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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma
Neuroblastoma (NB) is a predominantly pediatric cancer with greater than 90% of cases arising in children under the age of...
Advancing glioblastoma treatment by targeting metabolism
Advancing glioblastoma treatment by targeting metabolism
Volume 51, May 2024, 100985Author links open overlay panel, , , , , , AbstractAlterations in cellular metabolism are impor...
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
ST6GAL1 is associated with poor response to chemoradiation in rectal cancer
Volume 51, May 2024, 100984Author links open overlay panel, , , , , , , AbstractIntroductionColorectal cancer is the third...
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but th...
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Volume 51, May 2024, 100989Author links open overlay panel, , , , , , AbstractGene mutations are a source of genetic insta...
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
BackgroundEarly-onset colorectal cancer (EO-CRC) incidence and prevalence trends in the rise in high income countries, suc...
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
KeywordsDihydroartemisinin (DHA)CisplatinEndoplasmic reticulum (ER) stressReactive oxygen species (ROS)Prostaglandin G/H s...
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
KeywordsMechanotherapeuticsSonopermeationNanomedicineImmune checkpoint inhibitionUltrasoundAbbreviationsTMEtumor microenvi...
Corrigendum to “Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment” [Neoplasia, Volume 22, Issue 2 (2020) 111–119]
Corrigendum to “Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment” [Neoplasia, Volume 22, Issue 2 (2020) 111–119]
Volume 51, May 2024, 100986Author links open overlay panelSteven Kregel a b c, Chao Wang d, Xin Han d, Lanbo Xiao a b c, E...
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]
Volume 51, May 2024, 100995Author links open overlay panelJae Eun Choi a b c, Monique E. Verhaegen d, Sahr Yazdani a c, Ro...
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms
Volume 52, June 2024, 100996Author links open overlay panel, , , , , , AbstractPapillary thyroid carcinoma (PTC) is the mo...
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
KeywordsPancreatic ductal adenocarcinomaTRIP13Tumor progressionMetastasisImmune responseAbbreviationsEMTepithelial-mesench...
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
ObjectiveThis study aimed to investigate the causal relationship between mitochondrial biological function and lung cancer...
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of he...
Acral melanoma: new insights into the immune and genomic landscape
Acral melanoma: new insights into the immune and genomic landscape
Volume 46, December 2023, 100947Author links open overlay panel, , , AbstractAcral melanoma is a rare subtype of melanoma ...
A sensitive and robust plasma-based DNA methylation panel for early detection of target gastrointestinal cancers
A sensitive and robust plasma-based DNA methylation panel for early detection of target gastrointestinal cancers
Volume 46, December 2023, 100941Author links open overlay panel, , , , , , , , , , , , , , , Highlights•A novel, cost-effe...
Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center
Patient recruitment into clinical studies of solid malignancies during the COVID-19 pandemic in a tertiary cancer center
Volume 46, December 2023, 100946Author links open overlay panel, , , , , , , , , , , , , , , , Highlights•Assessment of cl...
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system
Metastatic renal cell carcinoma (RCC) remains an incurable disease for most patients highlighting an urgent need for new t...
Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy
Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy
Volume 46, December 2023, 100949Author links open overlay panel, , , , , , , , , , AbstractTriple negative breast cancer (...
Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations
Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations
Volume 46, December 2023, 100940Author links open overlay panel, , , AbstractRadiation therapy is an established and effec...
Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice
Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice
Original raw data in this manuscript were deposited to Sequence Read Archive (SRA) database of NCBI (Accession number: SRP...
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells
Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells
PurposeHuman papilloma virus (HPV) positive head and neck squamous cell carcinoma (HNSCC) tumors respond significantly bet...
Integration of bioinformatics and machine learning strategies identifies APM-related gene signatures to predict clinical outcomes and therapeutic responses for breast cancer patients
Integration of bioinformatics and machine learning strategies identifies APM-related gene signatures to predict clinical outcomes and therapeutic responses for breast cancer patients
KeywordsAntigen processing and presentation machineryGene signaturesBreast cancerRisk assessmentGene mutationImmunotherapy...
Targeting IL-23 for the interception of obesity-associated colorectal cancer
Targeting IL-23 for the interception of obesity-associated colorectal cancer
Volume 45, November 2023, 100939Author links open overlay panel, , , , , , , , AbstractInflammation and obesity are two ma...
Common and distinct patterns of acquired uniparental disomy and homozygous deletions between lung squamous cell carcinomas and lung adenocarcinoma
Common and distinct patterns of acquired uniparental disomy and homozygous deletions between lung squamous cell carcinomas and lung adenocarcinoma
Acquired uniparental disomy (aUPD) is a chromosomal alteration that can lead to homozygosity of existing aberrations. We u...
ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma
ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma
TP63 (p63) is strongly expressed in lower-grade carcinomas of the head and neck, skin, breast, and urothelium to maintain ...
ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways
ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways
Volume 45, November 2023, 100936Author links open overlay panel, , , , , , , , , AbstractThe mortality rates of gastric ca...
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study
The therapeutic scenario of Human Epidermal Growth Factor Receptor 2 positive advanced breast cancer (ABC) has been recent...
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membra...
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
Volume 44, October 2023, 100934Author links open overlay panel, , , , , , , , , , , , , , , , , , AbstractBackgroundThe en...
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