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MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx)...
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely...
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diag...
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underly...
Epigenetics of the far northern Yakutian population
Epigenetics of the far northern Yakutian population
Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a contine...
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. T...
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecu...
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treat...
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natu...
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. ...
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has bee...
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive cl...
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of...
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and deve...
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary...
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery i...
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methyl...
N6-methyladenosine methylation in kidney injury
N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and ...
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progressio...
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impa...
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80–...
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may a...
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, e...
An epigenetic hypothesis for ovarian cancer prevention by oral contraceptive pill use
An epigenetic hypothesis for ovarian cancer prevention by oral contraceptive pill use
Ovarian cancer is the second most common gynecological cancer type after uterine cancers. In 2020, according to worldwide ...
Accelerated DNA methylation age plays a role in the impact of cardiovascular risk factors on the human heart
Accelerated DNA methylation age plays a role in the impact of cardiovascular risk factors on the human heart
DNA methylation (DNAm) age acceleration (AgeAccel) and cardiac age by 12-lead advanced electrocardiography (A-ECG) are pro...
Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
Previous studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as th...
Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers
Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers
Cigarette smoking and aging are the main risk factors for pulmonary diseases, including cancer. Epigenetic aging may expla...
A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism
A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism
MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-car...
Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study
Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study
Epigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-relate...
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