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Airway disease decreases the therapeutic potential of epithelial stem cells
Airway disease decreases the therapeutic potential of epithelial stem cells
Tissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However,...
Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Hemoadsorption in acute respiratory distress syndrome patients requiring venovenous extracorporeal membrane oxygenation: a systematic review
Venovenous extracorporeal membrane oxygenation (VV ECMO) has been widely used for severe acute respiratory distress syndro...
Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically ill patients, characterized by...
Microbes little helpers and suppliers for therapeutic asthma approaches
Microbes little helpers and suppliers for therapeutic asthma approaches
Bronchial asthma is a prevalent and increasingly chronic inflammatory lung disease affecting over 300 million people globa...
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases
Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem i...
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in develop...
Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation
Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation
Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates....
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whethe...
Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various...
PTK2-associated gene signature could predict the prognosis of IPF
PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clini...
Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein–protein interaction analyses
Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein–protein interaction analyses
Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biol...
Prediction of the number of asthma patients using environmental factors based on deep learning algorithms
Prediction of the number of asthma patients using environmental factors based on deep learning algorithms
Air pollution, weather, pollen, and influenza are typical aggravating factors for asthma. Previous studies have identified...
CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
It is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease...
In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remod...
METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway
METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway
The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of...
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires bo...
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
People living with chronic obstructive pulmonary disease (COPD) have an increased risk of experiencing cardiovascular (CV)...
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermo...
Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammator...
Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung disease, is a leading cause of morbidity and mor...
Animal models of acute exacerbation of pulmonary fibrosis
Animal models of acute exacerbation of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. So...
Impact of sex differences on cardiac injury in critically ill patients with COVID-19
Impact of sex differences on cardiac injury in critically ill patients with COVID-19
COVID-19 infections are associated with accrued inflammatory responses which may result in cardiac injury. Immune response...
The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study
The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study
Several observational studies have found that physical inactivity and sedentary time are associated with idiopathic pulmon...
Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodel...
Clinical nomogram assisting in discrimination of juvenile dermatomyositis-associated interstitial lung disease
Clinical nomogram assisting in discrimination of juvenile dermatomyositis-associated interstitial lung disease
To establish a prediction model using non-invasive clinical features for early discrimination of DM-ILD in clinical practi...
Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study
Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study
FOOTPRINTS® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation...
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice
We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung dama...
Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-app...
Metagenomics for the microbiological diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia (HAP/VAP) in intensive care unit (ICU): a proof-of-concept study
Metagenomics for the microbiological diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia (HAP/VAP) in intensive care unit (ICU): a proof-of-concept study
Hospital-acquired and ventilator-associated-pneumonia (HAP/VAP) are one of the most prevalent health-care associated infec...
Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
Bronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsup...
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