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Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction
Ginsenoside CK modulates glucose metabolism via PPARγ to ameliorate SCOP-induced cognitive dysfunction
Ginsenoside compound K (CK) exhibits neuroprotective properties; however, the underlying mechanisms behind these effects h...
Alleviating effect of antioxidants on combined chromium and cadmium-induced neurotoxicity and apoptosis by activating the Nrf2-keap1 and associated pathway in albino mice
Alleviating effect of antioxidants on combined chromium and cadmium-induced neurotoxicity and apoptosis by activating the Nrf2-keap1 and associated pathway in albino mice
Chromium (Cr) and cadmium (Cd) are well-known cytotoxic and carcinogenic elements co-existing in the biosphere. Though the...
Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson’s disease
Exploring bioactive natural products for treating neurodegenerative diseases: a computational network medicine approach targeting the estrogen signaling pathway in amyotrophic lateral sclerosis and Parkinson’s disease
Amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) share overlapping molecular mechanisms, including e...
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling
Xifeng Jiannao Pill (XFJNP), a traditional Chinese medicine formulation, has been shown to alleviate clinical symptoms in ...
TCE-mediated neuroprotection against rotenone-induced dopaminergic neuronal death in PD mice: insights into the Nrf-2/PINK1/Parkin-mitophagy pathway
TCE-mediated neuroprotection against rotenone-induced dopaminergic neuronal death in PD mice: insights into the Nrf-2/PINK1/Parkin-mitophagy pathway
Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of Parkinson’s disease (PD). In...
Maternal-offspring brain and tissue cross-talk in preeclampsia: insights from a rat model
Maternal-offspring brain and tissue cross-talk in preeclampsia: insights from a rat model
This study aimed to investigate the differential metabolic profiles across maternal and offspring brains, serum, and place...
Potential therapeutic effects of curcumin, with or without L-DOPA, on motor and cognitive functions and hippocampal changes in rotenone-treated rats
Potential therapeutic effects of curcumin, with or without L-DOPA, on motor and cognitive functions and hippocampal changes in rotenone-treated rats
The neurodegenerative condition known as Parkinson’s disease (PD) is a long-term condition that causes both motor an...
Neuroprotective effects of ghrelin in cuprizone-induced rat model of multiple sclerosis
Neuroprotective effects of ghrelin in cuprizone-induced rat model of multiple sclerosis
Multiple sclerosis (MS) is an inflammatory central nervous system disease characterized by demyelination and axonal loss a...
Neuroprotective effects of Saxagliptin in traumatic brain injury: ameliorating oxidative stress, neuroinflammation, and apoptosis
Neuroprotective effects of Saxagliptin in traumatic brain injury: ameliorating oxidative stress, neuroinflammation, and apoptosis
Traumatic Brain Injury (TBI) is a significant global health issue characterized by disruptions in normal brain function du...
Gut microbiota and blood metabolites: unveiling their roles in hippocampal volume changes through Mendelian randomization and mediation analysis
Gut microbiota and blood metabolites: unveiling their roles in hippocampal volume changes through Mendelian randomization and mediation analysis
Changes in hippocampal volume (HV) are linked to various neuropsychiatric disorders. Observational studies suggest associa...
Disturbances in mitochondrial quality control and mitochondria-lysosome contact underlie the cerebral cortex and heart damage of mucopolysaccharidosis type II mice
Disturbances in mitochondrial quality control and mitochondria-lysosome contact underlie the cerebral cortex and heart damage of mucopolysaccharidosis type II mice
Mucopolysaccharidosis type II (or Hunter syndrome) is a lysosomal disease caused by mutations in the IDS gene, which encod...
Polysaccharides from attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation
Polysaccharides from attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation
Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganod...
ADAMTS18 deficiency leads to abnormal brain methylation metabolism, dysregulated neuroinflammatory response, and unsound blood-brain barrier structure in mice
ADAMTS18 deficiency leads to abnormal brain methylation metabolism, dysregulated neuroinflammatory response, and unsound blood-brain barrier structure in mice
ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family is a group of secretory proteases involved ...
Hepatic encephalopathy as an indication or contraindication to liver transplant?
Hepatic encephalopathy as an indication or contraindication to liver transplant?
Hepatic encephalopathy (HE) presents a significant challenge in liver transplantation (LT). On the one hand, LT can provid...
The role of Panax ginseng in neurodegenerative disorders: mechanisms, benefits, and future directions
The role of Panax ginseng in neurodegenerative disorders: mechanisms, benefits, and future directions
Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral scl...
Targeted metabolomics in children with autism spectrum disorder with and without developmental regression
Targeted metabolomics in children with autism spectrum disorder with and without developmental regression
Early diagnosis and intervention in children with autism spectrum disorder (ASD) is crucial. At present, diagnosis of ASD ...
Intermittent fasting reduces interictal epileptiform discharges and hippocampal reactive astrogliosis during electrical kindling epileptogenesis
Intermittent fasting reduces interictal epileptiform discharges and hippocampal reactive astrogliosis during electrical kindling epileptogenesis
It has been proposed that interictal epileptiform discharges observed in epilepsy-related structures, such as the hippocam...
L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo
L. enhance learning and cognitive function by modulating NMDA receptor and BDNF pathways in vitro and in vivo
Rumex acetosa L. (RA), a member of the Polygonaceae family, is called sorrel and has been used as a vegetable and traditio...
High urea promotes mitochondrial fission and functional impairments in astrocytes inducing anxiety-like behavior in chronic kidney disease mice
High urea promotes mitochondrial fission and functional impairments in astrocytes inducing anxiety-like behavior in chronic kidney disease mice
High urea can induce depression and anxiety. Activation of astrocytes is closely associated with psychiatric disorders. Ho...
Exercise-produced irisin effects on brain-related pathological conditions
Exercise-produced irisin effects on brain-related pathological conditions
Exercise increases peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) expression, which in...
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disorder with early autophagy deficits. Our study probed the role of l...
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Antidepressants remain the first-line treatment for depression. However, the factors influencing medication response are s...
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Depression is a mental disorder characterised by persistent low mood, anhedonia and cognitive impairment that affects an e...
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute liver failure or chronic liver injury. Liver dysfu...
Role of peripheral inflammation in minimal hepatic encephalopathy
Role of peripheral inflammation in minimal hepatic encephalopathy
Many patients with liver cirrhosis show minimal hepatic encephalopathy (MHE) with mild cognitive impairment (MCI) and moto...
Genomic, epigenomic and transcriptomic landscape of glioblastoma
Genomic, epigenomic and transcriptomic landscape of glioblastoma
The mostly aggressive and extremely malignant type of central nervous system is Glioblastoma (GBM), which is characterized...
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Neurological disorders are the primary cause of human disability and mortality globally, however, current medications slig...
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. The cleavage factor Im 25 (CFIm25)...
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Hepatic encephalopathy (HE) is a syndrome that is associated with both acute and chronic liver injury. It manifests as a w...
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Several recent studies have attempted to understand how fasting has benefits for body health, especially the nervous syste...
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