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Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus
Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type ses...
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China
Menthae Herba is an herbal medicine whose name is written with the same kanji characters (薄荷) in both the Ja...
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Azamollugin, a mollugin derivative, has inhibitory activity on MyD88- and TRIF-dependent pathways
Previously, we reported that azamollugin, an aza-derivative of mollugin, exhibited potent inhibitory activity on NO produc...
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit
Lysiphyllum binatum (Blanco) de Wit in the Fabaceae family, despite its traditional medicinal uses, has not been the subje...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for ...
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape ...
New sesquiterpenes from the soft coral Litophyton arboreum
New sesquiterpenes from the soft coral Litophyton arboreum
Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in...
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition...
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Acacia confusa Merr. (Fabaceae) (A. confusa) is a native tree species of Taiwan, commonly found in the low-altitude mounta...
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
Inflammation is a vital and normal physiological response; however, excessive inflammation can contribute to the ...
Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses
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Discovery of novel third generation P-glycoprotein inhibitors bearing an azo moiety with MDR-reversing effect
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Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria
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Identification of novel and potent triazoles targeting CYP51 for antifungal: Design, synthesis, and biological study
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First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease
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Discovery of sp3-rich diazatricycloundecanes as lysosomotropic autophagy inhibitors
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Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd–C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors
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Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics
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Adenanthin exhibits anti-inflammatory effects by covalently targeting the p65 subunit in the NF-κB signaling pathway
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Hit-to-lead optimization of 4,5-dihydrofuran-3-sulfonyl scaffold against Leishmania amazonensis. Effect of an aliphatic moiety
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Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis
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Identification of novel indolinone derivatives as CTSC inhibitors to treat inflammatory bowel disease by modulating inflammatory factors
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Design, synthesis, and bioactivity investigation of novel cyclic lipopeptide antibiotics targeting top-priority multidrug-resistant gram-negative bacteria
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Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives
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Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders
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