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Integrative Metabolomics and Ionomics Identify Organ-Specific Responses Associated with Cisplatin Treatment in Mice
Integrative Metabolomics and Ionomics Identify Organ-Specific Responses Associated with Cisplatin Treatment in Mice
Integrative Metabolomics and Ionomics Identify Organ-Specific Responses Associated with Cisplatin Treatment in Mice
Comparison of Postoperative Analgesic Effects of Intravenous versus Perineural Dexamethasone Injection Combined with Ropivacaine in Thoracoscopy-Guided Thoracic Paravertebral Block for Thoracoscopic Radical Lung Cancer Resection: A Prospective Randomized Controlled Trial
Comparison of Postoperative Analgesic Effects of Intravenous versus Perineural Dexamethasone Injection Combined with Ropivacaine in Thoracoscopy-Guided Thoracic Paravertebral Block for Thoracoscopic Radical Lung Cancer Resection: A Prospective Randomized Controlled Trial
Evaluating postoperative analgesic effects of dexamethasone IV or perineurally with ropivacaine for TTPB in patients under...
Development of HPLC-MS/MS Method for Simultaneous Detection of Esketamine and Norketamine: Application to Pharmacokinetics Drug Interactions Affected by Dexmedetomidine
Development of HPLC-MS/MS Method for Simultaneous Detection of Esketamine and Norketamine: Application to Pharmacokinetics Drug Interactions Affected by Dexmedetomidine
A novel HPLC-MS/MS method was developed and validated, and successfully applied to simultaneously quantify ESK and NORK in...
A Narrative Review of Phase II and III Clinical Trials for the Pharmacological Treatment of Fibrodysplasia Ossificans Progressiva (FOP): Efficacy, Safety, and Challenges in Treatment Strategies
A Narrative Review of Phase II and III Clinical Trials for the Pharmacological Treatment of Fibrodysplasia Ossificans Progressiva (FOP): Efficacy, Safety, and Challenges in Treatment Strategies
Aims to provide a comprehensive overview of the therapeutic landscape, identify critical gaps in knowledge, and highlight ...
6-Hydroxygenistein Ameliorates High Altitude Brain Injury via Activating PI3K/AKT Signaling Pathway Based on Transcriptomic Analysis and Experimental Validation
6-Hydroxygenistein Ameliorates High Altitude Brain Injury via Activating PI3K/AKT Signaling Pathway Based on Transcriptomic Analysis and Experimental Validation
The objective of this study was to uncover the protective mechanism of 6-OHG against HHBI based on transcriptomics analysi...
Oxysophocarpine Inhibits Apoptosis of Lung Epithelial Cells to Alleviate Acute Lung Injury via KIT/PI3K Signaling Pathway
Oxysophocarpine Inhibits Apoptosis of Lung Epithelial Cells to Alleviate Acute Lung Injury via KIT/PI3K Signaling Pathway
to explore the protective efficacy of OSC against ALI and to thoroughly elucidate its underlying mechanisms.
Molecular Mechanism of Salvia Miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology [Corrigendum]
Molecular Mechanism of Salvia Miltiorrhiza in the Treatment of Colorectal Cancer Based on Network Pharmacology and Molecular Docking Technology [Corrigendum]
Corrigendum for the article Molecular Mechanism of Salvia miltiorrhiza in the Treatment of Colorectal Cancer Based on Netw...
Investigating the Mechanism of Jiawei Weijin Decoction in Treating Non-Small Cell Lung Cancer Using Network Pharmacology, Bioinformatics Analysis and Experimental Validation
Investigating the Mechanism of Jiawei Weijin Decoction in Treating Non-Small Cell Lung Cancer Using Network Pharmacology, Bioinformatics Analysis and Experimental Validation
The study on investigation and validation of JWWJD and its active components through network pharmacology, transcriptomics...
Safety of Remimazolam in Vulnerable Populations
Safety of Remimazolam in Vulnerable Populations
Analyzing the safety profile of Remimazolam in vulnerable populations, recovery outcomes, hemodynamic stability, and adver...
Development and Validation of an HPLC-MS/MS Method for Determining I-BET151 in Rat Plasma and Its application to Pharmacokinetic Studies
Development and Validation of an HPLC-MS/MS Method for Determining I-BET151 in Rat Plasma and Its application to Pharmacokinetic Studies
Establishing an HPLC-MS/MS method for determining the plasma concentration of I-BET151 and use it for pharmacokinetic stud...
Labor Analgesia Initiation with Dural Puncture Epidural versus Standard Epidural Techniques: A Prospective Randomized Dose Allocation Study of Ropivacaine
Labor Analgesia Initiation with Dural Puncture Epidural versus Standard Epidural Techniques: A Prospective Randomized Dose Allocation Study of Ropivacaine
There is no dose-sparing effect of ropivacaine when using the DPE technique vs. a standard epidural technique for labor an...
Pharmacokinetics, Relative Bioavailability, and Safety of the SHR0302 Oral Solution and Tablets: A Single-Center, Randomized, Open-Label, Crossover (Two-Formulation, Two-Period) Phase I Trial in Healthy Chinese Volunteers
Pharmacokinetics, Relative Bioavailability, and Safety of the SHR0302 Oral Solution and Tablets: A Single-Center, Randomized, Open-Label, Crossover (Two-Formulation, Two-Period) Phase I Trial in Healthy Chinese Volunteers
This study investigates the pharmacokinetic characteristics and relative bioavailability of SHR0302 oral solution & ta...
Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration
Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration
The review summarizes in vitro and in vivo biological effects of various biopolymers and active substances combined with p...
Huangqi Baihe Granules Attenuate Hypobaric Hypoxia-Induced Brain Injury via HIF-1a/p53/Caspase-3 Pathway
Huangqi Baihe Granules Attenuate Hypobaric Hypoxia-Induced Brain Injury via HIF-1a/p53/Caspase-3 Pathway
this study aims to investigate whether HQBHG participates in preventing and treating HACE by modulating the ‌HIF-1&al...
A Novel Letrozole Stair-Step Duration Regimen for Ovulation Induction in Women with Polycystic Ovary Syndrome and Letrozole Resistance
A Novel Letrozole Stair-Step Duration Regimen for Ovulation Induction in Women with Polycystic Ovary Syndrome and Letrozole Resistance
we conduct this retrospective study to evaluate whether the stair-step duration protocol is effective in inducing ovulatio...
Geniposide Stabilized Atherosclerosis Plaque by Induced M2 Polarization via PPARγ Signaling Pathway
Geniposide Stabilized Atherosclerosis Plaque by Induced M2 Polarization via PPARγ Signaling Pathway
In this study, we have further explored the molecular mechanism of the therapeutic effect of Gen on AS based on the origin...
Deciphering the Role of Oroxylin A in Liver Fibrosis
Deciphering the Role of Oroxylin A in Liver Fibrosis
This review comprehensively examines the natural flavonoid compound Oroxylin A (OA), which regulates hepatocyte senescence...
Emodin Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Directly Targeting TAK1
Emodin Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Directly Targeting TAK1
we employed network pharmacology approaches to identify potential targets of emodin in alleviating PAH and combined these ...
Estimation of ED50 and ED95 of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial
Estimation of ED50 and ED95 of Oliceridine Required to Suppress the Bronchoscopy Response in Patients Undergoing Fiberoptic Bronchoscopy Under Sedation with Cipepofol: An Up-and-Down Sequential Allocation Trial
Estimating median effective dose ED50 of oliceridine for suppressing bronchoscopy response during fiberoptic bronchoscopy ...
Combined Esketamine and Dexmedetomidine Decreases the Risk of Postoperative Delirium in Neurosurgical Pediatrics: A Randomized Controlled Trial
Combined Esketamine and Dexmedetomidine Decreases the Risk of Postoperative Delirium in Neurosurgical Pediatrics: A Randomized Controlled Trial
To investigate whether combined esketamine and dexmedetomidine could decrease the risk of postoperative delirium in neuros...
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
Inhibitory effects of corylin derived from aerial part of on melanin synthesis and potential applications in skin whitening and photoaging management
This study aimed to investigate the potential of corylin, a bioactive compound isolated from the aerial part of Pueraria l...
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Rational search for natural antimicrobial compounds: relevance of sesquiterpene lactones
Antimicrobial resistance is one of the most pressing global health challenges, as many pathogens are rapidly evolving to e...
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
New sesquiterpenoids with anti-inflammatory effects from phytopathogenic fungus 11134
Sesquiterpenoids represent a structurally diverse class of natural products widely recognized for their ecological signifi...
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by L. saponins: a new approach for the treatment of -induced bacterial keratitis
Pseudomonas aeruginosa-induced bacterial keratitis is one of the most sight-threatening corneal infections associated with...
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Maxim
In this work, six pairs of undescribed enantiomeric prenylated flavonoids, ( ±)-epimesatines J–O (1a/1b&#...
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Concise syntheses of natural diarylheptanoids containing a 1,4-pentadiene unit
Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids (1–3) cont...
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Enantiomeric diarylheptanoids from var. and their -glucosidase inhibitory activity
Otteacumienes G–K (1–5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptano...
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Polyprenylated acylphloroglucinols from species and structural revision of seven analogues
Our continuous study of the fruits of Garcinia xanthochymus and Garcinia subelliptica led to the isolation and structural ...
Chemical constituents of leaves and their anti-rheumatoid arthritis activity in vitro
Chemical constituents of leaves and their anti-rheumatoid arthritis activity in vitro
Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidate...
Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics inand
Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics inand
The use of natural products as antibiotic adjuvants to enhance efficacy and mitigate resistance is increasingly recognized...
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