association of clozapine and norclozapine levels with patient and therapy characteristics—focus on interaction with valproic acid
The goal of the study was to examine clozapine (CLZ) and norclozapine (NCLZ) therapeutic drug monitoring (TDM) data and as...
Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
This study aimed to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of ivosidenib in Chinese patients with rela...
The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
To investigate the association between proton pump inhibitors (PPIs) administration during hospitalization and mortality a...
Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
To develop a population pharmacokinetic (PPK) model for methotrexate (MTX) dosage for all ages, assess the association bet...
The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of liver disease, affecting 30% of the global populat...
Effect of intravenous lidocaine on outcomes in patients receiving propofol for gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis
Effect of intravenous lidocaine on outcomes in patients receiving propofol for gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis
Gastrointestinal endoscopic procedures (GEPs) are frequently employed for the diagnosis and treatment of various gastroint...
Risk factors for acute kidney injury associated with intravenous vancomycin in neurosurgical inpatients: a retrospective study
Risk factors for acute kidney injury associated with intravenous vancomycin in neurosurgical inpatients: a retrospective study
Vancomycin (VAN) is widely used in neurosurgical patients for intracranial infections. We aimed to assess the incidence an...
Socioeconomic factors associated with poor medication adherence in patients with type 2 diabetes
Socioeconomic factors associated with poor medication adherence in patients with type 2 diabetes
This study aims to determine initiation and persistence for patients with type 2 diabetes receiving their first prescripti...
Risk of gastric cancer among long-term proton pump inhibitor users: a population-based cohort study
Risk of gastric cancer among long-term proton pump inhibitor users: a population-based cohort study
To elucidate whether long-term proton pump inhibitor (PPI) users have an increased gastric cancer (GC) risk. We searched t...
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Fifty-six (56) patients scheduled for arthroplasty, received 7-day extended-release buprenorphine transdermal patches (5&a...
Mechanisms of landiolol-mediated positive inotropy in critical care settings
Mechanisms of landiolol-mediated positive inotropy in critical care settings
To present the potential mechanisms by which landiolol enhances a positive inotropic response in critically ill patients. ...
Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy
Cytochrome P450 activity in rheumatoid arthritis patients during continuous IL-6 receptor antagonist therapy
Inflammation suppresses cytochrome P450 (CYP) enzyme activity, and single-dose interleukin 6 receptor antagonists (anti-IL...
Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data
Trends in prescribing and outcomes in obese versus non-obese patients receiving rivaroxaban therapy: an observational study using real-world data
To investigate real-world prescribing trends and clinical outcomes based on body mass index (BMI) categorization in patien...
Variation of tafamidis plasma levels during the treatment of TTR amyloidosis patients with Glu89Gln mutation
Variation of tafamidis plasma levels during the treatment of TTR amyloidosis patients with Glu89Gln mutation
The transthyretin kinetic stabilizer tafamidis, used as a first-line therapy of amyloidosis patients, binds selectively to...
The sound and surprise: overlapping meta-analyses on the topic of safety and efficacy of PD-1 and PD-L1 inhibitors in the treatment of non-small cell lung cancer
The sound and surprise: overlapping meta-analyses on the topic of safety and efficacy of PD-1 and PD-L1 inhibitors in the treatment of non-small cell lung cancer
To analyze the characteristics of overlapping meta-analyses based on randomized controlled trials (RCTs) which reported PD...
Effect of timing of administration on lipid-lowering efficacy of statins-meta-analysis
Effect of timing of administration on lipid-lowering efficacy of statins-meta-analysis
To investigate the effect of timing of statin administration on lipid-lowering efficacy. Computer searches of Pubmed, Emba...
Incidence and risk factors of drug-induced kidney injury in children: a systematic review and meta-analysis
Incidence and risk factors of drug-induced kidney injury in children: a systematic review and meta-analysis
To comprehensively summarize the incidence and risk factors of drug-induced kidney injury (DIKI) in children. We systemati...
The impact of a summative national prescribing assessment and curriculum type on the development of the prescribing competence of junior doctors
The impact of a summative national prescribing assessment and curriculum type on the development of the prescribing competence of junior doctors
The primary aim of this study was to investigate the effect of including the Dutch National Pharmacotherapy Assessment (DN...
Differential inhibition of platelet function by cilostazol in combination with clopidogrel
Differential inhibition of platelet function by cilostazol in combination with clopidogrel
To assess the antiplatelet effect of cilostazol clinically, we compared the effects of cilostazol in combination with clop...
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