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Long-term outcomes of sentinel lymph node navigation surgery for early-stage cervical cancer
Long-term outcomes of sentinel lymph node navigation surgery for early-stage cervical cancer
Sentinel lymph node navigation surgery, which identifies the sentinel lymph node in early cervical cancers and omits syste...
Clinical outcomes of first-line combination therapy with immune checkpoint inhibitor for metastatic non-clear cell renal cell carcinoma: a multi-institutional retrospective study in Japan
Clinical outcomes of first-line combination therapy with immune checkpoint inhibitor for metastatic non-clear cell renal cell carcinoma: a multi-institutional retrospective study in Japan
In metastatic clear cell renal cell carcinoma (ccRCC), recent studies have shown promising efficacy of immune checkpoint i...
Current status of BAFF targeting immunotherapy in B-cell neoplasm
Current status of BAFF targeting immunotherapy in B-cell neoplasm
B-cell activating factor belonging to the TNF family (BAFF), also known as B-lymphocyte stimulator (BLyS), plays a crucial...
Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey
Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey
The expenses related to fertility preservation or subsequent assisted reproductive treatments are significant for adolesce...
Maediastinal germ cell tumors: analysis using hospital-based cancer registry data in Japan
Maediastinal germ cell tumors: analysis using hospital-based cancer registry data in Japan
Mediastinal germ cell tumors are rare and few large-scale studies on mediastinal germ cell tumors are reported. We aimed t...
Local extension findings on MRI compensate for the ability of pathological staging to predict oncological outcome
Local extension findings on MRI compensate for the ability of pathological staging to predict oncological outcome
We investigated whether local extension findings on preoperative MRI and excisional pathology are associated with positive...
Genomic landscape of cutaneous, acral, mucosal, and uveal melanoma in Japan: analysis of clinical comprehensive genomic profiling data
Genomic landscape of cutaneous, acral, mucosal, and uveal melanoma in Japan: analysis of clinical comprehensive genomic profiling data
Cutaneous melanoma (CM) is the most common type in Caucasians, while acral melanoma (AM) and mucosal melanoma (MM), which ...
Defining the clinical benefits of adding a neurokinin-1 receptor antagonist to control chemotherapy-induced nausea and vomiting in moderately emetogenic chemotherapy: a systematic review and meta-analysis of the clinical practice guidelines for antiemesis 2023 from the Japan society of clinical oncology
Defining the clinical benefits of adding a neurokinin-1 receptor antagonist to control chemotherapy-induced nausea and vomiting in moderately emetogenic chemotherapy: a systematic review and meta-analysis of the clinical practice guidelines for antiemesis 2023 from the Japan society of clinical oncology
Chemotherapy-induced nausea and vomiting (CINV) commonly affects patient quality of life and the overall effectiveness of ...
Efficacy and safety of adjuvant nivolumab after radical surgery for high-risk urothelial carcinoma: a preliminary report of real-world data from a single institution
Efficacy and safety of adjuvant nivolumab after radical surgery for high-risk urothelial carcinoma: a preliminary report of real-world data from a single institution
The phase 3 CheckMate 274 trial demonstrated superiority of adjuvant nivolumab over placebo after radical surgery in patie...
Clinical impact of concomitant BIO-three use in advanced or recurrent non-small cell lung cancer treated with immune-checkpoint inhibitor
Clinical impact of concomitant BIO-three use in advanced or recurrent non-small cell lung cancer treated with immune-checkpoint inhibitor
Immune checkpoint inhibitors (ICIs) have been approved as first-line therapy for advanced non-small cell lung cancer (NSCL...
Neutrophil-to-lymphocyte ratio at the end of treatment with CDK4/6 inhibitors is an independent prognostic factor for ER-positive HER2-negative advanced breast cancer
Neutrophil-to-lymphocyte ratio at the end of treatment with CDK4/6 inhibitors is an independent prognostic factor for ER-positive HER2-negative advanced breast cancer
The aim of this study was to elucidate the clinical significance of peripheral blood biomarkers, including absolute lympho...
Molecular profiling of risk factors for relapse in Japanese patients with stage II colorectal cancer: a retrospective cohort study
Molecular profiling of risk factors for relapse in Japanese patients with stage II colorectal cancer: a retrospective cohort study
The association between the molecular profiles and prognosis of Stage II colorectal cancer remains unclear. This study aim...
A machine learning-based method for feature reduction of methylation data for the classification of cancer tissue origin
A machine learning-based method for feature reduction of methylation data for the classification of cancer tissue origin
Genome DNA methylation profiling is a promising yet costly method for cancer classification, involving substantial data. W...
Pembrolizumab in Japanese patients with primary mediastinal large B-cell lymphoma: results from the KEYNOTE-A33 study
Pembrolizumab in Japanese patients with primary mediastinal large B-cell lymphoma: results from the KEYNOTE-A33 study
KEYNOTE-A33 (NCT04317066) is an open-label, single-arm, phase 1 trial designed to evaluate the safety and efficacy of pemb...
Current status and prospects of breast cancer imaging-based diagnosis using artificial intelligence
Current status and prospects of breast cancer imaging-based diagnosis using artificial intelligence
Breast imaging has several modalities, each unique in terms of its imaging position, evaluation index, and imaging method....
Clinical utility of a comprehensive genomic profiling test for patient with advanced biliary tract cancer
Clinical utility of a comprehensive genomic profiling test for patient with advanced biliary tract cancer
Biliary tract cancer (BTC) comprises a heterogeneous group of malignancies with poor prognosis because of the limited trea...
Preliminary results from ASCENT-J02: a phase 1/2 study of sacituzumab govitecan in Japanese patients with advanced solid tumors
Preliminary results from ASCENT-J02: a phase 1/2 study of sacituzumab govitecan in Japanese patients with advanced solid tumors
Sacituzumab govitecan (SG) is a Trop-2–directed antibody–drug conjugate approved outside Japan for second-line...
Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab
Exploratory analysis of serum HER2 extracellular domain for HER2 positive gastric cancer treated with SOX plus trastuzumab
The aim of this study was to explore the clinical utility of serum HER2 extracellular domain (sHER2 ECD) using data from a...
Salivary gland-type cancers: cross-organ demographics of a rare cancer
Salivary gland-type cancers: cross-organ demographics of a rare cancer
Salivary gland-type cancers (SGTCs) are histologically heterogeneous and can affect organs other than the salivary glands....
English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
English version of Japanese Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) issued by the Japan Society of Clinical Oncology
The Japan Society of Clinical Oncology Clinical Practice Guidelines 2022 for gastrointestinal stromal tumor (GIST) have be...
Local excision versus radical surgery for anal squamous cell carcinoma: a multicenter study in Japan
Local excision versus radical surgery for anal squamous cell carcinoma: a multicenter study in Japan
The standard treatment for anal squamous cell carcinoma is chemoradiation therapy (CRT), but there is a possibility of ove...
PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site
PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site
Cancer of unknown primary site (CUP) is a heterogeneous group of tumors for which the origin remains unknown. Clinical out...
Favorable clinical efficacy of cytotoxic chemotherapy in patients with progressive desmoid tumors: a retrospective real-world study
Favorable clinical efficacy of cytotoxic chemotherapy in patients with progressive desmoid tumors: a retrospective real-world study
The real-world evidence about the efficacy of cytotoxic chemotherapy in desmoid tumors is still limited. We investigated t...
Therapeutic use of granulocyte colony-stimulating factor (G-CSF) in patients with febrile neutropenia: a comprehensive systematic review for clinical practice guidelines for the use of G-CSF 2022 from the Japan Society of Clinical Oncology
Therapeutic use of granulocyte colony-stimulating factor (G-CSF) in patients with febrile neutropenia: a comprehensive systematic review for clinical practice guidelines for the use of G-CSF 2022 from the Japan Society of Clinical Oncology
Febrile neutropenia represents a critical oncologic emergency, and its management is pivotal in cancer therapy. In several...
A real-world study of treatment sequences and second-line clinical outcomes in patients with HER2-positive metastatic breast cancer in US community practice
A real-world study of treatment sequences and second-line clinical outcomes in patients with HER2-positive metastatic breast cancer in US community practice
Standard-of-care for HER2-positive metastatic breast cancer (HER2 + mBC) patients consists of trastuzumab̴...
Impact of disease volume on survival efficacy of triplet therapy for metastatic hormone-sensitive prostate cancer: a systematic review, meta-analysis, and network meta-analysis
Impact of disease volume on survival efficacy of triplet therapy for metastatic hormone-sensitive prostate cancer: a systematic review, meta-analysis, and network meta-analysis
Triplet therapy, androgen receptor signaling inhibitors (ARSIs) plus docetaxel plus androgen-deprivation therapy (ADT), is...
Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
Granulocyte colony-stimulating factor (G-CSF) is widely used for the primary prophylaxis of febrile neutropenia (FN). Two ...
SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy
SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy
Photoimmunotherapy is a treatment modality that induces targeted cell death by binding a molecular-targeted drug activated...
Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery
Early experience and future prospects regarding use of newly developed surgical robot system, hinotori, in the field of urologic cancer surgery
In the field of urology, robotic surgery has gained rapid and wide acceptance as a standard surgical approach in the major...
MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
Few studies have reported reliable prognostic factors for immune checkpoint inhibitors (ICIs) in renal cell carcinoma (RCC...
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