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Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Koningipyridines A and B, two nitrogen-containing polyketides from the fungus Trichoderma koningiopsis SC-5
Two novel koninginin derivatives, koningipyridines A and B (1 and 2), along with four known compounds (3˗6) were isol...
Precision enzyme discovery through targeted mining of metagenomic data
Precision enzyme discovery through targeted mining of metagenomic data
Metagenomics has opened new avenues for exploring the genetic potential of uncultured microorganisms, which may s...
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Neuroprotective properties of exosomes and chitosan nanoparticles of Tomafran, a bioengineered tomato enriched in crocins
Saffron has many pharmacological properties in addition to being a frequently used food seasoning. Crocin and picrocrocin ...
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity
As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction...
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient
Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natur...
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease
Marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake...
Natural and engineered xylosyl products from microbial source
Natural and engineered xylosyl products from microbial source
Glycosylation is a prevalent post-modification found in natural products and has a significant impact on the structural di...
Chemistry and biology of marine-derived Trichoderma metabolites
Chemistry and biology of marine-derived Trichoderma metabolites
Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with va...
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
Characterization of Chilean hot spring-origin Staphylococcus sp. BSP3 produced exopolysaccharide as biological additive
A type of high molecular weight bioactive polymers called exopolysaccharides (EPS) are produced by thermophiles, the extre...
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo
According to The World Alzheimer Report 2023 by Alzheimer’s Disease International (ADI) estimates that 33 to 38.5 mi...
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Libertellenone C attenuates oxidative stress and neuroinflammation with the capacity of NLRP3 inhibition
Neurodegenerative diseases (NDs) are common chronic diseases arising from progressive damage to the nervous system. Here, ...
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various ...
Current advances on the therapeutic potential of scutellarin: an updated review
Current advances on the therapeutic potential of scutellarin: an updated review
Scutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteracea...
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological p...
Which is the optimal choice for neonates’ formula or breast milk?
Which is the optimal choice for neonates’ formula or breast milk?
The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerab...
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Gastrodinol derivatives and prenylated flavones from the flower branch of Gastrodia elata
Based on the research progress and traditional usage with whole herbal of the TCM "Tianma", chemical studies her...
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two othe...
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Although non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalenc...
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz...
BioPrint meets the AI age: development of artificial intelligence-based ADMET models for the drug-discovery platform SAFIRE
BioPrint meets the AI age: development of artificial intelligence-based ADMET models for the drug-discovery platform SAFIRE
Background: To prioritize compounds with a higher likelihood of success, artificial intelligence models can be used to pre...
Chitosan–sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents
Chitosan–sulfonic acid-catalyzed green synthesis of naphthalene-based azines as potential anticancer agents
Aim: This study focuses on advancing green chemistry in anticancer drug discovery, particularly through the synthesis of a...
Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening
Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening
Background: DJ-1 is a ubiquitously expressed protein with multiple functions. Its overexpression has been associated with ...
Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies
Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies
Background: The scope of the study was to analyze original preclinical studies on the antimicrobial effects of carvacrol a...
Drug discovery and development: the role of artificial intelligence in drug repurposing
Drug discovery and development: the role of artificial intelligence in drug repurposing
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter o...
Design, synthesis and mechanistic study of new dual targeting HDAC/tubulin inhibitors
Design, synthesis and mechanistic study of new dual targeting HDAC/tubulin inhibitors
Aim: The purpose of this work is to create and synthesize a new class of chemicals: 3-cyano-2-substituted pyridine compoun...
Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors
Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors
Background: In Alzheimer’s disease, butyrylcholinesterase (BuChE) activity gradually increases, while acetylcholinesterase...
Exploring the antimicrobial and cytotoxic potential of novel chloroquine analogues
Exploring the antimicrobial and cytotoxic potential of novel chloroquine analogues
Aim: To synthesize novel chloroquine analogues and evaluate them for antimicrobial and cytotoxic potential. Methods: Novel...
Evaluation of novel synthesized thiazole derivatives as potential aromatase inhibitors against breast cancer
Evaluation of novel synthesized thiazole derivatives as potential aromatase inhibitors against breast cancer
Background: 4-Methylacetophenone is used in the preparation of starting materials, 4-methylphenacyle bromide (2) and 4-met...
Novel 1,2,4-triazoles as selective carbonic anhydrase inhibitors showing ancillary anticathepsin B activity
Novel 1,2,4-triazoles as selective carbonic anhydrase inhibitors showing ancillary anticathepsin B activity
Background: Exploration of the multi-target approach considering both human carbonic anhydrase (hCA) IX and XII and cathep...
The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs
The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs
This manuscript proposes an innovative approach to mitigate the gastrointestinal adversities linked with nonsteroidal anti...
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