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LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
LPA released from dying cancer cells after chemotherapy inactivates Hippo signaling and promotes pancreatic cancer cell repopulation
The Hippo pathway in the tumorigenesis and progression of PDAC, with lysophosphatidic acid (LPA) regulating the Hippo path...
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Meningeal leukaemic aggregates as foci of cell expansion and chemoresistance in acute lymphoblastic leukaemia metastasis
Central nervous system (CNS) involvement and/or relapse remains one of the most important causes of morbidity/mortality in...
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
Evaluating the prognostic significance of tumor deposits in gastric cancer and strategies for their integration into the TNM staging system: a single-center retrospective study
To propose a new optimal strategy for incorporating tumor deposit (TD) into TNM staging. Totally, 2730 consecutive gastric...
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
Malignant melanoma is the deadliest skin cancer, with a poor prognosis in advanced stages. We reported that both Hedgehog-...
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy
Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), tumor-associated neutrophils...
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Thymidine kinase 1 indicates resistance to immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma
Immune checkpoint plus tyrosine kinase inhibition (IO + TKI) has emerged as the first-line therapy in metastat...
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer
Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cance...
Allelic expression imbalance of variants in childhood acute lymphoblastic leukemia
Allelic expression imbalance of variants in childhood acute lymphoblastic leukemia
Germline CDKN2A variant predisposes to childhood acute lymphoblastic leukemia (ALL) through allelic expression imbalance (...
From benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST): a gaming among multiple factors
From benign neurofibromas to malignant peripheral nerve sheath tumors (MPNST): a gaming among multiple factors
Almost all patients of Neurofibromatosis Type I (NF1) develop benign peripheral nerve tumors called neurofibromas, which a...
Tumor-specific CXCR6 positive precursor CD8 T cells mediate tumor control in metastatic melanoma
Tumor-specific CXCR6 positive precursor CD8 T cells mediate tumor control in metastatic melanoma
Adoptive cell therapy (ACT) mediates durable and complete regression of various cancers. However, its efficacy is limited ...
Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance
Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance
Osterix, encoded by SP7, is a transcription factor crucial in osteoblast differentiation and bone formation. While initial...
Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth
Sirtuin 3-mediated delactylation of malic enzyme 2 disrupts redox balance and inhibits colorectal cancer growth
Post-translational modifications, such as lactylation, are emerging as critical regulators of metabolic enzymes in cancer ...
Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis
Trained immunity alleviates the progression of melanoma during sepsis-associated immunoparalysis
Patients who survive the excessive inflammatory phase of sepsis experience prolonged immunoparalysis/immunosuppression. Du...
Exosomes delivering miR-129-5p combined with sorafenib ameliorate hepatocellular carcinoma progression via the KCTD1/HIF-1α/VEGF pathway
Exosomes delivering miR-129-5p combined with sorafenib ameliorate hepatocellular carcinoma progression via the KCTD1/HIF-1α/VEGF pathway
Potassium channel tetramerization domain-containing 1 (KCTD1) plays a critical role in transcriptional regulation and adip...
HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
Epithelial-mesenchymal transition (EMT) plays critical roles in tumor progress and treatment resistance of ovarian cancer ...
THEMIS2 contributes to ovarian cancer metastasis via DOCK4-mediated activation of Rap1 signaling
THEMIS2 contributes to ovarian cancer metastasis via DOCK4-mediated activation of Rap1 signaling
Ovarian cancer (OC) is the most lethal gynecological malignancy, with widespread metastasis and ascites being the leading ...
State of the art in CAR-based therapy: In vivo CAR production as a revolution in cell-based cancer treatment
State of the art in CAR-based therapy: In vivo CAR production as a revolution in cell-based cancer treatment
Chimeric antigen receptor (CAR) therapy has successfully treated relapsed/refractory hematological cancers. This strategy ...
Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Department of Medical Research, Chi-Mei Medical Center, Tainan, TaiwanChien-Feng Li & Ti-Chun ChanNational Cancer Rese...
Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells ...
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
A.V.R. Kornepati, R.K. Vadlamudi, T.J. Curiel, Programmed death ligand 1 signals in cancer cells. Nat. Rev. Cancer. 22, 17...
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heter...
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies....
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been ident...
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Establishing an immunosuppressive premetastatic niche (PMN) in distant organs is crucial for breast cancer metastasis. Vas...
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
The human AlkB homolog (ALKBH) dioxygenase superfamily plays a crucial role in gene regulation and is implicated in cancer...
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase...
BCAT1 contributes to the development of TKI-resistant CML
BCAT1 contributes to the development of TKI-resistant CML
Although most of chronic myeloid leukemia (CML) patients can be effectively treated by the tyrosine kinase inhibitors (TKI...
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has c...
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Autophagy is frequently observed in tissues during the aging process, yet the tissues most strongly correlated with autoph...
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
Ubiquitination is one of the important modification of proteins which can be reversed by deubiquitinating enzymes (DUBs). ...
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