SCI时时刷

search
+
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
PIK3CA mutation or overexpression is associated with immunotherapy resistance in multiple cancer types, but is also parado...
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
Cancer immunotherapy provides durable response and improves survival in a subset of head and neck squamous cell carcinoma ...
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial dysbiosis is considered as a hallmark of colorectal cancer (CRC). Trimethylamine-N-oxide (TMAO) as a gut microbi...
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
Glucose not only provides energy for tumor cells, but also provides various biomolecules that are essential for their surv...
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
Growth differentiating Factor 15 (GDF15) is linked to several cancers, but its effect on chemoresistance in colorectal can...
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Sunitinib is a recommended drug for metastatic renal cell carcinoma (RCC). However, the therapeutic potential of sunitinib...
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Tumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs ...
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of cr...
The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
Vulvar squamous cell carcinoma (VSCC) is a rare disease with a poor prognosis. To date, there’s no proper in vitro m...
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β is related to the function of T cells in the tumor microenvironment. However, the characteristics of TGF-β...
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
In recent years, there have been great improvements in the therapy of renal cell carcinoma. Nevertheless, the therapeutic ...
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in...
miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
“Driver gene-negative” non-small cell lung cancer (NSCLC) currently has no approved targeted drug, due to the ...
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
High levels of heterogeneity and immunosuppression characterize the HCC immune microenvironment (TME). Unfortunately, the ...
Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN
Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN
Department of Neurosurgery, Henan Province People’s Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, ...
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
PiwiL1 has been reported to be over-expressed in many cancers. However, the molecular mechanism by which these proteins co...
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatase...
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
Accumulating studies have shown that tumors are regulated by nerves, and there is abundant nerve infiltration in the tumor...
CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
Cancer cells are characterized as the uncontrolled proliferation, which demands high levels of nucleotides that are buildi...
Retraction Note: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
Retraction Note: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
TRPV1 inhibition suppresses non-small cell lung cancer progression by inhibiting tumour growth and enhancing the immune response
TRPV1 inhibition suppresses non-small cell lung cancer progression by inhibiting tumour growth and enhancing the immune response
TRPV1 is a nonselective Ca2+ channel protein that is widely expressed and plays an important role during the occurrence an...
E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression
E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression
Despite lung cancer is one of the leading causes of cancer-related deaths, it remains hard to discover effective diagnosti...
Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways
Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways
Cancer/testis antigen-45A1 (CT45A1) is overexpressed in various types of cancer but is not expressed in healthy women. The...
Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer
Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer
The histone deacetylase inhibitor (HDACi), belinostat, has had limited therapeutic impact in solid tumors, such as colon c...
Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach
Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach
Preoperative neoadjuvant chemotherapy may not improve the prognosis of patients with hepatoid adenocarcinoma of the stomac...
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
The gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeuti...
Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein
Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck disease with a high incidence of distant metastases. Enlarge...
The microbiota and renal cell carcinoma
The microbiota and renal cell carcinoma
Renal cell carcinoma (RCC) accounts for about 2% of cancer diagnoses and deaths worldwide. Recent studies emphasized the c...
Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells
Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells
Targeting glycolysis in cancer is an attractive approach for therapeutic intervention. 2-Deoxyglucose (2DG) is a synthetic...
Correction: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity
Correction: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity
Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children?s Medical Center, S...
阅读更多
format_indent_increase