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Gene of the month: DDIT3
Gene of the month: DDIT3
DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to ...
Gender distribution in pathology journal editorial boards: a call to action
Gender distribution in pathology journal editorial boards: a call to action
The article by Nguyen et al reveals that Pathology, like other medical specialties, has an underrepresentation of women au...
Gender distribution in surgical pathology journal publications and editorial boards
Gender distribution in surgical pathology journal publications and editorial boards
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Risk assessment in pT1 colorectal cancer
Risk assessment in pT1 colorectal cancer
IntroductionColorectal cancer (CRC) is one of the most common malignancies, resulting in 16 800 deaths in the UK annually....
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
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Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
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Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionTriple-negative bre...
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
A woman in her late 70s was referred to urology clinic to consider intervention for a biopsy-proven 24 mm WHO/Internationa...
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue tumour of intermediate (rarely metastasising) malignant potential,...
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
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Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Haemoglobin H (Hb H) disease is a form of alpha (α)-thalassaemia where three of the four α-globin gene alleles are deleted...
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
WHAT IS ALREADY KNOWN ON THIS TOPICThis is a new concept, the implementation of an ISO15189 accredited next-generation seq...
Successful demand management in diagnostic immunology testing
Successful demand management in diagnostic immunology testing
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Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
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Unravelling the USP6 gene: an update
Unravelling the USP6 gene: an update
Ubiquitin-specific protease 6 (USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myos...
Failure to thrive in a man in his late forties
Failure to thrive in a man in his late forties
Clinical presentationA man in his late 40s with a 30 pack-year cigarette smoking history and no other comorbidities presen...
Ketamine: friend or foe?
Ketamine: friend or foe?
Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-...
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
IntroductionOesophageal adenocarcinoma (EAC) is an aggressive disease with a mean 5-year survival rate of only 15%.1 Most ...
Development of a LAG-3 immunohistochemistry assay for melanoma
Development of a LAG-3 immunohistochemistry assay for melanoma
IntroductionImmune checkpoint inhibitor–based therapies have greatly improved clinical outcomes across multiple disease se...
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
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MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
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Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
IntroductionThe National Institute for Health and Care Excellence (NICE) produces evidence-based guidance, based on clinic...
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
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One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
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Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
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Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
IntroductionRapid laboratory diagnosis of SARS-CoV-2 is essential for hospital management of COVID-19. In addition to aidi...
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Biotin interference in immunoassays using biotin-streptavidin binding technology is well recognised by clinical laboratori...
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
We read with interest a recent study analysing industry payments to pathologists in the USA.1 In this study, Murayama and ...
Drug-induced hyperammonaemia
Drug-induced hyperammonaemia
IntroductionHyperammonaemia (HA) (>40 µmol/L, 68 μg/L in adults, although method dependent) arises due to a number of c...
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
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