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Copper catalysed asymmetric amination
Copper catalysed asymmetric amination
Chiral amines possessing a stereogenic carbon atom bearing three carbon substituents and one nitrogen substituent are chal...
Blocking and rescuing tryptophan interactions
Blocking and rescuing tryptophan interactions
Expansion of the genetic code can enable precise manipulation of proteins through selective functionalization of specific ...
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000–1,700 nm) and extended SWIR (ESWIR, 1,700&...
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Catalyst self-assembly accelerates bimetallic light-driven electrocatalytic H2 evolution in water
Hydrogen evolution is an important fuel-generating reaction that has been subject to mechanistic debate about the roles of...
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine undergoes a range of acylations, i...
Lifting iron higher and higher
Lifting iron higher and higher
Biological and synthetic catalysts often utilize iron in high oxidation states (+IV and greater) to perform challenging mo...
Bridging the information gap in organic chemical reactions
Bridging the information gap in organic chemical reactions
The varying quality of scientific reports is a well-recognized problem and often results from a lack of standardization an...
Expanding the molecular language of protein liquid–liquid phase separation
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation has important implications for anal...
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive ...
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at the α-carbon centr...
Organocatalytic aromatization-promoted umpolung reaction of imines
Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared...
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cells are biomimetic microstructures that mimic functions of natural cells, can be applied as building blocks f...
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashio...
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Substitution of a C=C bond by an isoelectronic B–N bond is a well-established strategy to alter the electronic struc...
Azobenzene as a photoswitchable mechanophore
Azobenzene as a photoswitchable mechanophore
Azobenzene has been widely explored as a photoresponsive element in materials science. Although some studies have investig...
Cooperative H2 activation at a nickel(0)–olefin centre
Cooperative H2 activation at a nickel(0)–olefin centre
Catalytic olefin hydrogenation is ubiquitous in organic synthesis. In most proposed homogeneous catalytic cycles, reactive...
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
Although α-chiral C(sp3)–S bonds are of enormous importance in organic synthesis and related areas, the transit...
The year dot
The year dot
Quantum dots are nanometre-sized semiconducting crystals. While chemists tend to interrogate molecular structure to unders...
From feedstock to pharmaceuticals
From feedstock to pharmaceuticals
Fluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecu...
An acid for an acid
An acid for an acid
Stereoselective decarboxylative protonation can produce diverse chiral molecules from widely available carboxylic acids. H...
The joys and challenges of teaching for the first time
The joys and challenges of teaching for the first time
Becoming an assistant professor brings with it numerous challenges, one of which is teaching undergraduate courses for the...
Insulin investigations
Insulin investigations
Daniel Rabinovich outlines the story of insulin, the essential drug for the treatment of diabetes during the past century.
Lateral epitaxial growth of two-dimensional organic heterostructures
Lateral epitaxial growth of two-dimensional organic heterostructures
Two-dimensional organic lateral heterostructures (2D OLHs) are attractive for the fabrication of functional materials. How...
Using symmetry to drive new protein assemblies
Using symmetry to drive new protein assemblies
Recent improvements in de novo protein design are likely to support a broad range of applications, but larger complexes wi...
Author Correction: Circumventing the stability problems of graphene nanoribbon zigzag edges
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Publisher Correction: Photocatalytic hydrofluoroalkylation of alkenes with carboxylic acids
Author notesThese authors contributed equally: Kang-Jie Bian, Yen-Chu Lu.Authors and AffiliationsDepartment of Chemistry, ...
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
Late-stage functionalization is an economical approach to optimize the properties of drug candidates. However, the chemica...
A general strategy to develop fluorogenic polymethine dyes for bioimaging
A general strategy to develop fluorogenic polymethine dyes for bioimaging
Fluorescence imaging is an invaluable tool to study biological processes and further progress depends on the development o...
Publisher Correction: Droplet slipperiness despite surface heterogeneity at molecular scale
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Phase-separation behaviour of RNAs
Phase-separation behaviour of RNAs
Ribonucleoprotein granules are ubiquitous in living organisms with the protein and RNA components having distinct roles. I...
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