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Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking
Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking
Resolving protein–protein interactions (PPIs) inside biomolecular condensates is crucial for elucidating their funct...
Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their macroscale transport
Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their macroscale transport
Fuelled chemical systems have considerable functional potential that remains largely unexplored. Here we report an approac...
Pore configuration control in hybrid azolate ultra-microporous frameworks for sieving propylene from propane
Pore configuration control in hybrid azolate ultra-microporous frameworks for sieving propylene from propane
Developing porous adsorbents for the complete sieving of propylene/propane mixtures represents an alternative method to en...
Catalysis-enabled amine sorting
Catalysis-enabled amine sorting
Multicomponent couplings offer powerful approaches for rapidly increasing molecular complexity, but typically require func...
Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines
Dynamic amine sorting enables multiselective construction of unsymmetrical chiral diamines
Precisely differentiating chemicals featuring minor discrepancies is the prerequisite for achieving high selectivities in ...
Isolation and characterization of a triplet nitrene
Isolation and characterization of a triplet nitrene
Nitrene radical compounds are short-lived intermediates in a variety of nitrogen-involved transformations. They feature ei...
Cyclic amine ring expansion
Cyclic amine ring expansion
Aza-heterocycles with rings of more than 6 members are underrepresented in medicinal chemistry owing to challenges with th...
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion
Saturated N-heterocycles are ubiquitous structures among natural products and biologically active compounds. Therefore, th...
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon
The relationship between the shape of a molecule and its chemical reactivity is a central tenet in chemistry. However, the...
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell sig...
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway
While natural terpenoid cyclases generate complex terpenoid structures via cationic mechanisms, alternative radical cycliz...
A template for artificial life
A template for artificial life
Selection rules play an important role in Darwinian evolution. Now, it has been shown that selective templation enables th...
Phosphorus-mediated hydrogenation catalysis
Phosphorus-mediated hydrogenation catalysis
Hydrogenation catalysis is commonly associated with (noble) transition metals that undergo oxidative addition of H2 and su...
Light strikes gold to purify water
Light strikes gold to purify water
Hydroxyl radicals (·OH) are important reactive oxygen species in environmental chemistry. The most efficient way to g...
Copper catalysed asymmetric amination
Copper catalysed asymmetric amination
Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are chal...
Blocking and rescuing tryptophan interactions
Blocking and rescuing tryptophan interactions
Expansion of the genetic code can enable precise manipulation of proteins through selective functionalization of specific ...
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000–1,700 nm) and extended SWIR (ESWIR, 1,700&...
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Hydrogen evolution is an important fuel-generating reaction that has been subject to mechanistic debate about the roles of...
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine undergoes a range of acylations, i...
Lifting iron higher and higher
Lifting iron higher and higher
Biological and synthetic catalysts often utilize iron in high oxidation states (+IV and greater) to perform challenging mo...
Bridging the information gap in organic chemical reactions
Bridging the information gap in organic chemical reactions
The varying quality of scientific reports is a well-recognized problem and often results from a lack of standardization an...
Expanding the molecular language of protein liquid–liquid phase separation
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation has important implications for anal...
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive ...
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at the α-carbon centr...
Organocatalytic aromatization-promoted umpolung reaction of imines
Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared...
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cells are biomimetic microstructures that mimic functions of natural cells, can be applied as building blocks f...
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashio...
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Substitution of a C=C bond by an isoelectronic B–N bond is a well-established strategy to alter the electronic struc...
Azobenzene as a photoswitchable mechanophore
Azobenzene as a photoswitchable mechanophore
Azobenzene has been widely explored as a photoresponsive element in materials science. Although some studies have investig...
Cooperative H2 activation at a nickel(0)–olefin centre
Cooperative H2 activation at a nickel(0)–olefin centre
Catalytic olefin hydrogenation is ubiquitous in organic synthesis. In most proposed homogeneous catalytic cycles, reactive...
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