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My approach to assessing for colorectal polyp cancer
My approach to assessing for colorectal polyp cancer
Assessing a locally excised colorectal adenoma for malignancy is a common but often challenging scenario. This article out...
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
Systematic literature review of published cases of reactive plasmacytosis in peripheral blood and bone marrow
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Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate: conflicting recommendations confuse clinicians
Intraductal carcinoma of the prostate (IDCP) generally represents a growth pattern of invasive aggressive acinar prostate ...
The highs and lows of grading intraductal carcinoma of the prostate
The highs and lows of grading intraductal carcinoma of the prostate
Accurate histological diagnosis and grading are essential for appropriate management of prostate cancer (PCa), yet there r...
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
IntroductionInvasive breast carcinomas with amplification of human epidermal growth factor receptor 2 (ERBB2) gene or over...
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICRecent studies have highlighted the effectiveness of epidermal growth factor receptor (...
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
Tumour-infiltrating lymphocyte subsets and their individual prognostic impact in oral squamous cell carcinoma
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Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
Unravelling interobserver variability in gastrointestinal glandular neoplasia: a contemporary study of US and Korean pathologists
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Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
Idiopathic granulomatous mastitis: a 5-year retrospective review of cases in a tertiary centre in Dublin, Ireland
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Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
Performance evaluation of a CRISPR Cas9-based selective exponential amplification assay for the detection of KRAS mutations in plasma of patients with advanced pancreatic cancer
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Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
Optimal carcinoembryonic antigen (CEA) cutoff values in the diagnosis of neoplastic mucinous pancreatic cysts differ among assays
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Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman Disease of pancreas: rare aetiology mimicking malignancy
Rosai-Dorfman disease (RDD) is a non-Langerhans cell histiocytosis which usually presents as painless lymphadenopathy. Ext...
Gene of the month: DDIT3
Gene of the month: DDIT3
DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to ...
Gender distribution in pathology journal editorial boards: a call to action
Gender distribution in pathology journal editorial boards: a call to action
The article by Nguyen et al reveals that Pathology, like other medical specialties, has an underrepresentation of women au...
Gender distribution in surgical pathology journal publications and editorial boards
Gender distribution in surgical pathology journal publications and editorial boards
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Risk assessment in pT1 colorectal cancer
Risk assessment in pT1 colorectal cancer
IntroductionColorectal cancer (CRC) is one of the most common malignancies, resulting in 16 800 deaths in the UK annually....
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
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Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
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Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
Comparison of assessment of programmed death-ligand 1 (PD-L1) status in triple-negative breast cancer biopsies and surgical specimens
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionTriple-negative bre...
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
Tumour-to-tumour metastasis of breast cancer (donor) and clear cell renal cell carcinoma (recipient): a case report
A woman in her late 70s was referred to urology clinic to consider intervention for a biopsy-proven 24 mm WHO/Internationa...
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Kinase expression in angiomatoid fibrous histiocytoma: panTRK is commonly expressed in the absence of NTRK rearrangement
Angiomatoid fibrous histiocytoma (AFH) is a soft tissue tumour of intermediate (rarely metastasising) malignant potential,...
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
Efficacy of postmortem CT and tissue sampling in establishing the cause of death in clinical practice: a prospective observational study
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Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Non-deletional haemoglobin H (Hb H) disease morphologically masquerading as congenital dyserythropoietic anaemia type II: a diagnostic pitfall
Haemoglobin H (Hb H) disease is a form of alpha (α)-thalassaemia where three of the four α-globin gene alleles are deleted...
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
Implementation of an ISO15189 accredited next-generation sequencing service with the fully automated Ion Torrent Genexus: the experience of a clinical diagnostic laboratory
WHAT IS ALREADY KNOWN ON THIS TOPICThis is a new concept, the implementation of an ISO15189 accredited next-generation seq...
Successful demand management in diagnostic immunology testing
Successful demand management in diagnostic immunology testing
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Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
Modes of assay interference and the effectiveness of serum pretreatment approaches in detection of anti-HLA antibodies
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Unravelling the USP6 gene: an update
Unravelling the USP6 gene: an update
Ubiquitin-specific protease 6 (USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myos...
Failure to thrive in a man in his late forties
Failure to thrive in a man in his late forties
Clinical presentationA man in his late 40s with a 30 pack-year cigarette smoking history and no other comorbidities presen...
Ketamine: friend or foe?
Ketamine: friend or foe?
Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-...
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
IntroductionOesophageal adenocarcinoma (EAC) is an aggressive disease with a mean 5-year survival rate of only 15%.1 Most ...
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