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Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis
Alzheimer disease (AD) is the most common form of dementia affecting more than 6 million people in the United States. Curr...
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Immunohistochemical evaluation of a trial of gantenerumab or solanezumab in dominantly inherited Alzheimer disease
Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement f...
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Multifactorial etiology of progressive supranuclear palsy (PSP): the genetic component
Progressive supranuclear palsy (PSP) is mainly a sporadic disease. It has a multifactorial etiology and an interaction bet...
Outcome-associated factors in a molecularly defined cohort of central neurocytoma
Outcome-associated factors in a molecularly defined cohort of central neurocytoma
Central neurocytomas (CN) are intraventricular brain tumors predominantly occurring in young adults. Although prognosis is...
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
Characterization of prion strains and peripheral prion infectivity patterns in E200K genetic CJD patients
The mutation E200K in the prion protein gene (PRNP) is the most common variant in genetic Creutzfeldt–Jakob disease ...
Role of CSF flow and meningeal barriers in the development of inflammatory lesions at the CNS–PNS transition zone of cranial nerves in autoimmune demyelinating diseases
Role of CSF flow and meningeal barriers in the development of inflammatory lesions at the CNS–PNS transition zone of cranial nerves in autoimmune demyelinating diseases
Patients with autoimmune inflammatory demyelinating diseases have been shown to present with trigeminal and cochlear nerve...
The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system
The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system
Olfactory impairment is a recognized early indicator of neurodegenerative diseases (NDs), such as Alzheimer’s diseas...
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice
Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice
Our recent work on the prion protein and Na+, K+-ATPases (NKAs) led us to revisit data from over 50 years ago, wh...
CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma
CNS methylation classifiers may misclassify normal developing cerebellar cortex as medulloblastoma
Methylation profiling for tumor classification has entered mainstream neuropathology ...
Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants
Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants
The identification of biomarkers predicting the burden of brain alpha-synuclein (α-syn) pathology in vivo represents ...
Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature
Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Subclinical detection of misfolded alpha-synuclein in the blood of M83 mice
Subclinical detection of misfolded alpha-synuclein in the blood of M83 mice
Barbour R, Kling K, Anderson JP, Banducci K, Cole T, Diep L et al (2008) Red blood cells are the major source of alpha-syn...
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder marked by amyloid-β (Aβ) deposition in blood ves...
Primary papillary epithelial tumor of the sella harboring an Y646F mutation
Primary papillary epithelial tumor of the sella harboring an Y646F mutation
Sellar and suprasellar tumors encompass a heterogeneous array of neoplasms, including...
Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease
Amyloid-β plaque-associated microglia drive TSPO upregulation in Alzheimer’s disease
Translocator protein 18 kDA (TSPO) imaging using positron emission tomography (PET) is widely used to assess neuroinflamma...
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits
ATP10B, a transmembrane lipid flippase located in late endosomes and lysosomes, facilitates the export of glucosylceramide...
Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum
Isomerized Aβ in the brain can distinguish the status of amyloidosis in the Alzheimer’s disease spectrum
Extracellular amyloid plaques, the pathognomonic hallmark of Alzheimer’s disease (AD), are also observed in cognitiv...
Sensitivity of associative priming to semantic relations: Insights from behavior and event-related potentials
As we all know, previous mental processing can influence our subsequent behaviors, such as priming. This factor has garner...
DREADD-mediated inhibition of anterior retrosplenial cortex: Effects on novelty recognition of objects, locations, and object-in-place associations in male and female Long Evans rats
The data that support the findings of this study are available from the corresponding author upon reasonable request. The ...
Synergistic impact of early-life stress and prenatal immune activation on spatial memory and oxidative metabolism in rat cortico-limbic networks
Early life exposure to immune activation and stress are critical factors involved in the development of mental and neurode...
Delayed emergence of EEG-based task-relevant representations
Recent experiments in humans have shown that a period of Quiet Wakefulness, also known as “Quiescence” or “Offline Wake St...
Developmental changes in brain-wide fear memory networks
Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks ...
Engrams across diseases: Different pathologies – unifying mechanisms?
Memories are our reservoir of knowledge and thus, are crucial for guiding decisions and defining our self. The physical co...
Engram and behavior: How memory is stored in the brain
How memories are processed and where they are stored have long been the subject of scholarly inquiry. In ancient times, th...
The molecular and cellular basis of memory engrams: Mechanisms of synaptic and systems consolidation
Memory can be defined as representations of daily experiences that are stored for hours, months, years or even a lifetime....
Assessing the role of BNST GABA neurons in backward conditioned suppression
Conditioned suppression is a psychology-based task to understand how learned cues interrupt ongoing reward-seeking behavio...
Investigations of forgetting in Caenorhabditis elegans
The traditional view considered forgetting as a passive process where memory traces gradually fade due to the natural weak...
Memory processing by hippocampal adult-born neurons
This review provides an integrative overview of the functional roles of adult neurogenesis in the hippocampal dentate gyru...
Female rats retain goal-directed planning of action sequences after acute stress despite changes in planning structure and action sequence execution
In predictable environments organisms often use habitual forms of behavior as a means to conserve cognitive resources (Bou...
Hormonal regulation of behavioral and emotional persistence: Novel insights from a systems-level approach to neuroendocrinology
While hormones have long been associated with powerful changes in mood, internal state, and behavior, recent work has begu...
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