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A computational approach to analyzing the functional and structural impacts of Tripeptidyl-Peptidase 1 missense mutations in neuronal ceroid lipofuscinosis
A computational approach to analyzing the functional and structural impacts of Tripeptidyl-Peptidase 1 missense mutations in neuronal ceroid lipofuscinosis
Neuronal ceroid-lipofuscinosis (NCLs) are a group of severe neurodegenerative conditions, most likely present in infantile...
Nuclear translocation of STAT5 initiates iron overload in huntington’s disease by up-regulating IRP1 expression
Nuclear translocation of STAT5 initiates iron overload in huntington’s disease by up-regulating IRP1 expression
Mutant huntingtin (mHtt) proteins interact to form aggregates, disrupting cellular functions including transcriptional dys...
Alterations of the glutamatergic system in diabetes mellitus
Alterations of the glutamatergic system in diabetes mellitus
Diabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels caused by a lack of insulin pro...
Correction to: Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis
Correction to: Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis
Cite this articleMojaverrostami, S., Pasbakhsh, P., Madadi, S. et al. Correction to: Calorie restriction promotes remyelin...
Proteomics revealed an association between ribosome-associated proteins and amyloid beta deposition in Alzheimer's disease
Proteomics revealed an association between ribosome-associated proteins and amyloid beta deposition in Alzheimer's disease
Most scholars believe that amyloid-beta (Aβ) has the potential to induce apoptosis, stimulate an inflammatory cascade...
Etomidate inhibits tumor growth of glioblastoma by regulating M1 macrophage polarization
Etomidate inhibits tumor growth of glioblastoma by regulating M1 macrophage polarization
Glioblastoma (GBM) is a common primary central nervous system tumor. Although the multimodal integrated treatment for GBM ...
NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke
NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke
Brain stroke (BS, also known as a cerebrovascular accident), represents a serious global health crisis. ...
Therapeutic potentialities of green tea (Camellia sinensis) in ischemic stroke: biochemical and molecular evidence
Therapeutic potentialities of green tea (Camellia sinensis) in ischemic stroke: biochemical and molecular evidence
Ischemic stroke is a leading cause of disability and death in patients. Despite considerable recent advances in the treatm...
Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach
Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach
Atypical parkinsonism (AP) is a group of complex neurodegenerative disorders with marked clinical and pathophysiological h...
New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model
New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model
This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudra...
Molecular and in silico investigation of a novel ECHS1 gene mutation in a consanguine family with short-chain enoyl-CoA hydratase deficiency and Mt-DNA depletion: effect on trimer assembly and catalytic activity
Molecular and in silico investigation of a novel ECHS1 gene mutation in a consanguine family with short-chain enoyl-CoA hydratase deficiency and Mt-DNA depletion: effect on trimer assembly and catalytic activity
Short-chain enoyl-CoA hydratase deficiency (ECHS1D) is a rare congenital metabolic disorder that follows an autosomal rece...
Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis
Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis
Selenium-containing agents showed novel anticancer activity by triggering pro-oxidative mechanism. Studies confirmed that ...
Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation
Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is ...
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Traumatic brain injury (TBI), as a serious central nervous system disease, can result in severe neurological dysfunction o...
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruit...
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Stroke is a leading cause of disability and death worldwide. Ivermectin is a broad-spectrum anti-parasitic agent with pote...
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series
Metabolic dysfunction is an important factor in the pathogenesis of motor neuron disease, but its prevalence and associati...
Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
Neuroinflammation is identified as significant inflammatory reactions occurring in the central nervous system. Lipopolysac...
G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats
G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats
Stroke remains the leading cause of death and disability in the world. A new potential treatment for stroke is the granulo...
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
End-stage kidney disease and mild cognitive impairment (ESKD-MCI) affect the quality of life and long-term treatment outco...
Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
Chaigui granules are a novel manufactured traditional Chinese antidepressant medicine, which is originated from the ancien...
Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach
Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Approximately, around 2% to 3% percent of the general ...
Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Long non-coding RNAs (lncRNAs) have been recently considered as one of the regulatory mechanisms of the nervous system. He...
Systematic review and meta-analysis of the effects of exercise on cognitive impairment and neuroprotective mechanisms in diabetes mellitus animal models
Systematic review and meta-analysis of the effects of exercise on cognitive impairment and neuroprotective mechanisms in diabetes mellitus animal models
This study aims to assess the effects of exercise on cognitive impairment behavioral performance and neuroprotective mecha...
Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia
Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia
Andrographolide (Andro), a labdane diterpene, possesses anti-inflammatory properties and has been used to treat numerous i...
Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP
Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic e...
Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus
Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus
Brain damage caused by ethanol abuse may lead to permanent damage, including severe dementia. The aim of this study was to...
Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase
Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase
Hypothyroidism causes learning and memory impairment. Considering the neuroprotective properties of thiamine (Vitamin B1),...
Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy
Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy
Obesity is a worldwide problem in which genetic factors have a prominent role. We have selected two single nucleotide poly...
Unlocking therapeutic potential of trigonelline through molecular docking as a promising approach for treating diverse neurological disorders
Unlocking therapeutic potential of trigonelline through molecular docking as a promising approach for treating diverse neurological disorders
Neurological disorders pose significant challenges in terms of treatment options, necessitating the exploration of novel t...
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