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PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Intrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenot...
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
This study was designed to investigate the role and mechanism of cancer-associated fibroblasts (CAFs)-derived exosomes (CA...
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in ...
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show...
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 is a member of the tumor necrosis factor receptor superfamily, and its function exhibits variability among differ...
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitum...
Novel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology
Novel biomarker SARIFA in colorectal cancer: highly prognostic, not genetically driven and histologic indicator of a distinct tumor biology
SARIFA (Stroma AReactive Invasion Front Areas) has recently emerged as a promising histopathological biomarker for colon a...
METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway
METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway
Liver cancer stem cells (LCSCs) contribute to tumor recurrence and cancer cell proliferation in patients with hepatocellul...
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR
CASC4/GOLM2 drives high grade serous carcinoma anoikis resistance through the recycling of EGFR
Ovarian cancer is the deadliest gynecological malignancy, and accounts for over 150,000 deaths per year worldwide. The hig...
Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1
Arvanil induces ferroptosis of hepatocellular carcinoma by binding to MICU1
Hepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate that requires research and improved tr...
IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma
IGH repertoire analysis at scale: deciphering the complexity of B cell infiltration and migration in esophageal squamous cell carcinoma
Tumor-infiltrating B-lineage cells have become predictors of prognosis and immunotherapy responses in various cancers. How...
Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
Downstream STING pathways IRF3 and NF-κB differentially regulate CCL22 in response to cytosolic dsDNA
Double-stranded DNA (dsDNA) in the cytoplasm of eukaryotic cells is abnormal and typically indicates the presence of patho...
Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells
Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8+ T-cell immunity towards cancer cells
Antibody-mediated delivery of immunogenic epitopes to redirect virus-specific CD8+ T-cells towards cancer cells is an emer...
Identification of circATG9A as a novel biomarker for renal cell carcinoma
Identification of circATG9A as a novel biomarker for renal cell carcinoma
The incidence and mortality rates of renal cell carcinoma (RCC) have rapidly increased worldwide. To gain new insights int...
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts
MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts
The replication-stress response is essential to ensure the faithful transmission of genetic information to daughter cells....
Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Despite good results in the treatment of hematological malignancies, Natural killer (NK) cells have shown limited effectiv...
Correction: The KRAS-G12C inhibitor: activity and resistance
Authors and AffiliationsThe Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, ChinaJiao Liu...
STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines
STK11 loss leads to YAP1-mediated transcriptional activation in human KRAS-driven lung adenocarcinoma cell lines
Serine Threonine Kinase 11 (STK11) loss of function (LoF) correlates with anti-PD-1 therapy resistance in patients with KR...
CILP is a potential pan-cancer marker: combined silico study and in vitro analyses
CILP is a potential pan-cancer marker: combined silico study and in vitro analyses
CILP (Cartilage intermediate layer protein), an ECM (extracellular matrix) glycoprotein, is found to be associated with in...
Research progress and application of single-cell sequencing in head and neck malignant tumors
Research progress and application of single-cell sequencing in head and neck malignant tumors
Single-cell sequencing (SCS) is a technology that separates thousands of cells from the organism and accurately analyzes t...
Exploration of a screening model for intrahepatic cholangiocarcinoma patients prone to cuproptosis and mechanisms of the susceptibility of CD274-knockdown intrahepatic cholangiocarcinoma cells to cuproptosis
Exploration of a screening model for intrahepatic cholangiocarcinoma patients prone to cuproptosis and mechanisms of the susceptibility of CD274-knockdown intrahepatic cholangiocarcinoma cells to cuproptosis
Intrahepatic cholangiocarcinoma (ICC) is a form of liver cancer with poor long-term survival rates that requires novel the...
The effects of intracellular and exosomal ncRNAs on cancer progression
The effects of intracellular and exosomal ncRNAs on cancer progression
Altered gene expression as well as mislocalization of a gene’s encoded product (proteins or noncoding RNAs (ncRNAs))...
LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression
LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression
Non-small cell lung cancer (NSCLC) is a common and lethal malignancy. The carcinogenic roles of lncRNA CALML3 antisense RN...
LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10
LAMC2 mitigates ER stress by enhancing ER-mitochondria interaction via binding to MYH9 and MYH10
Highly proliferative and metastatic tumors are constantly exposed to both intrinsic and extrinsic factors that induce adap...
Retraction Note: Overexpressed transient receptor potential vanilloid 1 (TRPV1) in lung adenocarcinoma harbours a new opportunity for therapeutic targeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Correction to: Downregulation of miR-221/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3
Correction to: Downregulation of miR-221/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3
Authors and AffiliationsWenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, ChinaR. Gan, ...
Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis
Anti-leukemia effects of omipalisib in acute myeloid leukemia: inhibition of PI3K/AKT/mTOR signaling and suppression of mitochondrial biogenesis
Omipalisib (GSK2126458), a potent dual PI3K/mTOR inhibitor, is reported to exhibit anti-tumor effect in several kinds of c...
Retraction Note: Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer
These authors contributed equally: Donge Tang, Jiaxi He, Yong DaiResearch Center of Medical Sciences, Guangdong Provincial...
Correction: α-Catenin acetylation is essential for its stability and blocks its tumor suppressor effects in breast cancer through Yap1
In this article, the ‘Contributions’ statement was incorrectly given as ‘Conceptualization, WH, and RP; methodology, YY, a...
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