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Exercise-produced irisin effects on brain-related pathological conditions
Exercise-produced irisin effects on brain-related pathological conditions
Exercise increases peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) expression, which in...
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disorder with early autophagy deficits. Our study probed the role of l...
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Antidepressants remain the first-line treatment for depression. However, the factors influencing medication response are s...
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Depression is a mental disorder characterised by persistent low mood, anhedonia and cognitive impairment that affects an e...
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute liver failure or chronic liver injury. Liver dysfu...
Role of peripheral inflammation in minimal hepatic encephalopathy
Role of peripheral inflammation in minimal hepatic encephalopathy
Many patients with liver cirrhosis show minimal hepatic encephalopathy (MHE) with mild cognitive impairment (MCI) and moto...
Genomic, epigenomic and transcriptomic landscape of glioblastoma
Genomic, epigenomic and transcriptomic landscape of glioblastoma
The mostly aggressive and extremely malignant type of central nervous system is Glioblastoma (GBM), which is characterized...
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Neurological disorders are the primary cause of human disability and mortality globally, however, current medications slig...
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. The cleavage factor Im 25 (CFIm25)...
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Hepatic encephalopathy (HE) is a syndrome that is associated with both acute and chronic liver injury. It manifests as a w...
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Several recent studies have attempted to understand how fasting has benefits for body health, especially the nervous syste...
ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats
ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats
Changpu Yujin Tang(CPYJT), a Chinese herbal compound, is an effective therapeutic strategy for pediatric patients with Tou...
Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study
Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study
Diabetic cognitive impairment is a common complication in type 2 diabetes. Berberine (BBR) is an isoquinoline alkaloid tha...
SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization
SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization
Sevoflurane exposure can result in neurotoxicity especially among children, which remains an important complication after ...
Integrated network pharmacology analysis and experimental validation to investigate the mechanism of Flavan-3-ols and aromatic resins in depression
Integrated network pharmacology analysis and experimental validation to investigate the mechanism of Flavan-3-ols and aromatic resins in depression
The present investigation delved into the pharmacological mechanisms underlying the management of depression through Flava...
Hyperornithinemia-hyperammonemia-homocitrullinuria: a rare neurometabolic disorder in two siblings
Hyperornithinemia-hyperammonemia-homocitrullinuria: a rare neurometabolic disorder in two siblings
Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome is an extremely rare disorder of urea cycle, with few patients...
The alpha2-adrenergic receptor agonist clonidine protects against cerebral ischemia/reperfusion induced neuronal apoptosis in rats
The alpha2-adrenergic receptor agonist clonidine protects against cerebral ischemia/reperfusion induced neuronal apoptosis in rats
Apoptosis is the crucial pathological mechanism following cerebral ischemic injury. Our previous studies demonstrated that...
Co-occurrence of PRKN and SYNJ1 variants in Early-Onset Parkinson's disease
Co-occurrence of PRKN and SYNJ1 variants in Early-Onset Parkinson's disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease globally, with a fast-growing preval...
Inhibitor of apoptosis stimulating protein of p53 protects against MPP+-induced neurotoxicity of dopaminergic neurons
Inhibitor of apoptosis stimulating protein of p53 protects against MPP+-induced neurotoxicity of dopaminergic neurons
Inhibitor of apoptosis stimulating protein of p53 (iASPP) is related to the pathogenesis of several neurological disorders...
Blood-based therapies to combat neurodegenerative diseases
Blood-based therapies to combat neurodegenerative diseases
Neurodegeneration, known as the progressive loss of neurons in terms of their structure and function, is the principal pat...
Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia
Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia
This study examines the effectiveness of lupeol and metformin in a mouse model of dementia generated by intracerebroventri...
Transcriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats
Transcriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats
Subarachnoid hemorrhage (SAH) is a serious hemorrhagic event with high mortality and morbidity. Multiple injurious events ...
The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans
The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans
The aging of populations is a global phenomenon that follows a possible increase in the incidence of neurodegenerative dis...
Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia
Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia
The nature of brain redox metabolism in health, aging, and disease remains to be fully established. Reversible oxidations,...
The potential protective effect of Camellia Sinensis in mitigating monosodium glutamate-induced neurotoxicity: biochemical and histological study in male albino rats
The potential protective effect of Camellia Sinensis in mitigating monosodium glutamate-induced neurotoxicity: biochemical and histological study in male albino rats
Monosodium glutamate (MSG) is the sodium compound derived from glutamic acid. Excessive daily ingestion of MSG leads to el...
Rosuvastatin attenuates total-tau serum levels and increases expression of miR-124-3p in dyslipidemic Alzheimer's patients: a historic cohort study
Rosuvastatin attenuates total-tau serum levels and increases expression of miR-124-3p in dyslipidemic Alzheimer's patients: a historic cohort study
microRNAs are candidate diagnostic biomarkers for Alzheimer's disease. This study aimed to compare Silymarin with Rosu...
Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia
Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia
Oxidative stress from generation of increased reactive oxygen species or has been reported to play an important role in de...
Grape seed extract protects rat offspring hippocampus from the silicon dioxide nanoparticles’ neurotoxicity
Grape seed extract protects rat offspring hippocampus from the silicon dioxide nanoparticles’ neurotoxicity
Silicon dioxide nanoparticles (SiO2-NPs) can be found in many products, such as composites, paints, ceramics, consumer pro...
Exploring the active components and potential mechanisms of Alpiniae oxyphyllae Fructus in treating diabetes mellitus with depression by UPLC-Q-Exactive Orbitrap/MS, network pharmacology and molecular docking
Exploring the active components and potential mechanisms of Alpiniae oxyphyllae Fructus in treating diabetes mellitus with depression by UPLC-Q-Exactive Orbitrap/MS, network pharmacology and molecular docking
The growing incidence of diabetes mellitus (DM) and depression is a global public health issue. Alpiniae oxyphyllae Fructu...
New horizons for the role of selenium on cognitive function: advances and challenges
New horizons for the role of selenium on cognitive function: advances and challenges
Cognitive deficits associated with oxidative stress and the dysfunction of the central nervous system are present in some ...
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